Monkey Pox: An Emerging Outbreak : Monkey Pox: An Emerging Outbreak

Hafiza Arshi Saeed; Aqsa Perveen; Ayesha Haidar; Hafiza Rida Fatima; Rameen Atique; Maria Aslam; Areesha Naveed; Javeria Sharif; Abdul Samad

doi:10.54393/pbmj.v6i12.982

Authors

Hafiza Arshi Saeed Department of Pathobiology, FVAS, MNS University of Agriculture, Multan Pakistan
Aqsa Perveen Department of Pathobiology, FVAS, MNS University of Agriculture, Multan Pakistan
Ayesha Haidar Department of Pathobiology, FVAS, MNS University of Agriculture, Multan Pakistan
Hafiza Rida Fatima Department of Pathobiology, FVAS, MNS University of Agriculture, Multan Pakistan
Rameen Atique Department of Pathobiology, FVAS, MNS University of Agriculture, Multan Pakistan
Maria Aslam Department of Pathobiology, FVAS, MNS University of Agriculture, Multan Pakistan
Areesha Naveed Department of Pathobiology, FVAS, MNS University of Agriculture, Multan Pakistan
Javeria Sharif Department of Pathobiology, FVAS, MNS University of Agriculture, Multan Pakistan
Abdul Samad Department of Animal Sciences, Gyeongsang National University, Jinju-Si, South Korea

DOI:

https://doi.org/10.54393/pbmj.v6i12.982

Keywords:

Monkeypox Virus, Zoonotic Diseases, JYNNEOSTM Vaccine

Abstract

Monkeypox is a viral disease, with very rare cases. It has gained attention because of its similarities to smallpox. It was diagnosed in 1958 for the first time in monkeys and then later this disease effected people of Africa who were living in the western and central parts of Africa. The virus is liable for monkeypox, an orthopoxvirus, and is generally transmitted to people through contact with animals such as rodents, monkeys, and different wildlife. Human-to-human transmission can occur, mainly in localized outbreaks. Although monkeypox is sporadic and typically considered a zoonotic disease, it has caused epidemics in Central and West Africa. These outbreaks are often connected to close touch with infected animals, especially in rural communities. Some common symptoms include rash, fever, and pustules. While the mortality rate of this disease is 1-10% which is less than small pox. Treatment includes addressing signs such as fever, pain, and skin lesions. Patients may also require hospitalization, especially if they develop extreme complications, and have to be isolated to prevent human-to-human transmission. Research into antiviral medicinal drugs and vaccines is ongoing; however, in September 2021, no licensed monkeypox-specific antiviral drugs or vaccines were available. Preventing monkeypox generally includes decreasing the risk of exposure to the virus. Key preventive measures include people in endemic regions reducing contact with animals that carry the virus, including rodents and monkeys. This review provides an overview of monkeypox, focusing on its epidemiology, treatment, and prevention strategies.

References

Gessain A, Nakoune E, Yazdanpanah Y. Monkeypox. New England Journal of Medicine. 2022 Nov; 387(19): 1783-93. doi: 10.1056/NEJMra2208860. DOI: https://doi.org/10.1056/NEJMra2208860

Reynolds MG, Doty JB, McCollum AM, Olson VA, Nakazawa Y. Monkeypox re-emergence in Africa: a call to expand the concept and practice of One Health. Expert Review of Anti-infective Therapy. 2019 Feb; 17(2): 129-39. doi: 10.1080/14787210.2019.1567330. DOI: https://doi.org/10.1080/14787210.2019.1567330

Brown K and Leggat PA. Human monkeypox: current state of knowledge and implications for the future. Tropical Medicine and Infectious Disease. 2016 Dec; 1(1): 8. doi: 10.3390/tropicalmed1010008. DOI: https://doi.org/10.3390/tropicalmed1010008

Smith KO and Sharp DG. Interaction of virus with cells in tissue cultures: I. Adsorption on and growth of vaccinia virus in L cells. Virology. 1960 Jul; 11(3): 519-32. doi: 10.1016/0042-6822(60)90097-0. DOI: https://doi.org/10.1016/0042-6822(60)90097-0

Arita I and Henderson DA. Smallpox and monkeypox in non-human primates. Bulletin of the World Health Organization. 1968; 39(2): 277.

