Evaluating the Anti-Diabetic Effect of Ginger Powder in Experimental Rats

Anti-Diabetic Effect of Ginger Powder in Experimental Rats

Authors

  • Maryam Maqsood University Institute of Diet and Nutritional Sciences, The University Of Lahore, Lahore, Punjab-Pakistan
  • Huma Bader Ul Ain University Institute of Diet and Nutritional Sciences, The University Of Lahore, Lahore, Punjab-Pakistan
  • Tabussam Tufail University Institute of Diet and Nutritional Sciences, The University Of Lahore, Lahore, Punjab-Pakistan
  • Shazia Bibi University Institute of Diet and Nutritional Sciences, The University Of Lahore, Lahore, Punjab-Pakistan
  • Baila Ahmad Department of Food Science and Technology, The Islamia University of Bahawalpur
  • Sahar Imran University Institute of Diet and Nutritional Sciences, The University Of Lahore, Lahore, Punjab-Pakistan
  • Javaria Kanwal Department of Food Science and Technology, The Islamia University of Bahawalpur
  • Mehboob Ali University Institute of Diet and Nutritional Sciences, The University Of Lahore, Lahore, Punjab-Pakistan
  • Nabia Ijaz University Institute of Diet and Nutritional Sciences, The University Of Lahore, Lahore, Punjab-Pakistan
  • Saleha Ahmad University Institute of Diet and Nutritional Sciences, The University Of Lahore, Lahore, Punjab-Pakistan

DOI:

https://doi.org/10.54393/pbmj.v5i3.333

Keywords:

Diabetes mellitus, Ginger, Liver functioning test, glucose, insulin

Abstract

In the current research paper, the effect of ginger powder on diabetic rats was probed. The bio-adequacy study was observed on Alloxan prompted Wistar rodents by taking ginger powder at three levels for example 1%, 3% and 5% ginger powder for a time of about a month. There were 4 gatherings (one was control and the other three getting various rates of ginger powder), each containing 5 rodents. The blood tests were gathered at multi day, fifteenth day and 28th day. Glucose and insulin levels were estimated. The information in this manner acquired was genuinely investigated to discover the degree of importance. Results showed that glucose levels essentially diminished alongside critical expansion in insulin levels. This examination configuration infers that ginger powder has constructive outcomes in bringing down glucose levels. Subsequently, use of ginger powder and ginger tea ought to be expanded in diabetic patients to diminish hyperglycemia in diabetic patients and defeat from high BSL levels in pre-diabetics. The conclusive results of this study were that ginger powder effected and show anti-diabetic effects as mean values of glucose levels dropped from 362.35±25.61 to 117.94±10.96. Proximate analysis showed that ginger powder contains ash, moisture, crude fat, crude fiber and crude protein content as 6.5% ± 0.31, 19.9% ± 1.50, 12.6% ± 0.50, 5.2% ± 0.11, 9.9% ± 0.34 respectively. Moreover, in liver functions, ALP, ALT, AST were examined resulting as a drop in mean values from 154.20±11.86 to 153.89±11.53, from 51.93±4.32 to 50.68±4.15 and from 106.77±12.85 to 110.26±11.54 respectively.

References

Arablou, T., N. Aryaeian, M. Valizadeh, F. Sharifi, A. Hosseini, and M. Djalali. The effect of Ginger Consumption on Glycemic Status Lipid Profile and Some Inflammatory Markers in Patients with Type 2 Diabetes Mellitus. Int. J. Food Sci. Nutr. 2014. 65(4):515. doi:10.3109/09637486.2014.880671.

Labib, M., E. Sargent and S. Kelley. Electrochemical Methods for the Analysis of Clinically Relevant Biomolecules. Chem. Rev. 2016 116(16):90. doi:10.1021/acs.chemrev.6b00220

Bhandari, U., R. kanojia, and K.K. Pillai. Effect of Ethanolic Extract of Zingiber Officinale on Dyslipidaemia in Diabetic Rats. J. Ethnopharm. 2005. 97(2):230. doi: https://doi.org/10.1016/j.jep.2004.11.011.

Seyer, M., and P. Gélinas. Bran Characteristics and Wheat Performance in Whole Wheat Bread. Int. J. Food Sci. Tech. 2009. 44(4):688. doi: https://doi.org/10.1111/j.1365-2621.2008.01819.x.

Akdogan, H., M. Tilley and K. Chung. Effect of Emulsifiers on Textural Properties of Whole Wheat Tortillas during Storage-Cereal Chem. 2006. 83(6):635. doi: https://pubag.nal.usda.gov/download/20511/PDF.

Amir, R., M. Anjum, I. Khan, R. Khan, I. Pasha and M. Nadeem. Application of Fourier Transform Infrared FTIR Spectroscopy for the Identification of Wheat Varieties. J. Food Sci. Tech. 2013. 50(5):10. doi:10.1007/s13197-011-0424-y.

Aboshora, W., Z. Lianfu, M. Dahir, M. Qingran, A. Musa, M. Gasmalla and A. Omar. Influence of Doum Hyphaene Thebaica L Flour Addition on Dough Mixing Properties Bread Quality and Antioxidant Potential. J. Food Sci. Tech. 2016. 53(1):591. doi: 10.1007/s13197-015-2063-1.

