Role of Glucose Phosphate Deficiency in Neonatal Hyperbilirubinemia Among  Local Population of Pakistan: Glucose Phosphate Deficiency in Neonatal Hyperbilirubinemia

Abdul  Shakoor; Sadia  Bangash; Sadam  Hussain

doi:10.54393/pbmj.v5i1.284

Authors

Abdul Shakoor Health Department Punjab
Sadia Bangash Health Department KPK
Sadam Hussain Health Department Punjab

DOI:

https://doi.org/10.54393/pbmj.v5i1.284

Keywords:

Neonates, Deficiency, Hyperbilirubinemia

Abstract

Due to the prevalence of new-born jaundice (65%) and neonatal hyperbilirubinemia (85%) in the first 24 hours of life, Objectives of the study: The study's main purpose is to investigate G6PD insufficiency in neonates. Material and methods: The Punjab Health Department conducted a descriptive study from July to December 2021. The hospital's ethics committee approved this probe. The research included 197 patients. The research included infants aged 0-20 days. A survey was used to collect data. Gender, gestational age, age of presentation, and length of hospitalisation were all noted. Results: The study included 197 patients, 61 of whom were female and 136 males. Participants in this research had bilirubin levels between 10 and 30 mg/dl. The maximum age in this study was 18 days, while the minimum was a new-born infant. G6DP insufficiency was seen in 21 of the 197 patients. 176 individuals had normal G6PD levels. Conclusion: The study found that G6PD deficiency is common in new-borns. Severe hyperbilirubinemia has several risk factors

References

Koosha A, Rafizadeh B. Evaluation of neonatal indirect hyperbilirubinaemia at Zanjan Province of Iran in 2001-2003: prevalence of glucose-6-phosphate dehydrogenase deficiency. Singapore Med J. 2007;48:424-428.

Weng YH, Chiu YW. Clinical characteristics of G6PD deficiency in infants with marked hyperbilirubinemia. J Pediatr Hematol Oncol. 2010;32:11-14.

https://doi.org/10.1097/MPH.0b013e3181c09aec

Atay E, Bozaykut A, Ipek IO. Glucose-6-phosphate dehydrogenase deficiency in neonatal indirect hyperbilirubinemia. J Trop Pediatr. 2006;52:56-58.

https://doi.org/10.1093/tropej/fmi042

Rice AC, Shapiro SM. A new animal model of hemolytic hyperbilirubinemia-induced bilirubin encephalopathy (kernicterus) Pediatr Res. 2008;64:265-269.

https://doi.org/10.1203/PDR.0b013e31817d9be0

American Academy of Pediatrics Subcommittee on Hyperbilirubinemia. Management of hyperbilirubinemia in the newborn infant 35 or more weeks of gestation. Pediatrics. 2004;114:297-316.

https://doi.org/10.1542/peds.114.1.297

Cappellini MD, Fiorelli G. Glucose-6-phosphate dehydrogenase deficiency. Lancet. 2008;371:64-74.

https://doi.org/10.1016/S0140-6736(08)60073-2

Al Arrayed S. Frequency of G6PD deficiency among Bahraini students: a ten years' study. Bah Med Bull. 2010;32:18-21.

Ainoon O, Joyce J, Boo NY, Cheong SK, Zainal ZA, Hamidah NH. Glucose-6-phosphate dehydrogenase (G6PD) variants in Malaysian Chinese. Hum Mutat. 1999;14:352.

https://doi.org/10.1002/(SICI)1098-1004(199910)14:4<352::AID-HUMU14>3.0.CO;2-G

Agrawal SK, Kumar P, Rathi R, Sharma N, DAS R, Prasad R, et al. UGT1A1 gene polymorphisms in North Indian neonates presenting with unconjugated hyperbilirubinemia. Pediatr Res. 2009;65:675-680.

https://doi.org/10.1203/PDR.0b013e31819ed5de

Moiz B, Nasir A, Khan SA, Kherani SA, Qadir M. Neonatal hyperbilirubinemia in infants with G6PD c.563C > T Variant. BMC Pediatr. 2012;12:126.

https://doi.org/10.1186/1471-2431-12-126

Samanta S, Kumar P, Kishore SS, Garewal G, Narang A. Donor blood glucose 6-phosphate dehydrogenase deficiency reduces the efficacy of exchange transfusion in neonatal hyperbilirubinemia. Pediatrics. 2009;123:e96-e100.

https://doi.org/10.1542/peds.2008-2021

Isa, H. M., Mohamed, M. S., Mohamed, A. M., Abdulla, A., & Abdulla, F. (2017). Neonatal indirect hyperbilirubinemia and glucose-6-phosphate dehydrogenase deficiency. Korean journal of pediatrics, 60(4), 106-111. https://doi.org/10.3345/kjp.2017.60.4.106

https://doi.org/10.3345/kjp.2017.60.4.106

Samanta S, Kumar P, Kishore SS, Garewal G, Narang A. Donor blood glucose 6-phosphate dehydrogenase deficiency reduces the efficacy of exchange transfusion in neonatal hyperbilirubinemia. Pediatrics. 2009;123:e96-e100.

https://doi.org/10.1542/peds.2008-2021

Ali N, Anwar M, Ayub M, Nadeem M, Bhatti FA, Nadeem A. Frequency of Glucose 6 Phosphate Dehydrogenase deficiency in some ethnic groups of Pakistan.. J Coll Physician Surg Pak 2005;15:137-41.

Anderle A, Bancone G, Domingo GJ, Gerth-Guyette E, Pal S, Satyagraha AW. Point-of-Care Testing for G6PD Deficiency: Opportunities for Screening. International Journal of Neonatal Screening. 2018; 4(4):34. https://doi.org/10.3390/ijns4040034

https://doi.org/10.3390/ijns4040034

Elhalik M, El-Atawi K, Dash S, et al. Incidence of G6PD deficiency among neonates with hyperbilirubinemia requiring phototherapy at postnatal wards of a tertiary care perinatal center, Dubai, UAE: A longitudinal cross-sectional study. J Pediatr Neonatal Care. 2020;10(5):134-137. DOI: 10.15406/jpnc.2020.10.00425

https://doi.org/10.15406/jpnc.2020.10.00425

Alharbi KK, Khan IA. Prevalence of glucose-6-phosphate dehydrogenase deficiency and the role of the A− variant in a Saudi population. J Int Med Res. 2014;42(5):1161-1167.

https://doi.org/10.1177/0300060514531923

Slusher TM, Zamora TG, Appiah D, et al. Burden of severe neonatal jaundice: A systematic review and meta-analysis. BMJ Paediatr Open. 2017;1.

https://doi.org/10.1136/bmjpo-2017-000105

Isa HM, Mohamed MS, Mohamed AM, et al. Neonatal indirect hyperbilirubinemia and glucose-6-phosphate dehydrogenase deficiency. Korean J Pediatr. 2017;60:106-111.

https://doi.org/10.3345/kjp.2017.60.4.106

Abdul-Ghani R, Mahdy MAK, Saif-Ali R, et al. Glucose-6-phosphate dehydrogenase deficiency among Yemeni children residing in malaria-endemic areas of Hodeidah governorate and evaluation of a rapid diagnostic test for its detection. Malar J. 2016;15.

https://doi.org/10.1186/s12936-016-1372-9