A Review of Oral Lichen Planus and its  Management with Herbal Treatment: OLP with herbal treatment

Madiha khan niazi; Kinza  Jalal; Huma Amjad; Sana  Jamshed; Sahar Imran; Wajeeha Arooj; Nizwa Choudhary; Farooq Hassan

doi:10.54393/pbmj.v5i5.287

Authors

Madiha khan niazi University of Lahore
Kinza Jalal University Institute of Diet and Nutritional sciences ,Faculty of Allied health sciences, The university of Lahore, Pakistan.
Huma Amjad
Sana Jamshed University Institute of Diet and Nutritional sciences ,Faculty of Allied health sciences, The university of Lahore, Pakistan.
Sahar Imran
Wajeeha Arooj
Nizwa Choudhary
Farooq Hassan Punjab Healthcare Commission, Lahore, Pakistan

DOI:

https://doi.org/10.54393/pbmj.v5i5.287

Keywords:

oral lichen planus, Immunity, oral lichenoid lesions, Therapeutic algorithm, herbal medicine

Abstract

Oral lichen planus is an inflammatory disorder that affects the mouth. Oral mucosa primarily affects women in their forties and fifties. OLP is a localised autoimmune disorder caused by T-cell malfunction, according to previous research. The tongue, buccal mucosa, and gingiva are the most prevalent sites for OLP. The distribution of oral lesions is always symmetrical and bilateral. Oral leukoplakia and oral erythro leukoplakia might be mistaken for plaque-like and atrophic/erosive OLP, respectively. Because OLP is an immunologically mediated condition, corticosteroids are the most effective treatment. Herbal medicine, which has anti-inflammatory and antioxidant qualities, appears to be a viable alternative therapy. As a result, the goal of this research was to describe the efficacy of different OLP treatments.

References

Alrashdan MS, Cirillo N, McCullough M. Oral lichen planus: a literature review and update. Archives of dermatological research. 2016 Oct;308(8):539-51.

Boorghani M, Gholizadeh N, Zenouz AT, Vatankhah M, Mehdipour M. Oral lichen planus: clinical features, etiology, treatment and management; a review of literature. Journal of dental research, dental clinics, dental prospects. 2010;4(1):3.

Chainani-Wu N, Madden E, Lozada-Nur F, Silverman Jr S. High-dose curcuminoids are efficacious in the reduction in symptoms and signs of oral lichen planus. Journal of the American Academy of Dermatology. 2012 May 1;66(5):752-60.

Amirchaghmaghi M, Hashemy SI, Alirezaei B, Keyhani FJ, Kargozar S, Vasigh S, Gharaei S, Pakfetrat A. Evaluation of plasma isoprostane in patients with oral lichen planus. Journal of dentistry. 2016 Mar;17(1):21.

Hashemy SI, Gharaei S, Vasigh S, Kargozar S, Alirezaei B, Jahed Keyhani F, Amirchaghmaghi M. Oxidative stress factors and C‐reactive protein in patients with oral lichen planus before and 2 weeks after treatment. Journal of Oral Pathology & Medicine. 2016 Jan;45(1):35-40.

Babaee N, Zabihi E, Mohseni S, Moghadamnia AA. Evaluation of the therapeutic effects of Aloe vera gel on minor recurrent aphthous stomatitis. Dental research journal. 2012 Jul;9(4):381.

Cheng YS, Gould A, Kurago Z, Fantasia J, Muller S. Diagnosis of oral lichen planus: a position paper of the American Academy of Oral and Maxillofacial Pathology. Oral surgery, oral medicine, oral pathology and oral radiology. 2016 Sep 1;122(3):332-54.

Amirchaghmaghi M, Delavarian Z, Iranshahi M, Shakeri MT, Mozafari PM, Mohammadpour AH, Farazi F, Iranshahy M. A randomized placebo-controlled double blind clinical trial of quercetin for treatment of oral lichen planus. Journal of dental research, dental clinics, dental prospects. 2015;9(1):23.

Das S, Bordoloi R, Newar N. A review on immune modulatory effect of some traditional medicinal herbs. Journal of Pharmaceutical, Chemical and Biological Sciences. 2014 May;2(1):33-42.

