Severe Coronary Problems in Kidney Illness: Medical and Therapeutic Features: Severe Coronary Problems in Kidney Illness

Niaz  Hussain Abassi; Khalid  Hussain Soomro; Abdul  Qadir Bhutto; Shah  Muhammad Babar; Ali Asad; Muhammad  Aslam

doi:10.54393/pbmj.v5i6.529

Authors

Niaz Hussain Abassi Pir Abdul Qadir Shah Jeelani Institute of Medical Sciences Gambat
Khalid Hussain Soomro Pir Abdul Qadir Shah Jeelani Institute of Medical Sciences Gambat
Abdul Qadir Bhutto Pir Abdul Qadir Shah Jeelani Institute of Medical Sciences Gambat
Shah Muhammad Babar Intervention Cardiology Fellow NICVD, Karachi
Ali Asad Intervention Cardiology Fellow NICVD, Karachi
Muhammad Aslam NICVD, Nawab Shah

DOI:

https://doi.org/10.54393/pbmj.v5i6.529

Keywords:

CKD, angiography, natriuretic peptide, myocardial infraction, CAD

Abstract

CAD (coronary artery disease) has a link with the long-lasting kidney issues. The people suffering from some kidney issue may develop coronary artery disorder and its risk factors are very similar to the risk factors in other cases. Objective: To assess the parameters of CKD (coronary kidney disease) and CAD (coronary artery disease). There was need for the establishment of some efficient predictive methods or biomarkers for the indication of the coronary disorder. Methods: To proceed with this study 301 patients were selected. All of these patients were admitted in the cardiology ward of the hospital. Among them 151 patients had ACS along with CDK while on the other hand, 150 patients had ACS but they do not have any coronary artery disease. Both categories of the patients had made, according to the presence or absence of coronary artery disease. The progression of Coronary disease was estimated by KDIGO (improving global outcome). Results: For the prediction of results, all the attributes related to kidney issues as well as coronary artery were analyzed. Different parameters like disease history of the patients, regulatory parameter of both ACS and CKD, cardio graphical results and angiography states, were carefully estimated for both categories. The characteristics related to increased level of myocardial infarction indicated by STEMI. All these inferred that the level of initiation of coronary disease is much higher in the group without chronic kidney disease. It was estimated about 42 %. However, in the case of CKD group having coronary issues, the raise of non-segmented myocardial infarction is lower (28 %). Conclusion: There is increased level of CAD in case of kidney disease and in CAD. The different indicators and markers for the coronary and kidney disease as well as different cardiological methods were assessed in this study.

References

Yamamoto S, Kon V. Mechanisms for increased cardiovascular disease in chronic kidney dysfunction. Current opinion in nephrology and hypertension. 2009 May; 18(3):181-8. doi: 10.1097/mnh.0b013e328327b360.

Deo R, Fyr CL, Fried LF, Newman AB, Harris TB, Angleman S, Green C, et al. Health ABC study. Kidney dysfunction and fatal cardiovascular disease--an association independent of atherosclerotic events: results from the Health, Aging, and Body Composition (Health ABC) study. American heart journal. 2008 Jan; 155(1):62-8. doi: 10.1016/j.ahj.2007.08.012.

Vanholder R, Massy Z, Argiles A, Spasovski G, Verbeke F, Lameire N; European Uremic Toxin Work Group. Chronic kidney disease as cause of cardiovascular morbidity and mortality. Nephrol Dial Transplant. 2005 Jun; 20(6):1048-56. doi: 10.1093/ndt/gfh813.

Levin A. Clinical epidemiology of cardiovascular disease in chronic kidney disease prior to dialysis. Oxford, UK: Blackwell Science Inc. InSeminars in Dialysis. 2003 Mar-Apr;16(2):101-5. doi: 10.1046/j.1525-139x.2003.16025. x.

Lopes NH, da Silva Paulitsch F, Pereira A, Garzillo CL, Ferreira JF, Stolf N, et al. Mild chronic kidney dysfunction and treatment strategies for stable coronary artery disease. The Journal of thoracic and cardiovascular surgery. 2009 Jun; 137(6):1443-9. doi: 10.1016/j.jtcvs.2008.11.028.

Azarbal A, Malenka DJ, Huang YL, Ross CS, Solomon RJ, DeVries JT, et al. Recovery of Kidney Dysfunction After Transcatheter Aortic Valve Implantation (from the Northern New England Cardiovascular Disease Study Group). The American Journal of Cardiology. 2019 Feb; 123(3):426-433. doi: 10.1016/j.amjcard.2018.10.042.

Levin A, Djurdjev O, Barrett B, Burgess E, Carlisle E, Ethier J, et al. Cardiovascular disease in patients with chronic kidney disease: getting to the heart of the matter. American journal of kidney diseases. 2001 Dec; 38(6):1398-407. doi: 10.1053/ajkd.2001.29275.

Cirillo M, Lanti MP, Menotti A, Laurenzi M, Mancini M, Zanchetti A, et al. Definition of kidney dysfunction as a cardiovascular risk factor: use of urinary albumin excretion and estimated glomerular filtration rate. Archives of internal medicine. 2008 Mar; 168(6):617-24. doi: 10.1001/archinte.168.6.617.

