The Role of Propolis in Muscle Repair: A Systematic Review: Propolis in Muscle Repair

Putri Ragil Ayu; Sasanthy Kusumaningtyas; Dewi Sukmawati

doi:10.54393/pbmj.v8i1.1181

Authors

Putri Ragil Ayu Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia
Sasanthy Kusumaningtyas Department of Anatomy, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia
Dewi Sukmawati Department of Histology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia

DOI:

https://doi.org/10.54393/pbmj.v8i1.1181

Keywords:

Propolis, Muscle Repair, Antioxidant, Anti-Inflammatory

Abstract

Propolis a natural substance that comes from bees possesses various medicinal properties including. antioxidant, anti-inflammatory, and beneficial in the metabolic system. Muscle repair is crucial for maintaining muscle function, especially in cases of injury, oxidative stress, and ageing which cause muscle loss and dysfunction. Propolis has emerged as a potential alternative treatment for muscle repair. Objective: To investigate the impact of propolis on muscle repair. Methods: A systematic literature review was conducted using databases such as PubMed, Google Scholar, Research Gate, and Cochrane Library. The PRISMA guideline was followed for analysis. The approach uses keywords such as propolis, muscle, and skeletal muscle. Articles were selected based on sample characteristics, intervention, and muscle repair parameters. The searched keywords include propolis, muscle, and skeletal muscle. Evaluation parameters included oxidative stress markers, inflammation, molecular mechanisms, muscle capillaries, muscle mass, strength, and function. Results: The initial search uncovered 7676 articles, after further screening, it comprised a total of 23 studies that were included in the results. The collected articles summarized the main mechanism of action of propolis in muscle repair, primarily due to its antioxidant, and anti-inflammatory properties, and its effect on glucose metabolism, which influences muscle fatigue, strength, and mass. Conclusions: It was concluded that propolis as a bee’s natural product, has several advantages in muscle repair due to its multiple mechanisms of action, encompassing antioxidants, anti-inflammatory properties, impact on muscle glucose metabolism, and stimulation angiogenesis.

References

Ueda M, Hayashibara K, Ashida H. Propolis Extract Promotes Translocation of Glucose Transporter 4 and Glucose Uptake Through Both PI3K‐and AMPK‐Dependent Pathways in Skeletal Muscle. Bio-factors. 2013 Jul; 39(4): 457-66. doi: 10.1002/biof.1085. DOI: https://doi.org/10.1002/biof.1085

Torri F, Lopriore P, Montano V, Siciliano G, Mancuso M, Ricci G. Pathophysiology and Management of Fatigue in Neuromuscular Diseases. International Journal of Molecular Sciences. 2023 Mar; 24(5): 5005. doi: 10.3390/ijms24055005. DOI: https://doi.org/10.3390/ijms24055005

Okamura T, Hamaguchi M, Bamba R, Nakajima H, Yoshimura Y, Kimura T et al. Brazilian Green Propolis Improves Gut Microbiota Dysbiosis and Protects Against Sarcopenic Obesity. Journal of Cachexia, Sarcopenia and Muscle. 2022 Dec; 13(6): 3028-47. doi: 10.1002/jcsm.13076. DOI: https://doi.org/10.1002/jcsm.13076

Volpato S, Bianchi L, Lauretani F, Lauretani F, Bandinelli S, Guralnik JM et al. Role of Muscle Mass and Muscle Quality in the Association Between Diabetes and Gait Speed. Diabetes Care. 2012 Aug; 35(8): 1672-9.doi: 10.2337/dc11-2202. DOI: https://doi.org/10.2337/dc11-2202

Sizoo D, Stam SP, de Heide LJ, Emous M, van Zutphen T, van Dijk PR et al. The Association of Low Muscle Mass with Prevalence and Incidence of Type 2 Diabetes in Different BMI Classes. Diabetes Research and Clinical Practice. 2023 Jan; 195: 110197. doi: 10.1016/j.diabres.2022.110197. DOI: https://doi.org/10.1016/j.diabres.2022.110197