Vibha JB, Choudhary K, Singh M, Rathore MS, Shekhawat NS. A study on pharmacokinetics and therapeutic efficacy of Glycyrrhiza glabra: a miracle medicinal herb. Botany Research International. 2009;2(3):157-63.

Resende JP, Chaves MD, Aarestrup FM, Aarestrup BV, Olate S, Netto HD. Oral lichen planus treated with tacrolimus 0.1%. International journal of clinical and experimental medicine. 2013;6(10):917.

Ali S, Wahbi W. The efficacy of aloe vera in management of oral lichen planus: a systematic review and meta‐analysis. Oral diseases. 2017 Oct;23(7):913-8.

Eisenberg DM, Davis RB, Ettner SL, Appel S, Wilkey S, Van Rompay M, Kessler RC. Trends in alternative medicine use in the United States, 1990-1997: results of a follow-up national survey. Jama. 1998 Nov 11;280(18):1569-75.

Chiu CT, Chuang CY, Li JR, Huang HY, Chang SW, Hung YC. Greater therapeutic efficacy of prednisolone plus medicinal herbs than prednisolone or medicinal herbs alone in patients with oral lichen planus. Journal of Dental Sciences. 2010 Dec 1;5(4):209-15.

Carbone M, Goss E, Carrozzo M, Castellano S, Conrotto D, Broccoletti R, Gandolfo S. Systemic and topical corticosteroid treatment of oral lichen planus: a comparative study with long‐term follow‐up. Journal of oral pathology & medicine. 2003 Jul;32(6):323-9.

Li-mei L, Xiang-min Q. Comparative observation on the effects of Radix tripterygium hypoglaucum tablet and Tripterygium glycosides tablet in treating erosive oral lichen planus. Chinese journal of integrative medicine. 2005 Jun 1;11(2):149-50.

Ma FK. Comparison of catechu and Tripterygium hypoglaucum hutch tablet in treating oral lichen planus of erosion type. Shanghai kou qiang yi xue= Shanghai journal of stomatology. 2004 Aug 1;13(4):348-9.

Sugerman P, Savage NW, Walsh LJ, Zhao ZZ, Zhou XJ, Khan A, Seymour GJ, Bigby M. The pathogenesis of oral lichen planus. Critical Reviews in Oral Biology & Medicine. 2002 Jul;13(4):350-65.

Zhao ZZ, Savage NW, Sugerman PB, Walsh LJ. Mast cell/T cell interactions in oral lichen planus. J Oral Pathol Med 2002;31: 189-95.

Hirota J, Osaki T, Tatemoto Y. Immunohistochemical staining of infiltrates in oral lichen planus. Path Res Pract 1990;186: 625-32.

Yamamoto T, Yoneda K, Ueta E, Osaki T. Cellular immunosuppression in oral lichen planus. J Oral Pathol Med 1990;19: 464-70.

Scully C, Beyli M, Ferreiro MC, Ficarra G, Gill Y, Griffiths M, et al. Update on oral lichen planus: etiopathogenesis and management. Crit Rev Oral Biol Med 1998;9:86-122.

Mollaoglu N. Oral lichen planus: a review. Br J Oral Maxillofac Surg 2000;38:370-7.

Cheng YSL, Gould A, Kurago Z, Fantasia J, Muller S. Diagnosis of oral lichen planus: a position paper of the American academy of oral and maxillofacial pathology. Oral Surg Oral Med Oral Pathol Oral Radiol 2016;122:332-54

Carrozzo M, Porter S, Mercadante V, Fedele S. Oral lichen planus: A disease or a spectrum of tissue reactions? Types, causes, diagnostic algorhythms, prognosis, management strategies. Periodontology 2000. 2019 Jun;80(1):105-25.

Rai B, Kharb S, Jain R, Anand SC. Salivary lipid peroxidation product malonaldehyde in various dental diseases. World J Med Sci. 2006;1(2):100-.

Shirzad A, Pouramir M, Seyedmajidi M, Jenabian N, Bijani A, Motallebnejad M. Salivary total antioxidant capacity and lipid peroxidation in patients with erosive oral lichen planus. Journal of dental research, dental clinics, dental prospects. 2014;8(1):35.

Halliwell B. Free radicals and antioxidants: updating a personal view. Nutrition reviews. 2012 May 1;70(5):257-65.

