Wound Healing Efficacy of Hondy, Aloe Vera, and Turmeric

Wound Healing Efficacy of Hondy, Aloe Vera, and Turmeric

Authors

  • Muhammad Jamil PARC Arid Zone Research Centre, Dera Ismail Khan, Pakistan
  • Muhammad Kashif Department of Clinical Sciences, Sub Campus Jhang, University of veterinary and Animal Sciences, Lahore, Pakistan
  • Bashir Ahmad Department of Plant Protection,University of Agriculture, Peshawar, Pakistan
  • Bibi Sadia Sardar Bahadur Khan Women's University, Quetta, Pakistan
  • Imtiaz Khan PARC Adaptive Research Cum Demonstration Institute, Miranshah, Pakistan
  • Imran Qazi PARC Adaptive Research Cum Demonstration Institute, Wana, Pakistan
  • Muhammad Fahimullah Khan Faculty of Veterinary and Animal Sciences, Gomal University, Dera Ismail Khan, Pakistan
  • Mubarik Ali Animal science Institute, National Agricultural Research Center, Islamabad, Pakistan
  • Muhammad Rasheed Animal science Institute, National Agricultural Research Center, -Islamabad, Pakistan
  • Muhammad Rehan Arif Institute of Food and Nutritional Sciences, Pir Mehr Ali Shah Arid Agriculture University Rawalpindi

DOI:

https://doi.org/10.54393/pbmj.v4i2.141

Abstract

Skin naturally acts as a body's protective layer and external environmental factors that can harm internal body organs are protected by it.So, maintaining skin integrity is vital for normal physiological functioning.In our daily lives, the bodies of both animals and humans are subjected to various forms of violence, some of which are severe enough to destroy the skin's continuity.A wound is a breakdown in the continuity of the skin. When the skin's continuity is disrupted, the body's interior organs are exposed.There's a risk of death in this case.There's a risk of death in this case. The skin's immediate response to a wound is the first step in the healing process, which begins automatically after the injury has been inflicted.It is possible to speed up this process in a variety of ways, including keeping the wound free of bacterial infection, moisture, and dirt.A number of antiseptic dressings are available for this purpose, and when applied topically,they help to speed up the healing process of wounds.They protect the wound from contamination by microorganisms and speed up the healing process.Among these are Aloe vera, honey, and turmeric, all of which have considerable wound healing capabilities.Turmeric, honey, and Aloe vera are all considered good for promoting wound healing.They are involved in the prevention of platelet aggregation, myocardial infarction, tumour formation, inflammatory cytokine release, oxidative stress, and metastasis.Several studies have demonstrated that they play a critical function in the promotion of wound healing. Their use for wound dressing has proven to be a successful method. The primary goal of this review is to summarise previous scientists' findings with authentic concluding verse for the use of Aloe vera,Turmeric and Honey that are safe, readily available, and less expensive.

References

Mustoe T (2004). Understanding chronic wounds: a unifying hypothesis on their pathogenesis and implications for therapy. The American Journal of Surgery,187(5): 65-70. https://doi.org/10.1016/S0002-9610(03)00306-4

Janis JE, Kwon RK, Lalonde DH (2010). A practical guide to wound healing. Plastic and reconstructive surgery, 125(6):230e-44e. 10.1097/PRS.0b013e3181d9a0d1

Stadelmann WK, Digenis AG, Tobin GR (1998). Physiology and healing dynamics of chronic cutaneous wounds. The American Journal of Surgery, 176(2):26S-38S. https://doi.org/10.1016/S0002-9610(98)00183-4

Robson MC, Heggers JP (1970). Delayed wound closures based on bacterial counts. Journal of surgical oncology, 2(4):379-83.

