Epidemiology of Squamous Cell Carcinoma in Response to Different Hazardous Chewing Causes in Lahore, Pakistan-a Unicenter study: epidemiology of oral carcinoma in Lahore, Pakistan

Maria Fareed  Siddiqui; Umair  Yaqoob

doi:10.52229/pbmj.v2i2.20

Authors

Maria Fareed Siddiqui Department of Pharmacy, University of Lahore, Lahore, Pakistan
Umair Yaqoob Institute of Molecular Biology and Biotechnology, University of Lahore, Lahore, Pakistan

DOI:

https://doi.org/10.52229/pbmj.v2i2.20

Abstract

Oral squamous cell carcinoma (OSCC)being the world’s most prevailing and frightening cancerous disorder lacks the sufficient data in Pakistan despite of its higher magnitude and prevalence. Objective:This study was specifically designed and conducted with the aim to identify the frequency of this disorder along with causative factors in past three years in a tertiary care hospital of Lahore, Pakistan.Methods:Epidemiological study was conducted using retrospective randomized method and all pre-requisites were filled.The clinical profiles of patients were collected from Maxillofacial and Oral Surgery Departmentof Pathology, Mayo Hospital Lahore. Patients who had undergone treatment for OSCC were contacted and interviewed for information about demographic regions, previous history of malignancy, disease onset, chewing habits, exposure to pesticides, industrial exposure to metals etc. and all particulars were not and compiled on questionnaire. Results:A total of 54 patients from different districts of Punjab participated in the study.Percentages for each possible causative chewing habit were calculated and 87.50 % of population was found addicted to different habits. Genetic factor might have contributed in remaining for development of OSCC.Conclusions:Informative data provided in this study will be helpful to be used by the government and private health agencies while designing and planning management of oral health problems and allocating health budgets in focusing this issue

References

White AC, Tran K, Khuu J, et al (2011). Defining the origins of Ras/p53-mediated squamous cell carcinoma. Proc Natl Acad Sci. 108:7425-30.

Bhurgri Y, Faridi N, Ayub M, et al (2000). Lipoma of the bone. JPMA. 50: 168-9.

de Camargo Cancela M, Voti L, Guerra-Yi M, et al (2010). Oral cavity cancer in developed and in developing countries: population-based incidence. Head Neck. 32:357-67.

Ali M, Sundaram D (2012). Biopsied oral soft tissue lesions in Kuwait: a six-year retrospective analysis. Med Princ Pract, 21:569-75.

Siddiqui MF, Sadiq E, Qazi MH (2015). Intrinsic Mitochondrial Apoptotic Pathways; an Imperative Feature of Cisplatin Cytotoxicty. Int J Pharm Sci Res.6: 31-41.

Richard Bauer, Albert Dowejko, Oliver Driemel, et al (2008). Truncated P-cadherin is produced in oral squamous cell carcinoma.FEBSJ.275: 4198–4210.

Shenoi R, Devrukhkar V, Sharma BK, et al (2012). Demographic and clinical profile of oral squamous cell carcinoma patients: a retrospective study. Indian J Cancer. 49:21-6.

Koduganti RR, Sehrawat S, Reddy PV (2012). Gingival squamous cell carcinoma: A diagnostic impediment. J Indian Soc Periodontol. 16:104-7.

Udeabor SE, Rana M, Wegener G, et al (2012). Squamous cell carcinoma of the oral cavity and the oropharynx in patients less than 40 years of age: a 20-year analysis. Head Neck Oncol. 4: 1-7.

Tettamanti L, Caprioglio A, Tecco S, et al (2012). Oral Squamous Cell Carcinoma in the paediatric patient: a literature review. Eur J Paediatr Dent. 13:35-40.

Mansoor A. Khan, SaimaSaleem , Syed M. Shahid, et al. Prevalence of oral squamous cell carcinoma (OSCC) in relation to different chewing habits in Karachi, Pakistan. Pak. J. Biochem. Mol. Biol 2012; 45(2): 59-63.

Vilas-Boas F, Magro F, Balhau R, et al (2012). Oral squamous cell carcinoma in a Crohn's disease patient taking azathioprine: case report and review of the literature. J Crohns Colitis. 6:792-5.

Iguchi H, Hashimoto K, Sunami K, et al (2003). A case of advanced lateral wall oropharyngeal carcinoma showing complete response to chemotherapy with TS-1. Gan To Kagaku Ryoho. 30:101-4.

Kajikawa H, Nario K, Miyahara H (2004). A case of neck metastasis from hypopharyngeal carcinoma successfully treated with TS-1. Gan To Kagaku Ryoho. 31:631-4.

Wong WM, Parvathaneni U, Jewell PD, et al (2012). Squamous cell carcinoma of the oral tongue in a patient with Fanconi anemia treated with radiotherapy and concurrent cetuximab: A case report and review of the literature. Head Neck. 35.

Bile KM, Shaikh JA, Afridi HU, et al (2010). Smokeless tobacco use in Pakistan and its association with oropharyngeal cancer. East Mediterr Health. 16.

Peng, Q., Wang, Y., Quan, H., Li, Y., & Tang, Z. (2016). Oral verrucous carcinoma: From multifactorial etiology to diverse treatment regimens. International journal of oncology, 49(1), 59-73.

Mehboob, R., Tanvir, I., Warraich, R. A., Perveen, S., Yasmeen, S., & Ahmad, F. J. (2015). Role of neurotransmitter Substance P in progression of oral squamous cell carcinoma. Pathology-Research and Practice, 211(3), 203-207.

Huo, M., Panizza, B., Bernard, A., &Porceddu, S. V. (2018). Head and neck squamous cell carcinoma of unknown primary: Outcomes of a pre-defined institutional treatment policy in a region with a high prevalence of skin cancer. Oral oncology, 77, 43-48.

Ganjre, A. P. (2018). Significance of documentation of secondhand smoke in history taking procedure of head and neck squamous cell carcinoma patients with no tobacco habit. Journal of cancer research and therapeutics, 14(5), 1162.

D’Silva, N. J., &Gutkind, J. S. (2019). Oral cancer: Integration of studies for diagnostic and therapeutic precision. Advances in dental research, 30(2), 45-49.

Solomon, B., Young, R. J., &Rischin, D. (2018, October). Head and neck squamous cell carcinoma: genomics and emerging biomarkers for immunomodulatory cancer treatments. In Seminars in cancer biology (Vol. 52, pp. 228-240). Academic Press.

Villagómez-Ortíz, V. J., Paz-Delgadillo, D. E., Marino-Martínez, I., Cesenas-Falcón, L. Á., Sandoval-de la Fuente, A., & Reyes-Escobedo, A. (2016). Prevalence of human papillomavirus infection in squamous cell carcinoma of the oral cavity, oropharynx and larynx. Cirugía y Cirujanos (English Edition), 84(5), 363-368.

Leemans, C. R., Snijders, P. J., &Brakenhoff, R. H. (2018). The molecular landscape of head and neck cancer. Nature Reviews Cancer, 18(5), 269.