Wright VJ, Schwartzman JD, Itinoche R, Wittstein J. The Musculoskeletal Syndrome of Menopause. Climacteric. 2024 Sep; 27(5): 466-72. doi: 10.1080/13697137.2024.2380363. DOI: https://doi.org/10.1080/13697137.2024.2380363

Stožer A, Vodopivc P, Bombek LK. Pathophysiology of Exercise-Induced Muscle Damage and Its Structural, Functional, Metabolic, and Clinical Consequences. Physiological Research. 2020 Aug; 69(4): 565. doi: 10.33549/physiolres.934371. DOI: https://doi.org/10.33549/physiolres.934371

Wiedmer P, Jung T, Castro JP, Pomatto LC, Sun PY, Davies KJ et al. Sarcopenia–Molecular Mechanisms and Open Questions. Ageing Research Reviews. 2021 Jan; 65: 101200. doi: 10.1016/j.arr.2020.101200. DOI: https://doi.org/10.1016/j.arr.2020.101200

Buckinx F, Aubertin-Leheudre M. Sarcopenia in Menopausal Women: Current Perspectives. International Journal of Women's Health. 2022 Jun: 805-19. doi: 10.2147/IJWH.S340537. DOI: https://doi.org/10.2147/IJWH.S340537

Ciudin A, Simó-Servat A, Palmas F, Barahona MJ. Sarcopenic Obesity: A New Challenge in the Clinical Practice. Endocrinología, Diabetes y Nutrición (English ed.). 2020 Dec; 67(10): 672-81. doi: 10.1016/j.endien.2020.03.007. DOI: https://doi.org/10.1016/j.endien.2020.03.007

Wei S, Nguyen TT, Zhang Y, Ryu D, Gariani K. Sarcopenic Obesity: Epidemiology, Pathophysiology, Cardiovascular Disease, Mortality, and Management. Frontiers in Endocrinology. 2023 Jun; 14: 1185221. doi: 10.3389/fendo.2023.1185221. DOI: https://doi.org/10.3389/fendo.2023.1185221

Chinen N, Otsu W, Ohuchi K, Ando S, Nakamura S, Kono H et al. Brazilian Green Propolis Promotes the Cytoprotective Expression of Heme Oxygenase-1 Against Oxidative Stress Injury in Murine Myoblast Cells. Functional Foods in Health and Disease. 2020 Dec; 10(12): 493-504. doi: 10.31989/ffhd.v10i12.756. DOI: https://doi.org/10.31989/ffhd.v10i12.756

Stotz A, Hamacher D, Zech A. Relationship Between Muscle Strength and Gait Parameters in Healthy Older Women and Men. International Journal of Environmental Research and Public Health. 2023 Apr; 20(7): 5362. doi: 10.3390/ijerph20075362. DOI: https://doi.org/10.3390/ijerph20075362

Page MJ, McKenzie JE, Bossuyt PM, Boutron I, Hoffmann TC, Mulrow CD et al. The PRISMA 2020 Statement: An Updated Guideline for Reporting Systematic Reviews. British Medical Journal. 2021 Mar; 372. doi: 10.1136/bmj.n71. DOI: https://doi.org/10.1136/bmj.n71

Caperuto EC, Nicoletti MA, Silva MM, Cezar T, Goularte JO, Gusmão N et al. Effects of Artepelin-C Supplementation Present in Propolis Related to Inflammatory Processes in Physically Active Individuals. International Journal of Food and Nutrition Research. 2019; 3: 1-23.

Soleimani D, Miryan M, Hadi V, Gholizadeh Navashenaq J, Moludi J, Sayedi SM et al. Effect of Propolis Supplementation On Athletic Performance, Body Composition, Inflammation, and Oxidative Stress Following Intense Exercise: A Triple‐Blind Randomized Clinical Trial. Food Science and Nutrition. 2021 Jul; 9(7): 3631-40. doi: 10.1002/fsn3.2319. DOI: https://doi.org/10.1002/fsn3.2319