Halliwell B. Antioxidants in human health and disease. Annual review of nutrition. 1996 Jul;16(1):33-50.

Carbone M, Goss E, Carrozzo M et al. Systemic and topical corticosteroid treatment of oral lichen planus: a comparative study with longterm follow-up. J Oral Pathol Med 2003; 32: 323–329.

Silverman S Jr, Gorsky M, Lozada-Nur F, Giannotti K. A prospective study of findings and management in 214 patients with oral lichen planus. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 1991; 72: 665– 670.

Giustina TA, Stewart JC, Ellis CN et al. Topical application of isotretinoin gel improves oral lichen planus. Arch Dermatol 1986; 122: 534–536.

Yoke PC, Tin GB, Kim MJ et al. Asian Lichen Planus Study Group. A randomized controlled trial to compare steroid with cyclosporine for the topical treatment of oral lichen planus. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2006; 102: 47–55.

Conrotto D, Carbone M, Carrozzo M et al. Ciclosporin vs. clobetasol in the topical management of atrophic and erosive oral lichen planus: a double-blind, randomized controlled trial. Br J Dermatol 2006; 154: 139–145.

Shilpa PS, Kaul R, Bhat S, Sanjay CJ, Sultana N. Topical tacrolimus in the management of oral lichen planus: literature review. J Calif Dent Assoc 2014; 42: 165–170.

McCaughey C, Machan M, Bennett R, Zone JJ, Hull CM. Pimecrolimus 1% cream for oral erosive lichen planus: a 6-week randomized, doubleblind, vehicle-controlled study with a 6-week open-label extension to assess efficacy and safety. J Eur Acad Dermatol Venereol 2011; 25: 1061– 1067.

Giuliani M, Troiano G, Cordaro M et al. Rate of malignant transformation of oral lichen planus: A systematic review. Oral Dis 2019; 25: 693– 70.

Cheng S, Kirtschig G, Cooper S et al. Interventions for erosive lichen planus affecting mucosal sites. Cochrane Database Syst Rev 2012; 15:

Liu P, Cheng H, Roberts TM, Zhao JJ. Targeting the phosphoinositide 3-kinase pathway in cancer. Nature reviews Drug discovery. 2009 Aug;8(8):627-44.

Soltani A, Salmaninejad A, Jalili‐Nik M, Soleimani A, Javid H, Hashemy SI, Sahebkar A. 5′‐Adenosine monophosphate‐activated protein kinase: A potential target for disease prevention by curcumin. Journal of cellular physiology. 2019 Mar;234(3):2241-51.

Das S, Bordoloi R, Newar N. A review on immune modulatory effect of some traditional medicinal herbs. Journal of Pharmaceutical, Chemical and Biological Sciences. 2014 May;2(1):33-42.

Agha‐Hosseini F, Borhan‐Mojabi K, Monsef‐Esfahani HR, Mirzaii‐Dizgah I, Etemad‐Moghadam S, Karagah A. Efficacy of purslane in the treatment of oral lichen planus. Phytotherapy Research: An International Journal Devoted to Pharmacological and Toxicological Evaluation of Natural Product Derivatives. 2010 Feb;24(2):240-4.

Chiu CT, Chuang CY, Li JR, Huang HY, Chang SW, Hung YC. Greater therapeutic efficacy of prednisolone plus medicinal herbs than prednisolone or medicinal herbs alone in patients with oral lichen planus. Journal of Dental Sciences. 2010 Dec 1;5(4):209-15.

Vickers, E. R., & Woodcock, K. L.. Raspberry leaf herbal extract significantly reduces pain and inflammation in oral lichen planus patients— A case series analysis. Open Journal of Dentistry and Oral Medicine, 2015, 3(3), 73–81.

Saawarn N, Shashikanth MC, Saawarn S, Jirge V, Chaitanya NC, Pinakapani R. Lycopene in the management of oral lichen planus: A placebo-controlled study. Indian Journal of Dental Research. 2011 Sep 1;22(5):639.

Nevil, B. W., D. D. Damm, C. M. Allen, and A. C. Chi. "Oral and Maxillofacial Pathology 4th ed. philadelphia: WB." 2016: 385-386..