Management of Type II Diabetes Mellitus using Adult Autologous Adipose derived stem cells with Platelets Rich Plasma (PRP): Management of T2DM using stem cells with PRP

Shahzad  Anwar; Ayesha  Nawaz; Zaigham  Abbas

doi:10.54393/pbmj.v5i4.364

Authors

Shahzad Anwar Iffat Anwar Medical Complex, Awaisia Housing Scheme, Lahore, Pakistan
Ayesha Nawaz Institute of Microbiology and Molecular Genetics, University of the Punjab, Quaid-e-Azam Campus, Lahore, Pakistan
Zaigham Abbas Institute of Microbiology and Molecular Genetics, University of the Punjab, Quaid-e-Azam Campus, Lahore, Pakistan

DOI:

https://doi.org/10.54393/pbmj.v5i4.364

Abstract

Type II diabetes mellitus (T2DM) is known as non-insulin dependent diabetes mellitus. Insulin impairment and insulin resistance are the major causes of type II diabetes mellitus. People with T2DM are more prone to macro-vascular and micro vascular impediments. Adult Autologous Adipose derived stem cells (ADSC) hold potential to develop into multilineages and they can secrete numerous growth factors that can regenerate the damaged neighboring cells. The chronic wound healing processes and diabetes-associated complications are reported to be treated by using stem cells by revascularization and by promoting the micro vascular remodeling. Objective: To evaluate the safety and efficacy of Adipose derived autologous stem cells and PRP in patients suffering from Type 2 Diabetes Mellitus (T2DM). Methods: We reported three cases aged 50, 69 and 72 years suffering from T2DM since 20, 10 and 20 years respectively. They were treated with adult autologous ADSC and Platelets Rich Plasma (PRP). Results: Over a follow up of twelve months significant control in glycemia as well as stable glycosylated hemoglobin with decrease in pain on Visual Analogous scale (VAS) score has been observed

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