Efficacy And Surgical Outcome of Trabeculectomy with Mitomycin-C In Congenital Glaucoma with Hazy Cornea

Outcome of Trabeculectomy with Mitomycon-C in Congenital Glaucoma

Authors

  • Muhammad Hassaan Ali Allama Iqbal Medical College, Jinnah Hospital, Lahore, Pakistan
  • Syed Raza Ali Shah Allama Iqbal Medical College, Jinnah Hospital, Lahore, Pakistan
  • Ayeza Nadeem Butt Services Institute of Medical Sciences, Services Hospital, Lahore, Pakistan
  • Samreen Jamal King Edward Medical University, Mayo Hospital, Lahore
  • Uzma Hamza Allama Iqbal Medical College, Jinnah Hospital, Lahore, Pakistan
  • Nadeem Hafeez Butt Allama Iqbal Medical College, Jinnah Hospital, Lahore, Pakistan

DOI:

https://doi.org/10.54393/pbmj.v5i5.458

Keywords:

congenital glaucoma, outcome, trabeculectomy, mitomycin C

Abstract

Glaucoma is characterized by an optic neuropathy associated with raised intraocular pressure (IOP)  and visual field defect Objective: To determine the efficacy and outcome of trabeculectomy augmented with anti-metabolite mitomycin-C in children with childhood glaucoma. Methods: A total of 40 eyes of 22 diagnosed cases of congenital glaucoma were studied. All these children underwent mitomycin-C augmented trabeculectomy from July 2017 to August 2020. The primary outcome was control of postoperative intraocular pressure (IOP) at the end of one year. A target pressure of <15mmHg was set as target pressure to label a successful surgical outcome. Results: The mean age of the patients enrolled in the study was 26.8± 12.2 years (range: 8 – 32 months) with a male to female ratio of 7:4. The mean ± SD IOP before trabeculectomy surgery was (31.5± 8.6) (range: 21 – 53) mmHg. At the one-year follow-up, the mean postoperative IOP was (19.4± 7.9) (range: 9 – 48) mmHg. Target IOP < 15 mmHg was successfully achieved in 27 (67.5%), 24 (60.0%) and 22 (55.0%) eyes at postoperative 1, 6 and 12 months respectively. Repeat trabeculectomy was required in 5 (12.5%) eyes, while 5 (12.5%) eyes developed corneal perforations and 3 (7.5%) eyes developed phthisis bulbi. Conclusion: Trabeculectomy with mitomycin C can be a primary surgical intervention in congenital glaucoma. However, repeat surgery may be required and other related surgical complications can occur after this surgery in patients with uncontrolled IOP.

Author Biographies

Muhammad Hassaan Ali, Allama Iqbal Medical College, Jinnah Hospital, Lahore, Pakistan

MBBS, FCPS(Ophthalmology), FCPS(Vitreoretinal Surgery)

Fellowship in Pediatric Ophthalmology & Strabismus (Stein Eye, USA)

Senior Registrar, Department of Ophthalmology

Allama Iqbal Medical College, Jinnah Hospital, Lahore, Pakistan

Address: 388-D, DHA Phase XII (EME), Canal Road, Lahore, Pakistan 53710

Syed Raza Ali Shah, Allama Iqbal Medical College, Jinnah Hospital, Lahore, Pakistan

MBBS, MS(Ophthalmology), Fellowship in Vitreoretina (KEMU),

MSc(Preventive Ophthalmology)

Associate Professor of Ophthalmology, Department of Ophthalmology

Allama Iqbal Medical College, Jinnah Hospital, Lahore, Pakistan

Ayeza Nadeem Butt, Services Institute of Medical Sciences, Services Hospital, Lahore, Pakistan

House Officer, Services Institute of Medical Sciences, Services Hospital, Lahore, Pakistan

Samreen Jamal, King Edward Medical University, Mayo Hospital, Lahore

MBBS, FCPS(Ophthalmology)

Fellowship in Pediatric Ophthalmology & Strabismus (KEMU, Pak)

Senior Registrar, Department of Ophthalmology

King Edward Medical University, Mayo Hospital, Lahore

Uzma Hamza, Allama Iqbal Medical College, Jinnah Hospital, Lahore, Pakistan

MBBS, FCPS(Ophthalmology)

Assistant Professor of Ophthalmology, Department of Ophthalmology

Allama Iqbal Medical College, Jinnah Hospital, Lahore, Pakistan

Nadeem Hafeez Butt, Allama Iqbal Medical College, Jinnah Hospital, Lahore, Pakistan

MBBS, FCPS(Ophth), FRCSEd(Ophth), FRCS(Glasgow), MHPE

Professor and Head of Ophthalmology Department

Allama Iqbal Medical College, Jinnah Hospital, Lahore, Pakistan

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Published

2022-05-31

How to Cite

Ali, M. H., Shah, S. R. A., Butt, A. N., Jamal, S., Hamza, U., & Butt, N. H. (2022). Efficacy And Surgical Outcome of Trabeculectomy with Mitomycin-C In Congenital Glaucoma with Hazy Cornea: Outcome of Trabeculectomy with Mitomycon-C in Congenital Glaucoma. Pakistan BioMedical Journal, 5(5), 272–275. https://doi.org/10.54393/pbmj.v5i5.458

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