Impact of Essential Fatty Acids Consumption in Combating Neurological Disorders

Essential Fatty Acids & Neurological Disorders

Authors

  • Maria Aslam University Institute of Diet and Nutritional Sciences UIDNS, The University of Lahore, Lahore, Pakistan
  • Hira Mujeeb Mughal University Institute of Diet and Nutritional Sciences UIDNS, The University of Lahore, Lahore, Pakistan.
  • Shiza Rauf University Institute of Diet and Nutritional Sciences UIDNS, The University of Lahore, Lahore, Pakistan
  • Nawal Jamshaid University Institute of Diet and Nutritional Sciences UIDNS, The University of Lahore, Lahore, Pakistan.
  • Sofia Pervaiz University Institute of Diet and Nutritional Sciences UIDNS, The University of Lahore, Lahore, Pakistan
  • Rabiya Nadeem University Institute of Diet and Nutritional Sciences UIDNS, The University of Lahore, Lahore, Pakistan
  • Hafiza Namra Amjad University Institute of Diet and Nutritional Sciences UIDNS, The University of Lahore, Lahore, Pakistan.
  • Muniba Farooq University Institute of Diet and Nutritional Sciences UIDNS, The University of Lahore, Lahore, Pakistan
  • Areeba Khalid University Institute of Diet and Nutritional Sciences UIDNS, The University of Lahore, Lahore, Pakistan
  • Hammad Saeed Malik University Institute of Diet and Nutritional Sciences UIDNS, The University of Lahore, Lahore, Pakistan.
  • Shaista Jabeen University Institute of Diet and Nutritional Sciences UIDNS, The University of Lahore, Lahore, Pakistan.

DOI:

https://doi.org/10.54393/pbmj.v5i2.116

Abstract

Modernization of society have caused various momentous changes in dietary habits of people in this era of modern world. The modern dietary patterns are typically composed of Fatty acids mainly saturated fatty acids along with refined carbohydrates. This present-day diet together with a lifestyle with reduced physical activity is a major determinant of various metabolic disorders like obesity and diabetes. All these factors are also causing a gradual increase in the prevalence of cognitive disorders mainly depressive disorders and mood disorders. Neuroinflammation is the link between the metabolic disorders and cognitive disorders and this correlation is evident by significant clinical and epidemiological data. Fatty acids are of major interest as they have twofold functions. They are major contributors of modern diet causing obesity, diabetes and other metabolic disorders and on the other hand they serve as signaling molecules in the inflammatory responses. The difference lies in the choice of the fatty acids that are included as a part of daily diet. Saturated fatty acids are the ones should be avoided as they are the components of high caloric obesogenic diets whereas, polyunsaturated including Omega-6 and Omega-3 fatty acids must be consume through daily foods to prevent from Neuroinflammation considered to be the major cause of neuropsychiatric disorders.

References

Tiuca ID, Nagy K, Oprean R. Development and optimization of a gas-chromatographic separation method of fatty acids in human serum. World J Pharm Sci. 2015;3(8):1713-9.

Rustan AC, Drevon CA. Fatty acids: structures and properties. e LS. 2010 May 30.

Anez-Bustillos L, Dao DT, Baker MA, et al. Intravenous fat emulsion formulations for the adult and pediatric patient: understanding the differences. Nutr Clin Pract. 2016;31:596- 609

https://doi.org/10.1177/0884533616662996

Melo HM, Santos LE, Ferreira ST. Diet-derived fatty acids, brain inflammation, and mental health. Frontiers in neuroscience. 2019 Mar 26; 13:265.

https://doi.org/10.3389/fnins.2019.00265

Brouwer I, Wanders A & Katan M (2013). Trans fatty acids and cardiovascular health: research completed? European Journal of Clinical Nutrition 67(5): 1-7,

https://doi.org/10.1038/ejcn.2013.43

SK, Trepanier, MO, Bazinet, RP. n-3 Polyunsaturated fatty acids in animal models with neuroinflammation. Prostaglandins Leukot Essent Fatty Acids 2013; 88: 97-103.

