Innovative Therapeutic Paradigms in Diabetes Mellitus: Current Progress and Future Directions: Novel Therapeutic Paradigms in Diabetes Management

Amna Sattar

doi:10.54393/pbmj.v9i1.1325

Authors

Amna Sattar Department of Medicine, Jining Medical University, China

DOI:

https://doi.org/10.54393/pbmj.v9i1.1325

Keywords:

Diabetes Mellitus, Nanotechnology, Intestinal Microbiota, Insulin

Abstract

Diabetes mellitus is a chronic metabolic disease that is marked by inadequate glucose control that leads to eventual complications in the cardiovascular, renal, neurological, and ocular systems. The conventional approaches to treatment, such as insulin injections, oral hypoglycemic drugs, and structured lifestyle changes, continue to be the predominant approaches to treatment. However, the techniques are commonly limited so as to contain the symptoms and not achieve a long-lasting remission or to cure the causes of the disease. This has altered the field of science in the recent past, where creative approaches towards treatment have been given focus to change or even reverse the stages of disease. Stem cell interventions have the potential to cure pancreatic β-cells, and genetic therapy is meant to fix the genetic defects that lead to the disease. Immunotherapy transplantation is being undertaken to protect the β-cells in diabetes type 1 diabetes, and nanotechnology and smart insulin delivery systems can provide more precise glycemic control. In addition, the intestinal microbiota modulation has also become one of the promising adjunctive mechanisms. This review gives these new methodologies, the current status of these methodologies, and the possibilities of these methodologies in the management of diabetes.

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