Cytotoxic Assessment of Quinoline Based Derivatives on  Liver Cancer Cell Line : Quinoline compounds and their Cytotoxicity

Maria  Fareed; MH  Qazi; Sarfaraz  Ahmed; Sana  Awan; Aamer  Qazi

doi:10.52229/pbmj.v1i2.43

Authors

Maria Fareed Centre for Research in Molecular Medicine, University of Lahore, Lahore, Pakistan
MH Qazi Centre for Research in Molecular Medicine, University of Lahore, Lahore, Pakistan
Sarfaraz Ahmed Institute of Molecular Biology & Biotechnology, University of Lahore, Lahore, Pakistan
Sana Awan Institute of Molecular Biology & Biotechnology, University of Lahore, Lahore, Pakistan
Aamer Qazi Institute of Molecular Biology & Biotechnology, University of Lahore, Lahore, Pakistan

DOI:

https://doi.org/10.52229/pbmj.v1i2.43

Abstract

Current scenario of newer diseases with multiple causes has drawn the attention of the researchers in the field of therapeutics and they are now inclined to identify molecules effective for targeted therapy. Objective: Quinoline (1-azanaphthalene); belongs to heterocyclic aromatic nitrogen compound. Some quinoline-based derivatives are also known for their anti-tumor activity. The study was planned to evaluate the cytotoxic potential of quinoline derivatives. Methods: Berberine; a quinoline compound was made part of study to make structural analogs which were docked against potential target proteins. Cytotoxic profiling of all derivatives was done using MTT cytotoxicity assay. Results: The pharmacoinformatic and structure activity relationship studies of analogs were done. The cytotoxic profiles were elucidated by comparing viability rates of analogs treated hepatic cancerous cell line with untreated hepatic cells and untreated mesenchymal stem cells as standards. Marked cytotoxicity was seen in all molecules at low doses than reported in past studies with relevance to parent compound. Conclusions: The results will be further confirmed through various other cell culture assays targeting different marker proteins, pharmacoinformatics tools and structure activity relationship studies

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