Rouhandeh H, Engler R, Taher M, Fouad A, Sells LL. Properties of monkey pox virus. Archiv für die Gesamte Virusforschung. 1967 Sep; 20: 363-73. doi: 10.1007/BF01241954. DOI: https://doi.org/10.1007/BF01241954

Nolen LD, Osadebe L, Katomba J, Likofata J, Mukadi D, Monroe B et al. Extended human-to-human transmission during a monkeypox outbreak in the Democratic Republic of the Congo. Emerging Infectious Diseases. 2016 Jun; 22(6): 1014. doi: 10.3201/eid2206.150579. DOI: https://doi.org/10.3201/eid2206.150579

Reed KD, Melski JW, Graham MB, Regnery RL, Sotir MJ, Wegner MV et al. The detection of monkeypox in humans in the Western Hemisphere. New England Journal of Medicine. 2004 Jan; 350(4): 342-50. doi: 10.1056/NEJMoa032299. DOI: https://doi.org/10.1056/NEJMoa032299

Reynolds MG and Damon IK. Outbreaks of human monkeypox after cessation of smallpox vaccination. Trends in Microbiology. 2012 Feb; 20(2): 80-7. doi: 10.1016/j.tim.2011.12.001 DOI: https://doi.org/10.1016/j.tim.2011.12.001

Hraib M, Jouni S, Albitar MM, Alaidi S, Alshehabi Z. The outbreak of monkeypox 2022: An overview. Annals of Medicine and Surgery. 2022 Jul; 79: 104069. doi: 10.1016/j.amsu.2022.104069. DOI: https://doi.org/10.1016/j.amsu.2022.104069

Vaughan A, Aarons E, Astbury J, Brooks T, Chand M, Flegg P et al. Human-to-human transmission of monkeypox virus, United Kingdom, October 2018. Emerging Infectious Diseases. 2020 Apr; 26(4): 782. doi: 10.3201/eid2604.191164. DOI: https://doi.org/10.3201/eid2604.191164

Weinstein RA, Nalca A, Rimoin AW, Bavari S, Whitehouse CA. Reemergence of monkeypox: prevalence, diagnostics, and countermeasures. Clinical Infectious Diseases. 2005 Dec; 41(12): 1765-71. doi: 10.1086/498155. DOI: https://doi.org/10.1086/498155

Gong Q, Wang C, Chuai X, Chiu S. Monkeypox virus: a re-emergent threat to humans. Virologica Sinica. 2022 Jul. doi: 10.1016/j.virs.2022.07.006. DOI: https://doi.org/10.1016/j.virs.2022.07.006

Thornhill JP, Barkati S, Walmsley S, Rockstroh J, Antinori A, Harrison LB, Palich R, Nori A, Reeves I, Habibi MS, Apea V. Monkeypox virus infection in humans across 16 countries—April–June 2022. New England Journal of Medicine. 2022 Aug; 387(8): 679-91. doi: 10.1056/NEJMoa2207323. DOI: https://doi.org/10.1056/NEJMoa2207323

Naji H. Monkeypox virus: Transmission, signs and symptoms, prevention, and epidemiology. European Journal of Medical and Health Sciences. 2022 Oct; 4(5): 30-4. doi: 10.24018/ejmed.2022.4.5.1422. DOI: https://doi.org/10.24018/ejmed.2022.4.5.1422

Sklenovská N. Monkeypox virus. InAnimal-origin viral zoonoses. Singapore: Springer; 2020. doi: 10.1007/978-981-15-2651-0_2. DOI: https://doi.org/10.1007/978-981-15-2651-0_2

Reynolds MG, Yorita KL, Kuehnert MJ, Davidson WB, Huhn GD, Holman RC et al. Clinical manifestations of human monkeypox influenced by route of infection. The Journal of Infectious Diseases. 2006 Sep; 194(6): 773-80. doi: 10.1086/505880. DOI: https://doi.org/10.1086/505880