Robson MC (1997). Wound infection: a failure of wound healing caused by an imbalance of bacteria. Surgical Clinics of North America, 77(3):637-50. https://doi.org/10.1016/S0039-6109(05)70572-7

Jull AB, Cullum N, Dumville JC, Westby MJ, Deshpande S, Walker N (2015). Honey as a topical treatment for wounds. Cochrane Database of Systematic Reviews, (3). https://doi.org/10.1002/14651858.CD005083.pub4

Wasiak J, Cleland H, Campbell F, Spinks A (2013). Dressings for superficial and partial thickness burns. Cochrane Database of Systematic Reviews, (3). https://doi.org/10.1002/14651858.CD002106.pub4

O'Meara S, Al‐Kurdi D, Ologun Y, Ovington LG, Martyn‐St James M, Richardson R (2014). Antibiotics and antiseptics for venous leg ulcers. Cochrane Database of Systematic Reviews, (1). https://doi.org/10.1002/14651858.CD003557.pub5

Nelson EA, Bradley MD (2007). Dressings and topical agents for arterial leg ulcers. Cochrane database of systematic Reviews, (1). https://doi.org/10.1002/14651858.CD001836.pub2

French VM, Cooper RA, Molan PC (2005). The antibacterial activity of honey against coagulase-negative staphylococci. Journal of Antimicrobial Chemotherapy, 56(1):228-31.https://doi.org/10.1093/jac/dki193

Simon A, Traynor K, Santos K, Blaser G, Bode U, Molan P (2009). Medical honey for wound care—still the ‘latest resort’?.Evidence-based complementary and alternative medicine, 6(2):165-73. https://doi.org/10.1093/ecam/nem175

Lee DS, Sinno S, Khachemoune A (2011). Honey and wound healing. American journal of clinical dermatology, 12(3):181-90. https://doi.org/10.2165/11538930-000000000-00000

Allen KL, Molan PC, Reid GM (1991). A survey of the antibacterial activity of some New Zealand honeys. Journal of pharmacy and pharmacology, 43(12):817-22. https://doi.org/10.1111/j.2042-7158.1991.tb03186.x

Lusby PE, Coombes AL, Wilkinson JM (2005). Bactericidal activity of different honeys against pathogenic bacteria. Archives of medical research, 36(5):464-7. https://doi.org/10.1016/j.arcmed.2005.03.038

Cooper RA, Halas E, Molan PC (2002). The efficacy of honey in inhibiting strains of Pseudomonas aeruginosa from infected burns. The Journal of burn care & rehabilitation, 23(6):366-70. https://doi.org/10.1097/00004630-200211000-00002

Cooper RA, Molan PC, Harding KG (2002). The sensitivity to honey of Gram‐positive cocci of clinical significance isolated from wounds. Journal of applied microbiology, 93(5):857-63.

Sherlock O, Dolan A, Athman R, Power A, Gethin G, Cowman S, Humphreys H (2010). Comparison of the antimicrobial activity of Ulmo honey from Chile and Manuka honey against methicillin-resistant Staphylococcus aureus, Escherichia coli and Pseudomonas aeruginosa. BMC complementary and alternative medicine, 10(1):1-5. https://doi.org/10.1186/1472-6882-10-47

Irish J, Carter DA, Shokohi T, Blair SE (2006). Honey has an antifungal effect against Candida species. Medical Mycology, 44(3):289-91. https://doi.org/10.1080/13693780500417037

Oryan A, Zaker SR (1998). Effects of topical application of honey on cutaneous wound healing in rabbits. Journal of Veterinary Medicine Series, 45(1‐10):181-8.

Bergman A, Yanai J, Weiss J, Bell D, David MP (1983). Acceleration of wound healing by topical application of honey: an animal model. The American journal of surgery, 145(3):374-6. https://doi.org/10.1016/0002-9610(83)90204-0

Efem SE (1988). Clinical observations on the wound healing properties of honey. British journal of Surgery, 75(7):679-81.

