Bioactive Profile and Health Claims of Ginkgo biloba

Bioactive Profile and Health Claims of Ginkgo biloba

Authors

  • Muhammad Aqib Saeed University Institute of Diet and Nutritional Sciences, Faculty of Allied Health Sciences, The University of Lahore, Lahore, Pakistan
  • Huma Bader Ul Ain University Institute of Diet and Nutritional Sciences, Faculty of Allied Health Sciences, The University of Lahore, Lahore, Pakistan
  • Hafiza Nazia Koser University Institute of Diet and Nutritional Sciences, Faculty of Allied Health Sciences, The University of Lahore, Lahore, Pakistan
  • Bahisht Rizwan University Institute of Diet and Nutritional Sciences, Faculty of Allied Health Sciences, The University of Lahore, Lahore, Pakistan
  • Tabussam Tufail University Institute of Diet and Nutritional Sciences, Faculty of Allied Health Sciences, The University of Lahore, Lahore, Pakistan
  • Muhammad Abdullah Wheat Research Institute, AARI, Faisalabad, Pakistan
  • Farrukh Jawad Alvi University Institute of Diet and Nutritional Sciences, Faculty of Allied Health Sciences, The University of Lahore, Lahore, Pakistan
  • Asifa Saleem University Institute of Diet and Nutritional Sciences, Faculty of Allied Health Sciences, The University of Lahore, Lahore,
  • Sahar Imran University Institute of Diet and Nutritional Sciences, Faculty of Allied Health Sciences, The University of Lahore, Lahore, Pakistan
  • Fatima Zahra University Institute of Diet and Nutritional Sciences, Faculty of Allied Health Sciences, The University of Lahore, Lahore, Pakistan

DOI:

https://doi.org/10.54393/pbmj.v5i5.460

Keywords:

Therapeutic, Anti-inflammatory, Anti-diabetic, Cardiovascular Diseases, Neurological Diseases, Flavonoids, Terpenoids, Hyperglycemia, Hyperlipidemia

Abstract

Ginkgo biloba also known as ‘maidenhair tree’ is a therapeutic herbal medicine consumed by people around the globe and is commonly used to treat neurological and cardiovascular disorders as well as neurological illnesses such as Alzheimer’s disease, dementia, and cognitive impairment. As it is rich in vitamins and has a number of bioactive compounds which are helpful in treating many health-related issues. This review aims to cover the beneficial side of Ginkgo biloba like its pharmacological effects, antidiabetic effects, anti-inflammatory effects, and its role in treating diseases

References

Chan PC, Q Xia, and Fu P Peter, Ginkgo bilobaleave extract: biological, medicinal, and toxicological effects. J. Environ. Sci. Health C. 2007,25(3): 211–244. doi.org/10.1080/10590500701569414

Kushwaha SK, Sharma CS, Singh HP, Ankalgi A, Ranawat MS, et al. Ginkgo biloba a source of bioactive natural products: a review. Indo Am. J. Pharmaceut. Res. 2014,4(12):5622-9.

Singh B, et al. Biology and chemistry of Ginkgo biloba.Fitoterapia. 2008,79(6): 401–418. doi.org/10.1016/j.fitote.2008.05.007

Youdim K A, and JA Joseph, A possible emerging role of phytochemicals in improving age-related neurological dysfunctions: a multiplicity of effects. Free Radical Biology and Medicine. 2001,30(6): 583-94. doi.org/10.1016/S0891-5849(00)00510-4

Yu YY, Toxic and active compositions and the intervention effect on Alzheimer’s disease of ginkgoseeds. Master's thesis, Jiangsu University 2017.

Vellas B, et al. Long-term use of standardized Ginkgo biloba extract for the prevention of Alzheimer’s disease (GuidAge): a randomized placebo-controlled trial. Lancet Neurol. 2012,11(10): 851–9.doi:10.1016/S1474-4422(12)70206-5

Jaracz S, et al.Ginkgolides and glycine receptors: a structure–activity relationship study. Chemistry–A European Journal. 2004,10(6): 1507-18. doi.org/10.1002/chem.200305473

Gunkle JE, KV Thimann, and RH Wetmore. Studies of development in long shoots and short shoots of Ginkgo biloba L., part IV. Growth habit, shoot expression and the mechanism of its control. Am J Bot. 1949,36: 309–16.

Prajapati ND, Purohit SS, Sharma AK, Kumar T. A handbook of medicinal plants: A complete source book. InA handbook of medicinal plants: a complete source book 2003,554-554.