Cho CT and Wenner HA. Monkeypox virus. Bacteriological Reviews. 1973 Mar; 37(1): 1-8. doi: 10.1128/br.37.1.1-18.1973. DOI: https://doi.org/10.1128/br.37.1.1-18.1973

Altindis M, Puca E, Shapo L. Diagnosis of monkeypox virus–An overview. Travel Medicine and Infectious Disease. 2022 Sep: 102459. doi: 10.1016/j.tmaid.2022.102459. DOI: https://doi.org/10.1016/j.tmaid.2022.102459

Alakunle E, Moens U, Nchinda G, Okeke MI. Monkeypox virus in Nigeria: Infection biology, Epidemiology, and Evolution. Viruses. 2020 Nov; 12(11): 1257. doi: 10.3390/v12111257. DOI: https://doi.org/10.3390/v12111257

Shchelkunov SN, Totmenin AV, Safronov PF, Mikheev MV, Gutorov VV, Ryazankina OI et al. Analysis of the monkeypox virus genome. Virology. 2002 Jun; 297(2): 172-94. doi: 10.1006/viro.2002.1446. DOI: https://doi.org/10.1006/viro.2002.1446

Farahat RA, Ali I, Tareq AA, Benmelouka AY, Albakri K, El-Sakka AA et al. Monkeypox and human transmission: Are we on the verge of another pandemic? Travel Medicine and Infectious Disease. 2022 Sep; 49: 102387. doi: 10.1016/j.tmaid.2022.102387. DOI: https://doi.org/10.1016/j.tmaid.2022.102387

Chakraborty S, Chandran D, Mohapatra RK, Yatoo MI, Islam A, Sharma AK et al. Marburg virus disease–a mini-review. Journal Experimental Biology and Agricultural Sciences. 2022 Oct;10(2320): 689-96. doi: 10.18006/2022.10(4).689.696. DOI: https://doi.org/10.18006/2022.10(4).689.696

Islam MR, Akash S, Rahman MM, Sharma R. Epidemiology, pathophysiology, transmission, genomic structure, treatment, and future perspectives of the novel marburg virus outbreak. International Journal of Surgery. 2023 Jan; 109(1): 36-8. doi: 10.1097/JS9.0000000000000096. DOI: https://doi.org/10.1097/JS9.0000000000000096

Nakayama E and Saijo M. Animal models for Ebola and Marburg virus infections. Frontiers in Microbiology. 2013 Sep; 4: 267. doi: 10.3389/fmicb.2013.00267. DOI: https://doi.org/10.3389/fmicb.2013.00267

Cooper TK, Sword J, Johnson JC, Bonilla A, Hart R, Liu DX et al. new insights into Marburg virus disease pathogenesis in the rhesus macaque model. The Journal of Infectious Diseases. 2018 Nov; 218(suppl_5): S423-33. doi: 10.1093/infdis/jiy367. DOI: https://doi.org/10.1093/infdis/jiy367

Ewers EC, Pratt WD, Twenhafel NA, Shamblin J, Donnelly G, Esham H et al. Natural history of aerosol exposure with Marburg virus in rhesus macaques. Viruses. 2016 Mar; 8(4): 87. doi: 10.3390/v8040087. DOI: https://doi.org/10.3390/v8040087

Rizk JG, Lippi G, Henry BM, Forthal DN, Rizk Y. Prevention and treatment of monkeypox. Drugs. 2022 Jun; 82(9): 957-63. doi: 10.1007/s40265-022-01742-y. DOI: https://doi.org/10.1007/s40265-022-01742-y

Sherwat A, Brooks JT, Birnkrant D, Kim P. Tecovirimat and the treatment of monkeypox—past, present, and future considerations. New England Journal of Medicine. 2022 Aug 18; 387(7): 579-81. doi: 10.1056/NEJMp2210125. DOI: https://doi.org/10.1056/NEJMp2210125