Molan PC. Re-introducing honey in the management of wounds and ulcers-theory and practice. https://hdl.handle.net/10289/203

Subrahmanyam M (1993). Honey impregnated gauze versus polyurethane film (OpSiteR) in the treatment of burns—a prospective randomised study. British journal of plastic surgery, 46(4):322-3. https://doi.org/10.1016/0007-1226(93)90012-Z

Subrahmanyam M (1991). Topical application of honey in treatment of burns. Journal of British Surgery, 78(4):497-8. https://doi.org/10.1002/bjs.1800780435

Subrahmanyam M (1998). A prospective randomized clinical and histological study of superficial burn wound healing with honey and silver sulfadiazine. Burns, 24(2):157-61. https://doi.org/10.1016/S0305-4179(97)00113-7

Saber A (2010). Effect of honey versus intergel in intraperitoneal adhesion prevention and colonic anastomotic healing: a randomized controlled study in rats. International Journal of Surgery, 8(2):121-7. https://doi.org/10.1016/j.ijsu.2009.11.010

Biswal BM, Zakaria A, Ahmad NM (2003). Topical application of honey in the management of radiation mucositis. A preliminary study. Supportive Care in Cancer, 11(4):242-8. https://doi.org/10.1007/s00520-003-0443-y

Motallebnejad M, Akram S, Moghadamnia A, Moulana Z, Omidi S (2008). The effect of topical application of pure honey on radiation-induced mucositis: a randomized clinical trial. J contemp dent pract, 9(3):40-7.

Khanal B, Baliga M, Uppal N (2010). Effect of topical honey on limitation of radiation-induced oral mucositis: an intervention study. International journal of oral and maxillofacial surgery, 39(12):1181-5. https://doi.org/10.1016/j.ijom.2010.05.014

Rashad UM, Al-Gezawy SM, El-Gezawy E, Azzaz AN (2009). Honey as topical prophylaxis against radiochemotherapy-induced mucositis in head and neck cancer. The Journal of Laryngology & Otology, 123(2):223-8. https://doi.org/10.1017/S0022215108002478

Ingle R, Levin J, Polinder K (2006). Wound healing with honey-a randomised controlled trial. South African Medical Journal, 96(9):831-5.

McIntosh CD, Thomson CE (2006). Honey dressing versus paraffin tulle gras following toenail surgery. Journal of wound care, 15(3):133-6. https://doi.org/10.12968/jowc.2006.15.3.26877

Marshall C, Queen J, Manjooran J (2005). Honey vspovidone iodine following toenail surgery. WOUNDS UK, 1(1):10.

Mashhood AA, Khan TA, Sami AN (2006). Honey compared with 1% silver sulfadiazine cream in the treatment of superficial and partial thickness burns. Journal of Pakistan Association of Dermatologists, 16(1):14-9.

Bangroo AK, Khatri R, Chauhan S (2005). Honey dressing in pediatric burns. Journal of Indian Association of Pediatric Surgeons, 10(3):172. 10.4103/0971-9261.16970

Subrahmanyam M, Sahapure A, Nagane N. Effects of topical application of honey on burn wound healing.

Subrahmanyam M (1996). Honey dressing versus boiled potato peel in the treatment of burns: a prospective randomized study. Burns, 22(6):491-3. https://doi.org/10.1016/0305-4179(96)00007-1

Subrahmanyam M (1994). Honey-impregnated gauze versus amniotic membrane in the treatment of burns. Burns, 20(4):331-3. https://doi.org/10.1016/0305-4179(94)90061-2

Wijesinghe M, Weatherall M, Perrin K, Beasley R (2009). Honey in the treatment of burns: a systematic review and meta-analysis of its efficacy. Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet]

Moore OA, Smith LA, Campbell F, Seers K, McQuay HJ, Moore RA (2001). Systematic review of the use of honey as a wound dressing. BMC complementary and alternative medicine, 1(1):1-6. https://doi.org/10.1186/1472-6882-1-2

Subrahmanyam M (1999). Early tangential excision and skin grafting of moderate burns is superior to honey dressing: a prospective randomised trial. Burns, 25(8):729-31. https://doi.org/10.1016/S0305-4179(99)00063-7

Jull A, Walker N, Parag V, Molan P, Rodgers A (2008). Randomized clinical trial of honey-impregnated dressings for venous leg ulcers. Journal of British Surgery, 95(2):175-82. https://doi.org/10.1002/bjs.6059

Baruah A, Bordoloi M, Baruah HP (2016). Aloe vera: A multipurpose industrial crop. Industrial Crops and Products, 94:951-63. https://doi.org/10.1016/j.indcrop.2016.08.034

Pothuraju R, Sharma RK, Onteru SK, Singh S, Hussain SA (2016). Hypoglycemic and hypolipidemic effects of Aloe vera extract preparations: A review. Phytotherapy research, 30(2):200-7.

