Prevalence of Parkinson’s disease in Pakistan – A Systematic Review

Prevalence of Parkinson’s Disease in Pakistan

Authors

  • Yasir Akbar Jamali Department of Physiology, University of Sindh, Jamshoro, Pakistan
  • Hajira Naila Rahu Department of Physiology, People’s University of Medical and Health Sciences (Women), Nawabshah, Pakistan
  • Ashoke Kumar Institute of Physiotherapy Rehabilitation Sciences, Liaquat University of Medical & Health Sciences, Jamshoro, Pakistan
  • Ali Bux Khuhro Institute of Microbiology, Shah Abdul Latif University, Khairpur, Pakistan
  • Abdul Sami Shaikh Department of Pharmacy, Shah Abdul Latif University, Khairpur, Pakistan
  • Sanam Soomro Department of Community Medicine, Peoples University of Medical and Health Sciences (Women), Nawabshah, Pakistan

DOI:

https://doi.org/10.54393/pbmj.v7i01.1027

Keywords:

Parkinson’s Disease, Epidemiology, Parkinsonism

Abstract

Numerous epidemiological investigations pertaining to Parkinson's disease (PD) have been carried out on a global scale during the course of time. While each research documented an increase in the frequency and incidence rate of PD as individuals age, there were variations in the overall estimations seen across various nations. Objective: The purpose of this study is to provide a thorough analysis of PD incidence and prevalence rates in Pakistan. Methods: Google Scholar, Medline, and Embase were used to look for studies which reported the incidence of PD around the world. The searches were limited to English-language studies about people that happened between 1965 to 2023. Results: A total of 7 studies were conducted on Parkinson’s disease in Pakistan. Muhammad Tufail et al. in a cross-sectional study observed a heightened prevalence of Parkinson's disease, with 600 patients identified in Khyber Pakhtunkhwa (KPK). In a cross-sectional study conducted in Lahore, 85 cases of PD were identified within a hospital setting. Fifty cases in a cross-sectional study were conducted at a Hospital in Rawalpindi. Saira et al. performed an observational study at Islamabad Hospital and found the prevalence of We estimated the overall frequency of PD in Pakistan was 1016 cases in this systematic review. Males were more diagnosed with PD as compared to females. Conclusions: The data from the studies reviewed here indicate that PD increased in Pakistan during the last decade. While males were dominant in this study which is not different from across the globe. 

References

Marsden CD. Movement disorders. In: Weatherall DJ, Ledingham JGG, Warrell DA, editors. In: Oxford textbook of medicine. New York: Oxford Universitv Press In. 1996: 3998–4022.

Balestrino R, Schapira AH. Parkinson disease. European Journal of Neurology. 2020 Jan; 27(1): 27-42. doi: 10.1111/ene.14108. DOI: https://doi.org/10.1111/ene.14108

Ascherio A, Schwarzschild MA. The epidemiology of Parkinson's disease: risk factors and prevention. The Lancet Neurology. 2016 Nov; 15(12): 1257-72. doi:10.1016/S1474-4422(16)30230-7. DOI: https://doi.org/10.1016/S1474-4422(16)30230-7

Simon DK, Tanner CM, Brundin P. Parkinson disease epidemiology, pathology, genetics, and pathophysiology. Clinics In Geriatric Medicine. 2020 Feb; 36(1): 1-2. doi: 10.1016/j.cger.2019.08.002. DOI: https://doi.org/10.1016/j.cger.2019.08.002

González-Casacuberta I, Juárez-Flores DL, Morén C, Garrabou G. Bioenergetics and autophagic imbalance in patients-derived cell models of parkinson disease supports systemic dysfunction in neurodegeneration. Frontiers in Neuroscience. 2019 Sep; 13: 894. doi: 10.3389/fnins.2019.00894. DOI: https://doi.org/10.3389/fnins.2019.00894

Pohl C, Dikic I. Cellular quality control by the ubiquitin-proteasome system and autophagy. Science. 2019 Nov; 366(6467): 818-22. doi: 10.1126/science.aax3769. DOI: https://doi.org/10.1126/science.aax3769

Feigin VL, Nichols E, Alam T, Bannick MS, Beghi E, Blake N, et al. Global, regional, and national burden of neurological disorders, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016. The Lancet Neurology. 2019 May; 18(5): 459-80.

Dorsey E, Sherer T, Okun MS, Bloem BR. The emerging evidence of the Parkinson pandemic. Journal of Parkinson's Disease. 2018 Jan; 8(s1): S3-8. doi: 10.3233/JPD-181474. DOI: https://doi.org/10.3233/JPD-181474

Deuschl G, Beghi E, Fazekas F, Varga T, Christoforidi KA, Sipido E, et al. The burden of neurological diseases in Europe: an analysis for the Global Burden of Disease Study 2017. The Lancet Public Health. 2020 Oct; 5(10): e551-67. doi: 10.1016/S2468-2667(20)30190-0. DOI: https://doi.org/10.1016/S2468-2667(20)30190-0

Boina R. Assessing the Increasing Rate of Parkinson’s Disease in the US and its Prevention Techniques. International Journal of Biotechnology. 2022 Jan; 3(1): 1-18.