Gaspar, M., W. Couet, J. Olivier, A. Pais and J. Sousa. Pseudomonas aeruginosa infection in cystic fibrosis lung disease and new perspectives of treatment a review-Eur. J. Clin. Microbio. Inf. Dis. 2013 32(10):1231.

Deeds, M., J. Anderson, A. Gastineau, D. Hiddinga, J. Jahangir, and Y.C. Kudva. Single dose streptozotocin induced diabetes considerations for study design in islet transplantation models. J. Lab. Ani. 2011. 45(3):131. doi:10.1258/la.2010.010090.

Parasuraman. S., R. Raveendran, and R. Kesavan. Blood Sample Collection in Small Laboratory Animals. J. Pharm. Pharmacotherap. 1(2):87. doi: 10.4103/0976-500X.72350.

Sämann. A., I. Mühlhauser, R. Bender, C. Kloos, and U. Müller. Glycaemic control and severe hypoglycaemia following training in flexible intensive insulin therapy to enable dietary freedom in people with type 1 diabetes a prospective implementation study-Diabetologia. 2010. 48(10)1965. doi: 10.1007/s00125-005-1905-1.

Katz, A., S. Nambi, K. Mather, A. Baron, D. Follmann, G. Sullivan and J. Quon. Quantitative Insulin Sensitivity Check Index a Simple Accurate Method for Assessing Insulin Sensitivity in Humans. J. Clin. Endocrinol. Metab. 2000. 85(7):2402.

Ahn, J., W. Kim and S. Ha. Anti-diabetic Effect of Watermelon Citrullus Vulgaris Schrad on Streptozotocin-Induced Diabetic Mice. Food Sci. Biotech. 2011. 20(1):251-54.

Mahluji, S., E. Attari, M. Mobasseri, L. Payahoo, A. Ostadrahimi, E. Golzari. Effects of Ginger Zingiber officinale on Plasma Glucose Level HbA1c and Insulin Sensitivity in Type 2 Diabetic Patients. Int. J. Food Sci. Nutr. 2013. 64(6):682. doi:10.3109/09637486.2013.775223.

Rong, X., G. Peng, T. Suzuki, Q. Yang, J. Yamahara, Y. Li. A 35 Day Gavage Safety Assessment of Ginger in Rats. Regulatory Toxicology and Pharmacology. 2009. 54(2):118. doi:10.1016/j.yrtph.2009.03.002.

Elkott A., Sayed F., and Aziz, A. The effects of Ginger Zingiber officinale on Histology and Immunohistochemistry of Liver and Kidney and Certain Haematological Parameters in Alloxan Induced Diabetic Rats. Egypt. J. Exp. Biology 6(1), 61. doi:https://www.bibliomed.org/?mno=187702.

Mahluji. S., E. Attari, M. Mobasseri, L. Payahoo, A. Ostadrahimi and S. Golzari. Effects of ginger Zingiber officinale on Plasma Glucose Level HbA1c and Insulin Sensitivity in Type 2 Diabetic Patients. Int. J. Food Sci. Nutr. 2013. 64(6):682. doi: 10.3109/09637486.2013.775223.

Ercan. M., B. Bostanci, Z. Teke, K. Karaman, T. Dalgic, M. Ulas, I. Ozer, B. Ozogul, F. Atalay and M. Akoglu. Predictive Factors for Conversion to Open Surgery in Patients undergoing Elective Laparoscopic Cholecystectomy. J. Laparoendosco. Adv. Surg. Tech. 2010 20(5):427-34. doi:10.1089/lap.2009.0457.

Kostadinova, R., F. Boess, D. Applegate, L. Suter, T. Weiser, T. Singer and Roth A. E. A Long Term Three Dimensional Liver Co Culture System for Improved Prediction of Clinically Relevant Drug Induced Hepatotoxicity. Toxicology and applied pharmacology. 2013. 268(1):1-16. doi: 10.1016/j.taap.2013.01.012.

Jain, H. Screening of Juniperus Communis Linnolinic Oil for Anthelmintic Wound Healing and Hepatoprotective Activities in Rats. Doctoral dissertation RGUHS. 2010. 16(1):142 doi:10.1177/0748233712469995.

Wilkinson J. and Penicillin L. Induced liver injury case report-Reactions. 2016. 1614(34):13. doi:10.1007/s10620-016-4121-6

Downloads

Published

2022-03-31
CITATION
DOI: 10.54393/pbmj.v5i3.333
Published: 2022-03-31

How to Cite

Maqsood, M. ., Bader Ul Ain, H. ., Tufail, T. ., Bibi, S. ., Ahmad, B. ., Imran, S. ., Kanwal, J. ., Ali, M. ., Ijaz, N. ., & Ahmad, S. . (2022). Evaluating the Anti-Diabetic Effect of Ginger Powder in Experimental Rats: Anti-Diabetic Effect of Ginger Powder in Experimental Rats. Pakistan BioMedical Journal, 5(3), 129–133. https://doi.org/10.54393/pbmj.v5i3.333

Issue

Section

Original Article

Plaudit

Most read articles by the same author(s)

1 2 3 > >>