Singab AN, El‐Hefnawy HM, Esmat A, Gad HA, Nazeam JA (2015). A systemic review on aloe arborescens pharmacological profile: biological activities and pilot clinical trials. Phytotherapy Research, 29(12):1858-67.

Kumar R, Singh AK, Gupta A, Bishayee A, Pandey AK (2019). Therapeutic potential of Aloe vera-A miracle gift of nature. Phytomedicine, 60:152996. https://doi.org/10.1016/j.phymed.2019.152996

Kang MC, Kim SY, Kim YT, Kim EA, Lee SH, Ko SC, Wijesinghe WA, Samarakoon KW, Kim YS, Cho JH, Jang HS (2014). In vitro and in vivo antioxidant activities of polysaccharide purified from aloe vera (Aloe barbadensis) gel. Carbohydrate polymers, 99:365-71. https://doi.org/10.1016/j.carbpol.2013.07.091

Sánchez M, González-Burgos E, Iglesias I, Gómez-Serranillos MP (2020). Pharmacological update properties of Aloe vera and its major active constituents. Molecules, 25(6):1324. https://doi.org/10.3390/molecules25061324

Shakib Z, Shahraki N, Razavi BM, Hosseinzadeh H (2019). Aloe vera as an herbal medicine in the treatment of metabolic syndrome: A review. Phytotherapy Research, 33(10):2649-60.

Miroddi M, Navarra M, Calapai F, Mancari F, Giofrè SV, Gangemi S, Calapai G (2015). Review of clinical pharmacology of Aloe vera L. in the treatment of psoriasis. Phytotherapy Research, 29(5):648-55.

Gao Y, Kuok KI, Jin Y, Wang R (2019). Biomedical applications of Aloe vera. Critical reviews in food science and nutrition, 59(1): 244-56. https://doi.org/10.1080/10408398.2018.1496320

Akaberi M, Sobhani Z, Javadi B, Sahebkar A, Emami SA (2016). Therapeutic effects of Aloe spp. in traditional and modern medicine: A review. Biomedicine & Pharmacotherapy, 84:759-72. https://doi.org/10.1016/j.biopha.2016.09.096

Yang MS, Yu CP, Huang CY, Chao PD, Lin SP, Hou YC (2017). Aloe activated P-glycoprotein and CYP 3A: a study on the serum kinetics of aloe and its interaction with cyclosporine in rats. Food & function, 8(1):315-22. https://doi.org/10.1039/C6FO00938G

Rodríguez ER, Martín JD, Romero CD (2010). Aloe vera as a functional ingredient in foods. Critical Reviews in Food Science and Nutrition, 50(4):305-26. https://doi.org/10.1080/10408390802544454

Hamman JH (2008). Composition and applications of Aloe vera leaf gel. Molecules, 13(8):1599-616. https://doi.org/10.3390/molecules13081599

Minjares-Fuentes R, Femenia A, Comas-Serra F, Rodríguez-González VM (2018). Compositional and structural features of the main bioactive polysaccharides present in the Aloe vera plant. Journal of AOAC International, 101(6):1711-9. https://doi.org/10.5740/jaoacint.18-0119

Añibarro-Ortega M, Pinela J, Barros L, Ćirić A, Silva SP, Coelho E, Mocan A, Calhelha RC, Soković M, Coimbra MA, Ferreira IC (2019). Compositional features and bioactive properties of aloe vera leaf (Fillet, mucilage, and rind) and flower. Antioxidants, 8(10):444. https://doi.org/10.3390/antiox8100444