Tufail M. Clinical features and risk factors of Parkinson’s disease in a population of Khyber Pakhtunkhwa, Pakistan: a case-control study. Neurodegenerative Diseases. 2020 Jun; 19(5-6): 211-7. doi: 10.1159/000506742. DOI: https://doi.org/10.1159/000506742

Mukhtar S, Imran R, Zaheer M, Tariq H. Frequency of non-motor symptoms in Parkinson’s disease presenting to tertiary care centre in Pakistan: an observational, cross-sectional study. BMJ Open. 2018 May; 8(5): e019172. doi: 10.1136/bmjopen-2017-019172. DOI: https://doi.org/10.1136/bmjopen-2017-019172

Imtiaz N, Mehreen S, Saeed K, Akhtar N, Ur H, Rehman SA, et al. Study of prevalence of Parkinson’s disease in elderly population in Rawalpindi, Pakistan. Pakistan. J. Entomol. Zool Stud. 2016 Oct; 4(6):845-7.

Saad S, Nomani AZ, Badshah M, Afzal A. Frequency of non-motor symptoms in Parkinson disease: experience from Pakistan. Pakistan Journal of Neurological Sciences (PJNS). 2017 Dec; 12(1): 8-15.

Khealani BA, Baig SM. Clinical spectrum of Parkinson's disease from Pakistan. Singapore medical journal. 2006 Dec; 47(12): 1075-9.

Khan S, Nabi G, Naeem M, Ali L, Silburn PA, Mellick GD. A door-to-door survey to estimate the prevalence of Parkinsonism in Pakistan. Neuropsychiatric Disease and Treatment. 2016 Jun: 1499-506. doi: 10.2147/NDT.S86329. DOI: https://doi.org/10.2147/NDT.S86329

Moolchandani J, Moolchandani G, Turab SM, Iqbal N, Rehman A, Memon S. Frequency of Non-Motor Clinical Features of Parkinson Disease and the Associated Factors in Pakistan. Pakistan Journal of Zoology. 2022 May: 1-5. doi: 10.17582/journal.pjz/20220406050423. DOI: https://doi.org/10.17582/journal.pjz/20220406050423

Barbosa MT, Caramelli P, Maia DP, Cunningham MC, Guerra HL, Lima‐Costa MF, et al. Parkinson's disease in the elderly: A community‐based survey in Brazil (the Bambuí study). Movement Disorders. 2006 Jun; 21(6): 800-8. doi:10.1002/mds.20806. DOI: https://doi.org/10.1002/mds.20806

Benito‐León J, Bermejo‐Pareja F, Rodríguez J, Molina JA, Gabriel R, Morales JM. Neurological Disorders in Central Spain (NEDICES) Study Group. Prevalence of PD and other types of parkinsonism in three elderly populations of central Spain. Movement Disorders. 2003 Mar; 18(3): 267-74. doi:10.1002/mds.10362. DOI: https://doi.org/10.1002/mds.10362

Clavería LE, Duarte J, Sevillano MD, Pérez‐Sempere A, Cabezas C, Rodríguez F, et al. Prevalence of Parkinson's disease in Cantalejo, Spain: a door‐to‐door survey. Movement disorders: official journal of the Movement Disorder Society. 2002 Mar; 17(2): 242-9. doi:10.1002/mds.10087. DOI: https://doi.org/10.1002/mds.10087

Nicoletti A, Sofia V, Bartoloni A, Bartalesi F, Barahon HG, Giuffrida S, et al.Prevalence of Parkinson's disease: a door-to-door survey in rural Bolivia. Parkinsonism & Related Disorders. 2003 Oct; 10(1): 19-21. doi: 10.1016/S1353-8020(03)00066-X. DOI: https://doi.org/10.1016/S1353-8020(03)00066-X

De Rijk MC, Breteler MM, Graveland GA, Ott A, Grobbee DE, Van der Meche FG, et al. Prevalence of Parkinson's disease in the elderly: the Rotterdam Study. Neurology. 1995 Dec; 45(12): 2143-6. doi: 10.1212/WNL.45.12.2143. DOI: https://doi.org/10.1212/WNL.45.12.2143

Zhang ZX, Roman GC, Hong Z, Wu CB, Qu QM, Huang JB, et al. Parkinson's disease in China: prevalence in Beijing, Xian, and Shanghai. The Lancet. 2005 Feb; 365(9459): 595-7. doi: 10.1016/S0140-6736(05)70801-1. DOI: https://doi.org/10.1016/S0140-6736(05)70801-1