https://doi.org/10.1016/j.plefa.2012.05.008

Liu Q, Zhang J. Lipid metabolism in Alzheimer's disease. Neurosci Bull. 2014;30(2):33145. DOI: 10.1007/s12264-013-1410-3

https://doi.org/10.1007/s12264-013-1410-3

Stapelberg NJ, Neumann DL, Shum DH, McConnell H, Hamilton-Craig I. A topographical map of the causal network of mechanisms underlying the relationship between major depressive disorder and coronary heart disease. Australian & New Zealand Journal of Psychiatry. 2011 May;45(5):351-69

https://doi.org/10.3109/00048674.2011.570427

Crupi R, Marino A, Cuzzocrea S. n-3 fatty acids: role in neurogenesis and neuroplasticity. Current medicinal chemistry. 2013 Aug 1;20(24):2953-63

https://doi.org/10.2174/09298673113209990140

Hackney C, Furness D. Introducing the cell: the unit of life. In: Orchard G, Nation B, editors. Cell Structure & Function. Glasgow: Oxford University Press; 2015

Lorente-Cebrián S, Costa AGV, Navas-Carretero S, Zabala M, Martínez JA, MorenoAliaga MJ. Role of omega-3 fatty acids in obesity, metabolic syndrome, and cardiovascular diseases: a review of the evidence. J PhysiolBiochem. 2013;69(3):633-51. DOI: 10.1007/s13105-013-0265-4

https://doi.org/10.1007/s13105-013-0265-4

Calder PC. Mechanisms of action of (n-3) fatty acids. The Journal of nutrition. 2012 Mar 1;142(3):592S-9S.

https://doi.org/10.3945/jn.111.155259

Xu Y. Development of a Novel Omega-6 Fatty Acid Based Treatment Strategy for Colon Cancer by Knocking Down Delta-5-Desaturase and Exploiting High COX-2 Levels in Cancer Cells/Tumors (Doctoral dissertation, North Dakota State University)

Salvini S, Parpinel M, Gnagnarella P, Maisonneuve P, Turrini A. Banca dati di composizione degli alimenti per studi epidemiologici in Italia.

U.S. Department of Agriculture, Agricultural Research Service. FoodData Central. 2019. Available online: https://fdc.nal.usda.gov (accessed on 16 January 2020).

Jones PHJ, Rideout T. Lipids, sterols, and their metabolites. In: Ross AC, Caballero B, Cousins RJ, Tucker KL, Ziegler TR. Modern Nutrition in Health and Disease. Lippincott, Williams and Wilkins. Philadelphia, PA. 2014;65-87.

Tappenden KA. Intake: digestion, absorption, transportation, and excretion of nutrients. In: Mahan LK, Raymond JL. Krause's Food & the Nutrition Care Process, 14th Edition. Elsevier. St. Louis, Missouri. 2017:2-16.

Kaur N, Chugh V, Gupta AK. Essential fatty acids as functional components of foods-a review. Journal of food science and technology. 2014 Oct;51(10):2289-303.

https://doi.org/10.1007/s13197-012-0677-0

Abedi E, Sahari MA. Long‐chain polyunsaturated fatty acid sources and evaluation of their nutritional and functional properties. Food science & nutrition. 2014 Sep;2(5):443-63.

https://doi.org/10.1002/fsn3.121

Ferreri C, Masi A, Sansone A, Giacometti G, Larocca AV, Menounou G, Scanferlato R, Tortorella S, Rota D, Conti M, Deplano S. Fatty acids in membranes as homeostatic, metabolic and nutritional biomarkers: recent advancements in analytics and diagnostics. Diagnostics. 2017 Mar;7(1):1.

https://doi.org/10.3390/diagnostics7010001

Aryal S, Hussain S, Drevon CA, Nagelhus E, Hvalby Ø, Jensen V, Walaas SI, Davanger S. Omega‐3 fatty acids regulate plasticity in distinct hippocampal glutamatergic synapses. European Journal of Neuroscience. 2019 Jan;49(1):40-50.

https://doi.org/10.1111/ejn.14224

Castro-Gómez P, Garcia-Serrano A, Visioli F, Fontecha J. Relevance of dietary glycerophospholipids and sphingolipids to human health. Prostaglandins, Leukotrienes and Essential Fatty Acids. 2015 Oct 1;101:41-51.