Tsuchiya Y, Hirata N, Asama T, Osakabe N, Hirata K, Akagi R. Can a Short-Term Daily Oral Administration of Propolis Improve Muscle Fatigue and Recovery? International Journal of Sports Medicine. 2022 Sep; 43(10): 859-64. doi: 10.1055/a-1808-6319. DOI: https://doi.org/10.1055/a-1808-6319

Kanazashi M, Iida T, Nakanishi R, Tanaka M, Ikeda H, Takamiya N et al. Brazilian Propolis Intake Decreases Body Fat Mass and Oxidative Stress in Community-Dwelling Elderly Females: A Randomized Placebo-Controlled Trial. Nutrients. 2023 Jan; 15(2): 364. doi: 10.3390/nu15020364. DOI: https://doi.org/10.3390/nu15020364

Moayedi F, Taghian F, Dehkordi KJ, Hosseini SA. Cumulative Effects of Exercise Training and Consumption of Propolis On Managing Diabetic Dyslipidemia in Adult Women: A Single-Blind, Randomized, Controlled Trial with Pre–Post-Intervention Assessments. The Journal of Physiological Sciences. 2023 Jan; 73(1): 17. doi: 10.1186/s12576-023-00872-6. DOI: https://doi.org/10.1186/s12576-023-00872-6

Tan-No K, Nakajima T, Shoji T, Nakagawasai O, Niijima F, Ishikawa M et al. Anti-Inflammatory Effect of Propolis Through Inhibition of Nitric Oxide Production On Carrageenin-Induced Mouse Paw Edema. Biological and Pharmaceutical Bulletin. 2006; 29(1): 96-9. doi: 10.1248/bpb.29.96. DOI: https://doi.org/10.1248/bpb.29.96

Ozyurt H, Ozyurt B, Koca K, Ozgocmen S. Caffeic Acid Phenethyl Ester (CAPE) Protects Rat Skeletal Muscle Against Ischemia–Reperfusion-Induced Oxidative Stress. Vascular Pharmacology. 2007 Aug; 47(2-3): 108-12. doi: 10.1016/j.vph.2007.04.008. DOI: https://doi.org/10.1016/j.vph.2007.04.008

Lee ES, Uhm KO, Lee YM, Han M, Lee M, Park JM et al. CAPE (Caffeic Acid Phenethyl Ester) Stimulates Glucose Uptake Through AMPK (AMP-Activated Protein Kinase) Activation in Skeletal Muscle Cells. Biochemical and Biophysical Research Communications. 2007 Oct; 361(4): 854-8. doi: 10.1016/j.bbrc.2007.07.068. DOI: https://doi.org/10.1016/j.bbrc.2007.07.068

Andrade-Silva AR, Ramalho FS, Ramalho LN, Saavedra-Lopes M, Jordão Jr AA, Vanucchi H et al. Effect of NFκB Inhibition By CAPE On Skeletal Muscle Ischemia-Reperfusion Injury. Journal of Surgical Research. 2009 May; 153(2): 254-62. doi: 10.1016/j.jss.2008.04.009. DOI: https://doi.org/10.1016/j.jss.2008.04.009

Kasai M, Fukumitsu H, Soumiya H, Furukawa S. Ethanol Extract of Chinese Propolis Facilitates Functional Recovery of Locomotor Activity After Spinal Cord Injury. Evidence‐Based Complementary and Alternative Medicine. 2011; 2011(1): 749627. doi: 10.1155/2011/749627. DOI: https://doi.org/10.1155/2011/749627

Shen YC, Yen JC, Liou KT. Ameliorative Effects of Caffeic Acid Phenethyl Ester On an Eccentric Exercise-Induced Skeletal Muscle Injury by Down-Regulating NF-Κb Mediated Inflammation. Pharmacology. 2013 May; 91(3-4): 219-28. doi: 10.1159/000348412. DOI: https://doi.org/10.1159/000348412

Kwon TD, Lee MW, Kim KH. The Effect of Exercise Training and Water Extract from Propolis Intake On the Antioxidant Enzymes Activity of Skeletal Muscle and Liver in Rat. Journal of Exercise Nutrition & Biochemistry. 2014 Mar; 18(1): 9. doi: 10.5717/jenb.2014.18.1.9. DOI: https://doi.org/10.5717/jenb.2014.18.1.9