Anonymous. Combining nutrients for health benefits. Food Technol. 2001,55: 42-47

Li Y, Hu C. Ginkgo biloba L. 银杏 (Yinxing, Baiguo, Ginkgo). InDietary Chinese Herbs 2015,391-402.Springer, Vienna. doi.org/10.1007/978-3-211-99448-1_45

Miao M, et al. Structure and functional properties of starches from Chinese ginkgo (Ginkgo biloba L.) nuts. Food research international.2012,49(1):303-10. doi.org/10.1016/j.foodres.2012.07.038

Spence KE, and J Jane, Chemical and physical properties of ginkgo (Ginkgo biloba) starch. Carbohyd. Polym. 1999,40(4): 261-269. doi.org/10.1016/S0144-8617(99)00059-4

Deng Q, et al. Functional properties of protein isolates, globulin and albumin extracted from Ginkgobiloba seeds. Food Chem. 2011,124: 1458-1465. doi.org/10.1016/j.foodchem.2010.07.108

Wang H and T B Ng, Ginkbilobin, a novel antifungal protein from Ginkgo biloba seeds with sequence similarity to embryo-abundant protein. Biochem. Bioph. Res. Co. 2000, 279:407-411. doi.org/10.1006/bbrc.2000.3929

Sawano Y, et al. Purification, characterization, and molecular gene cloning of an antifungal protein from Ginkgo biloba seeds. Biol. Chem. 2007,388: 273-280. doi.org/10.1515/BC.2007.030

Zhou H, Chen X, Wang C, Ye J, Chen H. Purification and characterization of a novel~ 18 kDa antioxidant protein from Ginkgo biloba seeds. Molecules. 2012, (12):14778-94.

Huang W, et al. Study on separation and purification of protein from ginkgo seed and its antioxidant activity. Scientia Agricultura Sinica. 2004. 37(10):1537-43.

Huang W, et al. Purification and characterization of an antioxidant protein from Ginkgo biloba seeds. Food Res. Int. 2010,43: 86-94 C. doi.org/10.1016/j.foodres.2009.08.015

Wu C, et al. Purification and identification of novel antioxidant peptides from enzymatic hydrolysate of Ginkgo biloba seed proteins. Food Sci. Tech. Res. 2013,19(6):1029-35. doi.org/10.3136/fstr.19.1029

Chen Q, GW Yang, and LG An, Apoptosis of hepatomacells SMMC-7721 induced by Ginkgobiloba seed polysaccharide. World J.Gastroenterol. 2002,8:832-836. doi.org/10.3748%2Fwjg.v8.i5.832

Fan LH, Wang KZ, Cheng B. Effects of Ginkgo biloba extract on lipid peroxidation and apoptosis after spinal cord ischemia/reperfusion in rabbits. Chinese Journal of Traumatology. 2006,9(02):77-81.

Mahadevan S, and Y Park. Multifaceted therapeutic benefits of Ginkgo biloba L.: chemistry, efficacy, safety, and uses. Journal of food science. 2008,73(1): R14-R19. doi.org/10.1111/j.1750-3841.2007. 00597.x

Ma YC, et al. An effective identification and quantification method for Ginkgobiloba flavonol glycosides with targeted evaluation of adulterated products. Phytomedicine. 2016,23: 377-387. doi.org/10.1016/j.phymed.2016.02.003

Jose Abad M, L Miguel Bedoya, and P Bermejo. An update on drug interactions with the herbal medicine Ginkgo biloba. Current drug metabolism. 2010,11(2): 171-81. doi.org/10.2174/138920010791110818

Lin LZ, et al. Chromatographic profiles and identification of new phenolic components of Ginkgo biloba leaves and selected products. Journal of agricultural and food chemistry. 2008,56(15): 6671-9. doi.org/10.1021/jf800488x

Goh LML and PJ Barlow. Flavonoid recovery and stability from Ginkgo biloba subjected to a simulated digestion process. Food Chem. 2004,86:195–202. https://www.infona.pl/resource/bwmeta1.element.elsevier-907aeff3-3332-33fc-a11b-84018c50a323

Mahady GB. Ginkgobiloba for the prevention and treatment of cardiovascular disease: a review of the literature. J. Cardiovasc Nurs 2002,16: 21–32. doi.org/10.1097/00005082-200207000-00004

Zhang QM and MG Gong. Extraction optimization and antioxidant activity of total flavonoids from ginkgonut. Food Sci. Technol. 2014,39:231-234. (InChinese) doi.org/10.3390%2Fmolecules23051167

Meilin W, Chunshan Z, Longsheng C, Shi Z, Fangfang G. Study on the Extraction of total flavonoids from ginkgo leaves by enzyme hydrolysis. Natural Product Research and Development. 2004,16(6):557-60.