https://doi.org/10.1016/j.plefa.2015.07.004

Yehuda, S. Omega-6/omega-3 ratio and brain-related functions. World Rev Nutr Diet 2003; 92: 37-56.

https://doi.org/10.1159/000073791

Huang, TL. Omega-3 fatty acids, cognitive decline, and Alzheimer's disease: a critical review and evaluation of the literature. J Alzheimers Dis 2010; 21: 673-690

https://doi.org/10.3233/JAD-2010-090934

Fernández-Sanz P, Ruiz-Gabarre D, García-Escudero V. Modulating effect of diet on Alzheimer's disease. Diseases. 2019 Mar;7(1):12.

https://doi.org/10.3390/diseases7010012

Breijyeh Z, Karaman R. Comprehensive review on Alzheimer's disease: Causes and treatment. Molecules. 2020 Jan;25(24):5789.

https://doi.org/10.3390/molecules25245789

Morris MC, Tangney CC, Wang Y, Sacks FM, Bennett DA, Aggarwal NT. MIND diet associated with reduced incidence of Alzheimer's disease. Alzheimer's & Dementia. 2015 Sep 1;11(9):1007-14.

https://doi.org/10.1016/j.jalz.2014.11.009

Xicoy H, Wieringa B, Martens GJ. The role of lipids in Parkinson's disease. Cells. 2019 Jan;8(1):27.

https://doi.org/10.3390/cells8010027

Elfawy HA, Das B. Crosstalk between mitochondrial dysfunction, oxidative stress, and age related neurodegenerative disease: Etiologies and therapeutic strategies. Life sciences. 2019 Feb 1;218:165-84.

https://doi.org/10.1016/j.lfs.2018.12.029

Zheng, J, Huang, T, Yu, Y. Fish consumption and CHD mortality: an updated meta-analysis of seventeen cohort studies. Public Health Nutr 2012; 15: 725-737

https://doi.org/10.1017/S1368980011002254

Orr, SK, Trepanier, MO, Bazinet, RP. n-3 Polyunsaturated fatty acids in animal models with neuroinflammation. Prostaglandins Leukot Essent Fatty Acids 2013; 88: 97-103.

https://doi.org/10.1016/j.plefa.2012.05.008

Hauser RA, Lyons KE, Pahwa R. The UPDRS-8: a brief clinical assessment scale for Parkinson's disease. International journal of neuroscience. 2012 May 15;122(7):333-7.

https://doi.org/10.3109/00207454.2012.657381

Taghizadeh M, Tamtaji OR, Dadgostar E, Kakhaki RD, Bahmani F, Abolhassani J, Aarabi MH, Kouchaki E, Memarzadeh MR, Asemi Z. The effects of omega-3 fatty acids and vitamin E co-supplementation on clinical and metabolic status in patients with Parkinson's disease: A randomized, double-blind, placebo-controlled trial. Neurochemistry international. 2017 Sep 1;108:183-9.

https://doi.org/10.1016/j.neuint.2017.03.014

Valdearcos M, Robblee MM, Benjamin DI, Nomura DK, Xu AW, Koliwad SK. Microglia dictate the impact of saturated fat consumption on hypothalamic inflammation and neuronal function. Cell reports. 2014 Dec 24;9(6):2124-38.

https://doi.org/10.1016/j.celrep.2014.11.018

Pal, D., Dasgupta, S., Kundu, R., Maitra, S., Das, G., Mukhopadhyay, S., et al. Fetuin-A acts as an endogenous ligand of TLR4 to promote lipid induced insulin resistance. 2012.

https://doi.org/10.1038/nm.2851

Shpak G, Zylbertal A, Wagner S. Transient and sustained afterdepolarizations in accessory olfactory bulb mitral cells are mediated by distinct mechanisms that are differentially regulated by neuromodulators. Frontiers in cellular neuroscience. 2015.

https://doi.org/10.3389/fncel.2014.00432

Bazinet, R. P., and Layé, S. Polyunsaturated fatty acids and their metabolites in brain function and disease, 2014.