Shi XD, Nie SP, Yin JY, Que ZQ, Zhang LJ, Huang XJ (2017). Polysaccharide from leaf skin of Aloe barbadensis Miller: Part I. Extraction, fractionation, physicochemical properties and structural characterization. Food Hydrocolloids, 73:176-83. https://doi.org/10.1016/j.foodhyd.2017.06.039

Lin LX, Wang P, Wang YT, Huang Y, Jiang L, Wang XM (2016). Aloe vera and Vitisvinifera improve wound healing in an in vivo rat burn wound model. Molecular medicine reports, 13(2):1070-6. https://doi.org/10.3892/mmr.2015.4681

Burusapat C, Supawan M, Pruksapong C, Pitiseree A, Suwantemee C (2018). Topical Aloe vera gel for accelerated wound healing of split-thickness skin graft donor sites: A double-blind, randomized, controlled trial and systematic review. Plastic and reconstructive surgery, 142(1):217-26. 10.1097/PRS.0000000000004515

Das S, Mishra B, Gill K, Ashraf MS, Singh AK, Sinha M, Sharma S, Xess I, Dalal K, Singh TP, Dey S (2011). Isolation and characterization of novel protein with anti-fungal and anti-inflammatory properties from Aloe vera leaf gel. International Journal of Biological Macromolecules, 48(1):38-43. https://doi.org/10.1016/j.ijbiomac.2010.09.010

de Oliveira AC, Tabrez S, Shakil S, Khan MI, Asghar MN, Matias BD, da Silva Batista JM, Rosal MM, de Lima MM, Gomes SR, de Carvalho RM (2018). Mutagenic, antioxidant and wound healing properties of Aloe vera. Journal of ethnopharmacology, 227:191-7. https://doi.org/10.1016/j.jep.2018.08.034

Dat AD, Poon F, Pham KB, Doust J (2012). Aloe vera for treating acute and chronic wounds. Cochrane Database of Systematic Reviews, (2). https://doi.org/10.1002/14651858.CD008762.pub2

Hashemi SA, Madani SA, Abediankenari S (2015). The review on properties of Aloe vera in healing of cutaneous wounds. BioMed research international. https://doi.org/10.1155/2015/714216

Hormozi M, Assaei R, Boroujeni MB (2017). The effect of aloe vera on the expression of wound healing factors (TGFβ1 and bFGF) in mouse embryonic fibroblast cell: In vitro study. Biomedicine & Pharmacotherapy, 88:610-6. https://doi.org/10.1016/j.biopha.2017.01.095

Budai MM, Varga A, Milesz S, Tőzsér J, Benkő S (2013). Aloe veradownregulates LPS-induced inflammatory cytokine production and expression of NLRP3 inflammasome in human macrophages. Molecular immunology, 56(4):471-9. https://doi.org/10.1016/j.molimm.2013.05.005

zadehGharaboghaz MN, Farahpour MR, Saghaie S (2020). Topical co-administration of Teucriumpoliumhydroethanolic extract and Aloe vera gel triggered wound healing by accelerating cell proliferation in diabetic mouse model. Biomedicine & Pharmacotherapy, 127:110189. https://doi.org/10.1016/j.biopha.2020.110189

Oryan A, Mohammadalipour A, Moshiri A, Tabandeh MR (2016). Topical application of Aloe vera accelerated wound healing, modeling, and remodeling: an experimental study. Annals of plastic surgery, 77(1):37-46. 10.1097/SAP.0000000000000239

Tabandeh MR, Oryan A, Mohammadalipour A (2014). Polysaccharides of Aloe vera induce MMP-3 and TIMP-2 gene expression during the skin wound repair of rat. International journal of biological macromolecules, 65:424-30. https://doi.org/10.1016/j.ijbiomac.2014.01.055

