Rivaroxaban: Management of Coronary Artery Thrombosis in a Patient Presenting with Anterior Wall Myocardial Infarction

Rivaroxaban: Management of Coronary Artery Thrombosis

Authors

  • Ayesha Tariq King Edward Medical University/ Mayo Hospital, Lahore, Pakistan
  • Bilqees Akhtar King Edward Medical University/ Mayo Hospital, Lahore, Pakistan
  • Asma Sharif King Edward Medical University/ Mayo Hospital, Lahore, Pakistan

DOI:

https://doi.org/10.54393/pbmj.v6i08.927

Keywords:

Artery Thrombosis, Rivaroxaban, Anterior Wall Myocardial Infarction

Abstract

Coronary artery thrombosis is one of the most common clinically manifested disease that if not treated timely leads to morbidity and mortality particularly stroke or myocardial infarction. Anti-platelets are already the first line of treatment that are adopted for the prevention of coronary artery thrombosis however, there is need of a novel and potent anticoagulant that could help to reduce the frequency of coronary or atherothrombotic events in patients presenting with coronary diseases. Case Summary: We present a case of anterior wall myocardial infarction (AWMI) driven by coronary artery thrombosis. The patient upon diagnosis was found to have a clot in proximal left anterior descending artery (LAD). The patient was treated and discharged on anticoagulation therapy. We examined and report the effectiveness of anticoagulation therapy via a novel oral anticoagulant. i.e. Rivaroxaban for managing the risk of coronary artery thrombosis associated with AWMI within our patient. Onset of coronary artery thrombosis is associated with the mortality in myocardial infarct patients, regardless of its timing. This calls out for the need to manage the disease by adopting strategies that would prevent the frequent onset of these events in myocardial infarction survivors. Treatment with Rivaroxaban has emerged as a promising oral anticoagulant that could potentially serve as a long-term anticoagulant for managing coronary artery thrombosis in patients with heart complications.

References

Thygesen K, Alpert JS, Jaffe AS, Chaitman BR, Bax JJ, Morrow DA, et al. Executive group on behalf of the joint European society of cardiology (ESC)/American college of cardiology (ACC)/American heart association (AHA)/World heart federation (WHF) task force for the universal definition of myocardial infarction. Fourth universal definition of myocardial infarction (2018). Circulation. 2018 Nov; 138(20): e618-51. doi: 10.1161/CIR.0000000000000617. DOI: https://doi.org/10.1161/CIR.0000000000000617

Pamukcu B. Introductory Chapter: Atherosclerotic Cardiovascular. Myocardial Infarction. IntechOpen, 2018. doi: 10.5772/intechopen.81697. DOI: https://doi.org/10.5772/intechopen.81697

Ajmal M, Friedman J, Sipra QU, Lassar T. Rivaroxaban: expanded role in cardiovascular disease management—a literature review. Cardiovascular Therapeutics. 2021 Jan; 2021: 1-9. doi: 10.1155/2021/8886210. DOI: https://doi.org/10.1155/2021/8886210

Vimalesvaran K, Dockrill SJ, Gorog DA. Role of rivaroxaban in the management of atrial fibrillation: insights from clinical practice. Vascular Health and Risk Management. 2018 Jan; 14: 13-21. doi: 10.2147/VHRM.S134394. DOI: https://doi.org/10.2147/VHRM.S134394

Vanassche T and Verhamme P. Rivaroxaban for the treatment of pulmonary embolism. Advances in Therapy. 2013 Jun; 30: 589-606. doi: 10.1007/s12325-013-0041-4. DOI: https://doi.org/10.1007/s12325-013-0041-4

Inoue H. Thromboembolism in patients with nonvalvular atrial fibrillation: comparison between Asian and Western countries. Journal of Cardiology. 2013 Jan; 61(1): 1-7. doi: 10.1016/j.jjcc.2012.08.012. DOI: https://doi.org/10.1016/j.jjcc.2012.08.012

Krohn-Grimberghe M, Bode C, Muhlen CV. Impact of rivaroxaban on stent thrombosis and secondary prevention of cardiovascular events in acute coronary syndrome. Research Reports in Clinical Cardiology. 2014 May; 5(2014): 103-9. doi: 10.2147/RRCC.S38727. DOI: https://doi.org/10.2147/RRCC.S38727

Petzold T, Thienel M, Dannenberg L, Mourikis P, Helten C, Ayhan A. Rivaroxaban reduces arterial thrombosis by inhibition of FXa-driven platelet activation via protease activated receptor-1. Circulation Research. 2020 Feb; 126(4): 486-500. doi: 10.1161/CIRCRESAHA.119.315099. DOI: https://doi.org/10.1161/CIRCRESAHA.119.315099

Yuksel M, Yildiz A, Tapan U, Ertas F, Alan S. Resolution of extensive coronary thrombosis under rivaroxaban treatment. Arquivos brasileiros de cardiologia. 2015 Dec; 105: 642-6. doi: 10.5935/abc.20150052. DOI: https://doi.org/10.5935/abc.20150052

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Published

2023-08-31
CITATION
DOI: 10.54393/pbmj.v6i08.927
Published: 2023-08-31

How to Cite

Tariq, A., Akhtar, B. . ., & Sharif, A. (2023). Rivaroxaban: Management of Coronary Artery Thrombosis in a Patient Presenting with Anterior Wall Myocardial Infarction: Rivaroxaban: Management of Coronary Artery Thrombosis. Pakistan BioMedical Journal, 6(08), 50–52. https://doi.org/10.54393/pbmj.v6i08.927

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