https://doi.org/10.1038/nrn3820

Hachem M, Géloën A, Van AL, Foumaux B, Fenart L, Gosselet F, Da Silva P, Breton G, Lagarde M, Picq M, Bernoud-Hubac N. Efficient docosahexaenoic acid uptake by the brain from a structured phospholipid. Molecular neurobiology. 2016 Jul.

https://doi.org/10.1007/s12035-015-9228-9

Chen X, Chen C, Fan S, Wu S, Yang F, Fang Z, Fu H, Li Y. Omega-3 polyunsaturated fatty acid attenuates the inflammatory response by modulating microglia polarization through SIRT1-mediated deacetylation of the HMGB1/NF-κB pathway following experimental traumatic brain injury. Journal of Neuroinflammation. 2018.

https://doi.org/10.1186/s12974-018-1151-3

Bozzatello P, Brignolo E, De Grandi E, Bellino S. Supplementation with omega-3 fatty acids in psychiatric disorders: a review of literature data. Journal of clinical medicine. 2016 Aug;5(8):67.

https://doi.org/10.3390/jcm5080067

Kleinridders, A., Cai, W., Cappellucci, L., Ghazarian, A., Collins, W. R., Vienberg, S. G., et al. Insulin resistance in brain alters dopamine turnover and causes behavioral disorders (2015).

https://doi.org/10.1073/pnas.1500877112

Fordahl SC, Jones SR. High-fat-diet-induced deficits in dopamine terminal function are reversed by restoring insulin signaling. ACS chemical neuroscience. 2017 Feb 15.

https://doi.org/10.1021/acschemneuro.6b00308

Perica MM, Delaš I. Essential fatty acids and psychiatric disorders. Nutrition in Clinical Practice. 2011 Aug;26(4):409-25.

https://doi.org/10.1177/0884533611411306

https://www.who.int/news-room/fact-sheets/detail/depression

Chandola HM, Tanna I. Role of omega-3 fatty acids in brain and neurological health with special reference to clinical depression. InOmega-3 fatty acids in brain and neurological health 2014 Jan 1 (pp. 163-179). Academic Press.

https://doi.org/10.1016/B978-0-12-410527-0.00014-4

Lotrich FE, Sears B, McNamara RK. Elevated ratio of arachidonic acid to long-chain omega-3 fatty acids predicts depression development following interferon-alpha treatment: relationship with interleukin-6. Brain, behavior, and immunity. 2013 Jul 1;31:48-53.

https://doi.org/10.1016/j.bbi.2012.08.007

Lespérance F, Frasure-Smith N, St-André E, Turecki G, Lespérance P, Wisniewski SR. The efficacy of omega-3 supplementation for major depression: a randomized controlled trial. The Journal of clinical psychiatry. 2010 Jun 15;71(8):0-.

https://doi.org/10.4088/JCP.10m05966blu

Patel KR, Cherian J, Gohil K, Atkinson D. Schizophrenia: overview and treatment options. Pharmacy and Therapeutics. 2014 Sep;39(9):638.

Hsu MC, Huang YS, Ouyang WC. Beneficial effects of omega-3 fatty acid supplementation in schizophrenia: possible mechanisms. Lipids in Health and Disease. 2020 Dec;19(1):1-7.

https://doi.org/10.1186/s12944-020-01337-0

Pawełczyk T, Grancow-Grabka M, Kotlicka-Antczak M, Trafalska E, Pawełczyk A. A randomized controlled study of the efficacy of six-month supplementation with concentrated fish oil rich in omega-3 polyunsaturated fatty acids in first episode schizophrenia. Journal of Psychiatric Research. 2016 Feb 1;73:34-44.

https://doi.org/10.1016/j.jpsychires.2015.11.013

Yehuda R, Hoge CW, McFarlane AC, Vermetten E, Lanius RA, Nievergelt CM, Hobfoll11 SE, Koenen12 KC, Neylan14 TC, Hyman13 SE. PRIMER.

