Transethosomes: A Breakthrough System for Transdermal and Topical Drug Delivery: Transethosomes for Transdermal and Topical Drug Delivery

Jawad  Ali; Reesha  Raza; Sibgha  Ameen; Anam  Arshad; Fauzia Karim; Muhammad  Waseem Akram; Lubna  Shakir

doi:10.54393/pbmj.v5i7.578

Authors

Jawad Ali Faculty of Pharmacy, Hajvery University Lahore, Pakistan
Reesha Raza Faculty of Pharmacy, Hajvery University Lahore, Pakistan
Sibgha Ameen Faculty of Pharmacy, Hajvery University Lahore, Pakistan
Anam Arshad Faculty of Pharmacy, Hajvery University Lahore, Pakistan
Fauzia Karim Faculty of Pharmacy, Hajvery University Lahore, Pakistan
Muhammad Waseem Akram Faculty of Pharmacy, Hajvery University Lahore, Pakistan
Lubna Shakir Faculty of Pharmacy, Hajvery University Lahore, Pakistan

DOI:

https://doi.org/10.54393/pbmj.v5i7.578

Keywords:

Nanotechnology, transethosomes, lipid-based delivery system, stratum corneum, liposomes, deformable

Abstract

The major hindrance in transdermal delivery of drugs is complex barrier of stratum corneum. New generations lipid based nano-system, particularly transethosomes have ability to permeate from rigid network of stratum corneum. They have proved to be a promising tool for the transport of drugs. This article reviews these ethanol-based, elastic, and deformable vesicles. The major components that provide the vesicles their distinct properties are phospholipids, ethanol, edge activator, and water. Ethanol imparts softness and edge activator increases the permeation by providing elasticity, making it possible to deliver drug molecules in blood. It is a non-invasive technique that can be used as a carrier for NSAID, anticancer, antifungal, and antihypertensive, among other drugs.

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