Chonchol M, Cigolini M, Targher G. Association between 25-hydroxyvitamin D deficiency and cardiovascular disease in type 2 diabetic patients with mild kidney dysfunction. Nephrol Dial Transplant. 2008 Jan ;23(1):269-74. doi: 10.1093/ndt/gfm537.

Schefold JC, Filippatos G, Hasenfuss G, Anker SD, von Haehling S. Heart failure and kidney dysfunction: epidemiology, mechanisms and management. Nature Reviews Nephrology. 2016 Oct; 12(10):610-23. doi: 10.1038/nrneph.2016.113.

Wall BM, Hardison RM, Molitch ME, Marroquin OC, McGill JB, August PA; BARI 2D Study Group. High prevalence and diversity of kidney dysfunction in patients with type 2 diabetes mellitus and coronary artery disease: the BARI 2D baseline data. The American journal of the medical sciences. 2010 May; 339(5):401-10. doi: 10.1097/MAJ.0b013e3181d430ad.

Deferrari G, Cipriani A, La Porta E. Renal dysfunction in cardiovascular diseases and its consequences. Journal of Nephrology. 2021 Feb;34(1):137-153. doi: 10.1007/s40620-020-00842-w.

Knight EL, Rimm EB, Pai JK, Rexrode KM, Cannuscio CC, Manson JE, et al. Kidney dysfunction, inflammation, and coronary events: a prospective study. Journal of the American Society of Nephrology. 2004 Jul; 15(7):1897-903. doi: 10.1097/01.asn.0000128966.55133.69.

Nakayama M, Metoki H, Terawaki H, Ohkubo T, Kikuya M, Sato T, et al. Kidney dysfunction as a risk factor for first symptomatic stroke events in a general Japanese population--the Ohasama study. Nephrology Dialysis Transplantation. 2007 Jul; 22(7):1910-5. doi: 10.1093/ndt/gfm051.

Moisi MI, Rus M, Bungau S, Zaha DC, Uivarosan D, Fratila O, et al. Acute Coronary Syndromes in Chronic Kidney Disease: Clinical and Therapeutic Characteristics. Medicina (Kaunas). 2020 Mar; 56(3):118. doi: 10.3390/medicina56030118.

Dohi T, Kasai T, Miyauchi K, Takasu K, Kajimoto K, Kubota N, et al. Prognostic impact of chronic kidney disease on 10-year clinical outcomes among patients with acute coronary syndrome. Journal of Cardiology. 2012 Dec; 60(6):438-42. doi: 10.1016/j.jjcc.2012.08.007.

Zaliūnas R, Slapikas R, Luksiene D, Slapikiene B, Statkeviciene A, Milvidaite I, et al. Metabolinio sindromo komponentu daznis tarp susirgusiuju ūminiais iseminiais sindromais [Prevalence of metabolic syndrome components in patients with acute coronary syndromes]. Medicina (Kaunas). 2008; 44(3):182-8. doi.org/10.3390/medicina44030023

Hawranek M, Gierlotka M, Gąsior M, Hudzik B, Desperak P, Ciślak A, et al. Renal function on admission affects both treatment strategy and long-term outcomes of patients with myocardial infarction (from the Polish Registry of Acute Coronary Syndromes). Kardiologia Polska (Polish Heart Journal). 2017 Jan;75(4):332-343. doi: 10.5603/KP. a2017.0013.

Homorodean C, Iancu AC, Dregoesc IM, Spînu M, Ober MC, Tãtaru D, et al. Renal Failure Impact on the Outcomes of ST-Segment Elevation Myocardial Infarction Patients Due to a Left Main Coronary Culprit Lesion Treated Using a Primary Percutaneous Coronary Intervention. Journal of Clinical Medicine. 2019 Apr 25;8(4):565. doi: 10.3390/jcm8040565.

Wańha W, Kawecki D, Roleder T, Pluta A, Marcinkiewicz K, Morawiec B, et al. Long-Term Percutaneous Coronary Intervention Outcomes of Patients with Chronic Kidney Disease in the Era of Second-Generation Drug-Eluting Stents. Cardiorenal Medicine. 2017 Feb; 7(2):85-95. doi: 10.1159/000452745.

Petronijevic Z, Selim G, Petkovska L, Georgievska-Ismail L, Spasovski G, Tozija L. The Effect of Treatment on Short-Term Outcomes in Elderly Patients with Acute Kidney Injury. Open access Macedonian journal of medical sciences. 2017 Aug 9;5(5):635-640. doi: 10.3889/oamjms.2017.148.

Matějka J, Varvařovský I, Rozsíval V, Herman A, Bláha K, Večeřa J, et al. Heart failure is the strongest predictor of acute kidney injury in patients undergoing primary percutaneous coronary intervention for ST-elevation myocardial infarction. Kardiologia Polska (Polish Heart Journal). 2016; 74(1):18-24. doi: 10.5603/KP. a2015.0115.

Hamzic-Mehmedbasic A, Rebic D, Balavac M, Muslimovic A, Dzemidzic J. Clinical analysis of etiology, risk factors and outcome in patients with acute kidney injury. Materia socio-medica. 2015 Apr;27(2):70-4. doi: 10.5455/msm.2015.27.71-74.