Sudarmaji N, Kifli N, Hermansyah A, Yeoh SF, Goh BH, Ming LC. Prevention and treatment of monkeypox: a systematic review of preclinical studies. Viruses. 2022 Nov; 14(11): 2496. doi: 10.3390/v14112496. DOI: https://doi.org/10.3390/v14112496

Shamim MA, Padhi BK, Satapathy P, Veeramachaneni SD, Chatterjee C, Tripathy S et al. The use of antivirals in the treatment of human monkeypox outbreaks: a systematic review. International Journal of Infectious Diseases. 2023 Feb; 127: 150-61. doi: 10.1016/j.ijid.2022.11.040. DOI: https://doi.org/10.1016/j.ijid.2022.11.040

Ortiz-Saavedra B, León-Figueroa DA, Montes-Madariaga ES, Ricardo-Martínez A, Alva N, Cabanillas-Ramirez C et al. Antiviral treatment against monkeypox: a scoping review. Tropical Medicine and Infectious Disease. 2022 Nov; 7(11): 369. doi: 10.3390/tropicalmed7110369. DOI: https://doi.org/10.3390/tropicalmed7110369

Desai AN, Thompson GR, Neumeister SM, Arutyunova AM, Trigg K, Cohen SH. Compassionate use of tecovirimat for the treatment of monkeypox infection. Journal of the American Medical Association. 2022 Oct; 328(13): 1348-50. doi: 10.1001/jama.2022.15336. DOI: https://doi.org/10.1001/jama.2022.15336

O’Laughlin K, Tobolowsky FA, Elmor R, Overton R, O’Connor SM, Damon IK et al. Clinical use of tecovirimat (Tpoxx) for treatment of monkeypox under an investigational new drug protocol—United States, May–August 2022. Morbidity and Mortality Weekly Report. 2022 Sep; 71(37): 1190. doi: 10.15585/mmwr.mm7137e1. DOI: https://doi.org/10.15585/mmwr.mm7137e1

Soheili M and Nasseri S. Monkeypox: virology, pathophysiology, clinical characteristics, epidemiology, vaccines, diagnosis, and treatments. Journal of Pharmacy and Pharmaceutical Sciences. 2022 Sep; 25(25): 322-297. doi: 10.18433/jpps33138. DOI: https://doi.org/10.18433/jpps33138

Shrestha AB, Mehta A, Zahid MJ, Candelario K, Shrestha S, Pokharel P. Concerns over cardiovascular manifestations associated with monkeypox immunization: a literature review. Annals of Medicine and Surgery. 2023 Jun; 85(6): 2797. doi: 10.1097/MS9.0000000000000861. DOI: https://doi.org/10.1097/MS9.0000000000000861

Zaeck LM, Lamers MM, Verstrepen BE, Bestebroer TM, van Royen ME, Götz H et al. Low levels of monkeypox virus-neutralizing antibodies after MVA-BN vaccination in healthy individuals. Nature Medicine. 2023 Jan; 29(1): 270-8. doi: 10.1038/s41591-022-02090-w. DOI: https://doi.org/10.1038/s41591-022-02090-w

Hatch GJ, Graham VA, Bewley KR, Tree JA, Dennis M, Taylor I et al. Assessment of the protective effect of Imvamune and Acam2000 vaccines against aerosolized monkeypox virus in cynomolgus macaques. Journal of Virology. 2013 Jul; 87(14): 7805-15. doi: 10.1128/JVI.03481-12. DOI: https://doi.org/10.1128/JVI.03481-12

Peter OJ, Madubueze CE, Ojo MM, Oguntolu FA, Ayoola TA. Modeling and optimal control of monkeypox with cost-effective strategies. Modeling Earth Systems and Environment. 2023 Jun; 9(2): 1989-2007. doi: 10.1007/s40808-022-01607-z. DOI: https://doi.org/10.1007/s40808-022-01607-z

Guarner J, Del Rio C, Malani PN. Monkeypox in 2022—what clinicians need to know. Journal of the American Medical Association. 2022 Jul; 328(2): 139-40. doi: 10.1001/jama.2022.10802. DOI: https://doi.org/10.1001/jama.2022.10802