Xiong, et al. Ginkgetin exerts growth inhibitory and apoptotic effects on osteosarcoma cells through inhibition of STAT3 andactivationofcaspase-3/9.Oncol. Rep. 2016,35: 1034-1040. doi.org/10.3892/or.2015.4427

Kang JW, et al. Kaempferol and quercetin, components of Ginkgo biloba extract (EGb 761), induce caspase‐3‐dependent apoptosis in oral cavity cancer cells. Phytotherapy Research. 2010,24(S1): S77-82. doi.org/10.1002/ptr.2913

Baek SH, et al. Ginkgetin blocks constitutive STAT3 activation and induces apoptosis through induction of SHP-1 and PTEN tyrosine phosphatases. Phytother. Res. 2016,30: 567-576. doi.org/10.1002/ptr.5557

You O H, et al. Ginkgetin induces apoptosis via activation of caspase and inhibition of survival genes in PC-3 prostate cancer cells. Bioorg. Med. Chem. Lett. 2013,23: 2692-2695. doi.org/10.1016/j.bmcl.2013.02.080

Yamashita Y, Sugimoto Y, and Fuwa H, Developmental changes in properties of ginkgo (GinkgobilobaL.) nut starches. J. Home Econ Japan 41. 1990,723-732. doi.org/10.11428/jhej1987.41.723

Ahlemeyer B, et al. Ginkgolicacids induce neuronaldeath and activate protein phosphatasetype-2C. Eur. J. Pharmacol. 2001,430: 1-7. doi.org/10.1016/S0014-2999(01)01237-7

Mullaicharam AR. A review on evidence-based practice of Ginkgo biloba in brain health. Int. J. Pharmaceut. Chem. Anal. 2013,1:24-30.

Augustin S, et al. Effect of a short-and long-term treatment with Ginkgo biloba extract on amyloid precursor protein levels in a transgenic mouse model relevant to Alzheimer's disease. Arch Biochem Biophys. 2009,481(2):177-1782. doi.org/10.1016/j.abb.2008.10.032

Kobayashi D, et al. Toxicity of 4'-O-methylpyridoxine-5'-glucoside in Ginkgobiloba seeds. Food Chem. 2011,126: 1198-1202. doi.org/10.1016/j.foodchem.2010.12.001

Hori Y, et al. Rapid analysis of4 Omethylpyridoxine in the serum of patients with Ginkgo biloba seed poisoning by ion-pair high-performance liquidchromatography. Biol. Pharm.Bull. 2004,27: 486-491. doi.org/10.1248/bpb.27.486

Heinonen,T., and G Wilhelm,Crossmatchingobservationsontoxicologicalandclinicaldatafor the assessment of tolerability and safety of Ginkgo biloba leaf extract. Toxicology. 2015,327: 95–115. doi.org/10.1016/j.tox.2014.10.013

Houghton PJ. Synergy and polyvalence: paradigms to explain the activity of herbal products. Evaluation of herbal medicinal products. 2009,85:94.

Dugoua JJ, Mills E, Perri D, Koren G. Safety and efficacy of ginkgo (Ginkgo biloba) during pregnancy and lactation. Can J Clin Pharmacol. 2006,13(3):e277-84

Aragno M, et al. Oxidative stress-dependent impairment of cardiac-specific transcription factors in experimental diabetes. Endocrinology. 2006,147(12),5967–5974.doi.org/10.1210/en.2006-0728

Tsiotra P C, C Tsigos, and S A.Raptis. TNF-alpha and leptin inhibit basal andglucose-stimulated insulin secretion and gene transcription in the HIT-T15 pancreatic cells. International Journal of Obesity and Related Metabolic Disorders: Journal of the International Association for the Study of Obesity. 2001,25(7): 1018–1026.doi.org/10.1038/sj.ijo.0801657

Tao W, et al. Regulation effects on abnormal glucose and lipid metabolism of TZQ-F, a new kind of Traditional Chinese Medicine. Journal of Ethnopharmacology, 2010,128(3): 575–582.doi.org/10.1016/j.jep.2010.01.044

Downloads

Published

2022-05-31
CITATION
DOI: 10.54393/pbmj.v5i5.460
Published: 2022-05-31

How to Cite

Aqib Saeed, M. ., Bader Ul Ain, H. ., Nazia Koser, H., Rizwan, B. ., Tufail, T. ., Abdullah, M. ., Jawad Alvi, F. ., Saleem, A. ., Imran, S. ., & Zahra, F. (2022). Bioactive Profile and Health Claims of Ginkgo biloba: Bioactive Profile and Health Claims of Ginkgo biloba. Pakistan BioMedical Journal, 5(5), 06–11. https://doi.org/10.54393/pbmj.v5i5.460

Issue

Section

Review Article

Plaudit

Most read articles by the same author(s)

<< < 1 2 3 4 5 > >>