Yüce S, Gökçe EC, Iskdemir A, Koç ER, Cemil DB, Gökçe A et al. An Experimental Comparison of the Effects of Propolis, Curcumin, and Methylprednisolone On Crush Injuries of the Sciatic Nerve. Annals of Plastic Surgery. 2015 Jun; 74(6): 684-92. doi: 10.1097/SAP.0000000000000026. DOI: https://doi.org/10.1097/SAP.0000000000000026

Washio K, Kobayashi M, Saito N, Amagasa M, Kitamura H. Propolis Ethanol Extract Stimulates Cytokine and Chemokine Production Through NF‐Κb Activation in C2C12 Myoblasts. Evidence‐Based Complementary and Alternative Medicine. 2015; 2015(1): 349751. doi: 10.1155/2015/349751. DOI: https://doi.org/10.1155/2015/349751

Roquetto AR, Monteiro NE, Moura CS, Toreti VC, de Pace F, Dos Santos A et al. Green Propolis Modulates Gut Microbiota, Reduces Endotoxemia and Expression of TLR4 Pathway in Mice Fed a High-Fat Diet. Food Research International. 2015 Oct; 76: 796-803. doi: 10.1016/j.foodres.2015.07.026. DOI: https://doi.org/10.1016/j.foodres.2015.07.026

Tanaka M, Kanazashi M, Maeshige N, Kondo H, Ishihara A, Fujino H. Protective Effects of Brazilian Propolis Supplementation On Capillary Regression in the Soleus Muscle of Hindlimb-Unloaded Rats. The Journal of Physiological Sciences. 2019 Mar; 69: 223-33. doi: 10.1007/s12576-018-0639-z. DOI: https://doi.org/10.1007/s12576-018-0639-z

Egawa T, Ohno Y, Yokoyama S, Yokokawa T, Tsuda S, Goto K et al. The Protective Effect of Brazilian Propolis Against Glycation Stress in Mouse Skeletal Muscle. Foods. 2019 Sep; 8(10): 439. doi: 10.3390/foods8100439. DOI: https://doi.org/10.3390/foods8100439

Nosratiyan M, Farjah GH, Karimipour M, Pourheidar B. The Effect of Propolis-Gum Arabic as A Novel Nerve Guidance Channel On Regeneration of Sciatic Nerve in Male Rats. Turk. Neurosurg. 2021 Jan; 31: 361-7. doi: 10.5137/1019-5149.JTN.29813-20.2. DOI: https://doi.org/10.5137/1019-5149.JTN.29813-20.2

Tian S, Zhao H, Guo H, Feng W, Jiang C, Jiang Y. Propolis Ethanolic Extract Attenuates D-Gal-Induced C2C12 Cell Injury by Modulating Nrf2/HO-1 and P38/P53 Signaling Pathways. International Journal of Molecular Sciences. 2023 Mar; 24(7): 6408. doi: 10.3390/ijms24076408. DOI: https://doi.org/10.3390/ijms24076408

Tian S, Zhao H, Liu J, Ma X, Zheng L, Guo H, Jiang Y. Metabolomics Reveals That Alcohol Extract of Propolis Alleviates D-Gal-Induced Skeletal Muscle Senescence in Mice. Food Bioscience. 2022 Oct; 49: 101885. doi: 10.1016/j.fbio.2022.101885. DOI: https://doi.org/10.1016/j.fbio.2022.101885

Kiziltas H and Erkan C. The Effects of Different Beehives On Propolis Production and Quality. Food Science and Technology. 2020 Sep; 41: 877-83. doi: 10.1590/fst.20120. DOI: https://doi.org/10.1590/fst.20120

Cassina López BG, Bataglion GA, Jara JL, Pacheco Filho EF, de Mendonça Melo LS, Cardoso JC et al. Variation of the Phytoestrogen Composition of Red Propolis Throughout the Year. Journal of Apicultural Research. 2020 Aug; 59(4): 406-12. doi: 10.1080/00218839.2020.1714192. DOI: https://doi.org/10.1080/00218839.2020.1714192