Twelves D, Perkins KS, Counsell C. Systematic review of incidence studies of Parkinson's disease. Movement disorders: Official Journal of The Movement Disorder Society. 2003 Jan; 18(1): 19-31. doi: 10.1002/mds.10305. DOI: https://doi.org/10.1002/mds.10305

Baldereschi M, Di Carlo A, Rocca WA, Vanni P, Maggi S, Perissinotto E, et al. Parkinson’s disease and parkinsonism in a longitudinal study: two-fold higher incidence in men. Neurology. 2000 Nov; 55(9): 1358-63. doi:10.1212/WNL.55.9.1358. DOI: https://doi.org/10.1212/WNL.55.9.1358

Granieri E, Carreras M, Casetta I, Govoni V, Tola MR, Paolino E, et al. Parkinson's disease in Ferrara, Italy, 1967 through 1987. Archives of Neurology. 1991 Aug; 48(8): 854-7. doi:10.1001/archneur.1991.00530200096026. DOI: https://doi.org/10.1001/archneur.1991.00530200096026

Georgiev D, Hamberg K, Hariz M, Forsgren L, Hariz GM. Gender differences in Parkinson's disease: a clinical perspective. Acta Neurologica Scandinavica. 2017 Dec; 136(6): 570-84. doi: 10.1111/ane.12796. DOI: https://doi.org/10.1111/ane.12796

Alves G, Müller B, Herlofson K, HogenEsch I, Telstad W, Aarsland D, et al. Incidence of Parkinson's disease in Norway. The Norwegian ParkWest study. Journal of Neurology, Neurosurgery & Psychiatry. 2009 Feb; 80(8): 851-7. doi: 10.1136/jnnp.2008.168211. DOI: https://doi.org/10.1136/jnnp.2008.168211

Linder J, Stenlund H, Forsgren L. Incidence of Parkinson's disease and parkinsonism in northern Sweden: a population‐based study. Movement Disorders. 2010 Feb; 25(3): 341-8. doi: 10.1002/mds.22987. DOI: https://doi.org/10.1002/mds.22987

Kovács M, Makkos A, Aschermann Z, Janszky J, Komoly S, Weintraut R, et al. Impact of sex on the nonmotor symptoms and the health-related quality of life in Parkinson’s disease. Parkinson’s Disease. 2016 May; 2016. doi:10.1155/2016/7951840. DOI: https://doi.org/10.1155/2016/7951840

Mayeux R, Marder K, Cote LJ, Denaro J, Hemenegildo N, Mejia H, et al. The frequency of idiopathic Parkinson's disease by age, ethnic group, and sex in northern Manhattan, 1988–1993. American journal of epidemiology. 1995 Oct; 142(8): 820-7. doi:10.1093/oxfordjournals.aje.a117721. DOI: https://doi.org/10.1093/oxfordjournals.aje.a117721

Wooten GF, Currie LJ, Bovbjerg VE, Lee JK, Patrie J. Are men at greater risk for Parkinson’s disease than women?. Journal of Neurology, Neurosurgery & Psychiatry. 2004 Apr; 75(4): 637-9. doi: 10.1136/jnnp.2003.020982. DOI: https://doi.org/10.1136/jnnp.2003.020982

Elbaz A, Bower JH, Maraganore DM, McDonnell SK, Peterson BJ, Ahlskog JE, et al. Risk tables for parkinsonism and Parkinson's disease. Journal of Clinical Epidemiology. 2002 Jan; 55(1): 25-31. doi: 10.1016/S0895-4356(01)00425-5. DOI: https://doi.org/10.1016/S0895-4356(01)00425-5

De Lau LM, Giesbergen PC, De Rijk MC, Hofman A, Koudstaal PJ, Breteler MM. Incidence of parkinsonism and Parkinson disease in a general population: the Rotterdam Study. Neurology. 2004 Oct; 63(7): 1240-4. doi: 10.1212/01.WNL.0000140706.52798.BE. DOI: https://doi.org/10.1212/01.WNL.0000140706.52798.BE

Van Den Eeden SK, Tanner CM, Bernstein AL, Fross RD, Leimpeter A, Bloch DA, et al. Incidence of Parkinson’s disease: variation by age, gender, and race/ethnicity. American journal of epidemiology. 2003 Jun; 157(11): 1015-22. doi: 10.1093/aje/kwg068. DOI: https://doi.org/10.1093/aje/kwg068

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Published

2024-01-31
CITATION
DOI: 10.54393/pbmj.v7i01.1027
Published: 2024-01-31

How to Cite

Jamali, Y. A., Rahu, H. N., Kumar, A., Khuhro, A. B., Shaikh, A. S., & Soomro, S. (2024). Prevalence of Parkinson’s disease in Pakistan – A Systematic Review : Prevalence of Parkinson’s Disease in Pakistan. Pakistan BioMedical Journal, 7(01), 60–65. https://doi.org/10.54393/pbmj.v7i01.1027

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