Xing W, Guo W, Zou CH, Fu TT, Li XY, Zhu M, Qi JH, Song J, Dong CH, Li Z, Xiao Y (2015). Acemannan accelerates cell proliferation and skin wound healing through AKT/mTOR signaling pathway. Journal of Dermatological Science, 79(2):101-9. https://doi.org/10.1016/j.jdermsci.2015.03.016

Chokboribal J, Tachaboonyakiat W, Sangvanich P, Ruangpornvisuti V, Jettanacheawchankit S, Thunyakitpisal P (2015). Deacetylation affects the physical properties and bioactivity of acemannan, an extracted polysaccharide from Aloe vera. Carbohydrate polymers, 133:556-66. https://doi.org/10.1016/j.carbpol.2015.07.039

Liu C, Cui Y, Pi F, Cheng Y, Guo Y, Qian H (2019). Extraction, purification, structural characteristics, biological activities and pharmacological applications of acemannan, a polysaccharide from aloe vera: A review. Molecules, 24(8):1554. https://doi.org/10.3390/molecules24081554

Priya SG, Gupta A, Jain E, Sarkar J, Damania A, Jagdale PR, Chaudhari BP, Gupta KC, Kumar A (2016). Bilayer cryogel wound dressing and skin regeneration grafts for the treatment of acute skin wounds. ACS applied materials & interfaces, 8(24):15145-59. https://doi.org/10.1021/acsami.6b04711

Boudreau MD, Beland FA (2006). An evaluation of the biological and toxicological properties of Aloe barbadensis (miller), Aloe vera. Journal of Environmental Science and Health Part C, 24(1):103-54. https://doi.org/10.1080/10590500600614303

Li LJ, Gao SQ, Peng LH, Wang XR, Zhang Y, Hu ZJ, Gao JQ (2017). Evaluation of efficacy of aloin in treating acute trauma in vitro and in vivo. Biomedicine & Pharmacotherapy, 88:1211-9. https://doi.org/10.1016/j.biopha.2017.01.174

Di Luccia B, Manzo N, Vivo M, Galano E, Amoresano A, Crescenzi E, Pollice A, Tudisco R, Infascelli F, Calabrò V (2013). A biochemical and cellular approach to explore the antiproliferative and prodifferentiative activity of Aloe arborescens leaf extract. Phytotherapy Research, 27(12):1819-28.

Lee W, Jeong GS, Baek MC, Ku SK, Bae JS (2019). Renal protective effects of aloin in a mouse model of sepsis. Food and Chemical Toxicology, 132:110651. https://doi.org/10.1016/j.fct.2019.110651

Silva MA, Trevisan G, Hoffmeister C, Rossato MF, Boligon AA, Walker CI, Klafke JZ, Oliveira SM, Silva CR, Athayde ML, Ferreira J (2014). Anti-inflammatory and antioxidant effects of Aloe saponaria Haw in a model of UVB-induced paw sunburn in rats. Journal of Photochemistry and photobiology B: Biology, 133:47-54. https://doi.org/10.1016/j.jphotobiol.2014.02.019

Du, Y., Qian, B., Gao, L.,et al (2019). Aloin preconditioning attenuates hepatic ischemia/reperfusion injury via in-hibiting TLR4/MyD88/NF-kB signal pathway in vivo and in vitro.Oxid Med Cell Longev 3765898.

Luo X, Zhang H, Wei X, Shi M, Fan P, Xie W, Zhang Y, Xu N (2018). Aloin suppresses lipopolysaccharide-induced inflammatory response and apoptosis by inhibiting the activation of NF-κB. Molecules, 23(3):517. https://doi.org/10.3390/molecules23030517

Park MY, Kwon HJ, Sung MK (2009). Evaluation of aloin and aloe-emodin as anti-inflammatory agents in aloe by using murine macrophages. Bioscience, Biotechnology, and Biochemistry, 73(4):828-32. https://doi.org/10.1271/bbb.80714

Sun H, Luo G, Chen D, Xiang Z (2016). A comprehensive and system review for the pharmacological mechanism of action of rhein, an active anthraquinone ingredient. Frontiers in pharmacology, 7:247. https://doi.org/10.3389/fphar.2016.00247

Choi SW, Son BW, Son YS, Park YI, Lee SK, Chung MH (2001). The wound‐healing effect of a glycoprotein fraction isolated from aloe vera. British Journal of Dermatology, 145(4):535-45.