Bisson JI, Cosgrove S, Lewis C, Roberts NP. Post-traumatic stress disorder. Bmj. 2015 Nov 26;351.

https://doi.org/10.1136/bmj.h6161

Kitamura T, Saitoh Y, Takashima N, Murayama A, Niibori Y, Ageta H, Sekiguchi M, Sugiyama H, Inokuchi K. Adult neurogenesis modulates the hippocampus-dependent period of associative fear memory. Cell. 2010 Nov 13;139(4):814-27.

https://doi.org/10.1016/j.cell.2009.10.020

Matsuoka Y. Clearance of fear memory from the hippocampus through neurogenesis by omega-3 fatty acids: a novel preventive strategy for posttraumatic stress disorder?. BioPsychoSocial medicine. 2011 Dec;5(1):1-9.

https://doi.org/10.1186/1751-0759-5-3

Aliev G, Beeraka NM, Nikolenko VN, Svistunov AA, Rozhnova T, Kostyuk S, Cherkesov I, Gavryushova LV, Chekhonatsky AA, Mikhaleva LM, Somasundaram SG. Neurophysiology and Psychopathology Underlying PTSD and Recent Insights into the PTSD Therapies-A Comprehensive Review. Journal of clinical medicine. 2020 Sep;9(9):2951.

https://doi.org/10.3390/jcm9092951

Anderson IM, Haddad PM, Scott J. Bipolar disorder. Bmj. 2012 Dec 27;345.

https://doi.org/10.1136/bmj.e8508

Matsuoka Y, Nishi D, Hamazaki K. Serum levels of polyunsaturated fatty acids and the risk of posttraumatic stress disorder. Psychotherapy and psychosomatics. 2013 Jan 1;82(6):408-10.

https://doi.org/10.1159/000351993

Grande I, Berk M, Birmaher B, Vieta E. Bipolar disorder. The Lancet. 2016 Apr 9;387(10027):1561-72.

https://doi.org/10.1016/S0140-6736(15)00241-X

Nordentoft M, Mortensen PB, Pedersen CB. Absolute risk of suicide after first hospital contact in mental disorder. Archives of general psychiatry. 2011 Oct 3;68(10):1058-64.

https://doi.org/10.1001/archgenpsychiatry.2011.113

Balanzá-Martínez V, Fries GR, Colpo GD, Silveira PP, Portella AK, Tabarés-Seisdedos R, Kapczinski F. Therapeutic use of omega-3 fatty acids in bipolar disorder. Expert review of neurotherapeutics. 2011 Jul 1;11(7):1029-47.

https://doi.org/10.1586/ern.11.42

Perica MM, Delaš I. Essential fatty acids, and psychiatric disorders. Nutrition in Clinical Practice. 2011 Aug;26(4):409-25.

https://doi.org/10.1177/0884533611411306

Ropper AH. Andre F. Carvalho, MD, Ph. D., Joseph Firth, Ph. D., and Eduard Vieta, MD, Ph. D. N Engl J Med. 2020;383:58-66.

https://doi.org/10.1056/NEJMra1906193

Gramlich L, Meddings L, Alberda C, et al. Essential fatty acid deficiency in 2015: the impact of novel intravenous lipid emulsions. JPEN J Parenter Enteral Nutr. 2015;39:61S-66S.

https://doi.org/10.1177/0148607115595977

Anez-Bustillos L, Dao DT, Baker MA, et al. Intravenous fat emulsion formulations for the adult and pediatric patient: understanding the differences. Nutr Clin Pract. 2016;31:596- 609.

https://doi.org/10.1177/0884533616662996

Mogensen KM. Essential fatty acid deficiency. Pract Gastroenterol. 2017 Jun 1;41(6):37-44.

McCray S, Parrish CR. Nutritional management of chyle leaks: an update. Pract Gastroenterol. 2011 Apr;94:12-32.

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Published

2022-02-28
CITATION
DOI: 10.54393/pbmj.v5i2.116
Published: 2022-02-28

How to Cite

Aslam, M., Mughal, H. M. ., Rauf, S. ., Jamshaid, N. ., Pervaiz, S. ., Nadeem, R. ., Amjad, H. N. ., Farooq, M. ., Khalid, A. ., Malik, H. S., & Jabeen, S. . (2022). Impact of Essential Fatty Acids Consumption in Combating Neurological Disorders: Essential Fatty Acids & Neurological Disorders. Pakistan BioMedical Journal, 5(2), 03–06. https://doi.org/10.54393/pbmj.v5i2.116

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