Choi S, Kim KW, Choi JS, Han ST, Park YI, Lee SK, Kim JS, Chung MH (2002). Angiogenic activity of β-sitosterol in the ischaemia/reperfusion-damaged brain of Mongolian gerbil. Plantamedica, 68(04):330-5. 10.1055/s-2002-26750

Liao PC, Lai MH, Hsu KP, Kuo YH, Chen J, Tsai MC, Li CX, Yin XJ, Jeyashoke N, Chao LK (2018). Identification of β-sitosterol as in vitro anti-inflammatory constituent in Moringaoleifera. Journal of agricultural and food chemistry, 66(41):10748-59. https://doi.org/10.1021/acs.jafc.8b04555

Wahedi HM, Jeong M, Chae JK, Do SG, Yoon H, Kim SY (2017). Aloesin from Aloe vera accelerates skin wound healing by modulating MAPK/Rho and Smad signaling pathways in vitro and in vivo. Phytomedicine, 28:19-26. https://doi.org/10.1016/j.phymed.2017.02.005

Hobson R (2016). Vitamin E and wound healing: an evidence‐based review. International wound journal, 13(3):331-5.

Sinno S, Lee DS, Khachemoune A (2011). Vitamins and cutaneous wound healing. Journal of wound care, 20(6):287-93. https://doi.org/10.12968/jowc.2011.20.6.287

Ahmad S, Ali M, Ansari SH, Ahmed F (2011). Phytoconstituents from the rhizomes of Curcuma aromaticaSalisb. Journal of Saudi Chemical Society, 5(3):287-90. https://doi.org/10.1016/j.jscs.2010.10.011

Pant N, Misra H, Jain DC (2013). Phytochemical investigation of ethyl acetate extract from Curcuma aromaticaSalisb. rhizomes. Arabian Journal of Chemistry, 6(3):279-83. https://doi.org/10.1016/j.arabjc.2010.10.007

Revathi S, Malathy NS (2013). Antibacterial activity of rhizome of Curcuma aromatica and partial purification of active compounds. Indian journal of pharmaceutical sciences, 75(6):732.

Quality standards of Indian medicinal plants. Edn 1, Vol. 6, Indian Council of medical Research, RamalingaswamiBhawan, 2008, 102- 109.

Kumar A, Chomwal R, Kumar P, Sawal R (2009). Anti inflammatory and wound healing activity of Curcuma aromaticasalisb extract and its formulation. Journal of Chemical and Pharmaceutical Research, 1(1):304-10.

Liu B, Gao YQ, Wang XM, Wang YC, Fu LQ (2014). Germacrone inhibits the proliferation of glioma cells by promoting apoptosis and inducing cell cycle arrest. Molecular medicine reports, 10(2):1046-50. https://doi.org/10.3892/mmr.2014.2290

Wu WY, Xu Q, Shi LC, Zhang WB (2000). Inhibitory effects of Curcuma aromatica oil on proliferation of hepatoma in mice. World Journal of Gastroenterology, 6(2):216. https://dx.doi.org/10.3748%2Fwjg.v6.i2.216

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2021-12-30
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DOI: 10.54393/pbmj.v4i2.141
Published: 2021-12-30

How to Cite

Jamil, M., Kashif, M. ., Ahmad, B. ., Sadia, B. ., Khan, I. ., Qazi, I. ., Khan, M. F. ., Ali, M. ., Rasheed, M. ., & Arif, M. R. . (2021). Wound Healing Efficacy of Hondy, Aloe Vera, and Turmeric: Wound Healing Efficacy of Hondy, Aloe Vera, and Turmeric. Pakistan BioMedical Journal, 4(2), 26–35. https://doi.org/10.54393/pbmj.v4i2.141

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