Assessment Of Frequency of EEG Findings in Children with Epilepsy in A Tertiary Care Hospital in Karachi, Pakistan

Frequency of EEG Findings in Children With Epilepsy

Authors

  • Faiqa Hassan Memon Medical Institute Hospital Karachi
  • Shazia Ali Shaheed Nawab Ghos Bakhash Raisani Memorial Hospital Mastung
  • Misbah Munir Mekran Medical College, Teaching Hospital Turbat
  • Ali Masood Memon Medical Institute Hospital
  • Munazza Suharwardy Obaid Dow Hospital Karachi
  • Ramsha Urooj Baig Dow university of Health sciences Karachi
  • Faiza Zakaria Dow university of Health sciences Karachi

DOI:

https://doi.org/10.54393/pbmj.v5i6.565

Keywords:

Epilepsy, Arrythmias, EEG, Inter-ictal epileptic discharge, Focal epilepsy

Abstract

Epilepsy impacts around 46 million individuals worldwide, with an exacerbated incidence and mortality in lower-income settings Objective: To evaluate the use of EEG in determining the diagnosis of epilepsy, with its particular subtypes. This study also assessed the vital correlation between age and sex with subnormal EEG findings. Methods: It is a cross-sectional study conducted at MMI Pead’s Memon Hospital, Karachi, from January 2020 to December 2020. Age ranges between 1 month and 18 years. Study evaluated the correlation of EEG findings. The EEG patterns was also assessed. EEG patterns were categorized as normal, abnormal with either background slowing or interictal epileptiform discharges (IED) or both, types of seizure and day of admission when the EEG was performed. Using SPSS latest version, association of age, and sex with abnormal EEGs was determined Results: Two-third of the children reported normal EEG, whereas abnormal background findings were observed in the remaining one-third. Inter- ictal epileptic discharge was noted on 18 EEG reports. This finding was most frequent in children within the age bracket of 30 months to more than 67 months. A combination of inter-ictal epileptic discharge and abnormal background findings were noted in children older than 49 months. However, hypsarrhythmia was noted in 2 subjects, both under 30 months of age. With regards to diagnosis, majority of the children categorized as having generalized epilepsy were over 67 months of age. Focal epilepsy was the second most frequent diagnosis, with majority under 30 months of age. On the association of EEG findings with sex, out findings were insignificant. Conclusions: EEG has been determined as the investigation of choice among patients with epilepsy, however it may have certain limitations in providing an accurate diagnosis, and must not be relied on as the sole determinant of epilepsy.

References

Sirven JI. Cold Spring Harbor Perspectives in Medicine. 2015,5. doi:10.1101/cshperspect.a022848

Milligan TA. Epilepsy: A clinical overview. The American Journal of Medicine,2021, 134(7), 840–847. doi:10.1016/j.amjmed.2021.01.038

GBD 2016 Epilepsy Collaborators. Global, regional, and national burden of epilepsy, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016. Lancet Neurology, 2019,18(4), 357–375. doi:10.1016/S1474-4422(18)30454-X

England MJ, Liverman CT, Schultz AM & Strawbridge LM. Epilepsy across the spectrum: promoting health and understanding. A summary of the Institute of Medicine report. Epilepsy & Behavior: E&B, 2012,25(2), 266–276. doi:10.1016/j.yebeh.2012.06.016

Khatri IA, Iannaccone ST, Ilyas MS, Abdullah M & Saleem S. Epidemiology of epilepsy in Pakistan: review of literature. JPMA. The Journal of the Pakistan Medical Association, 2003,53(12), 594–597.

Chen H & Koubeissi MZ. Electroencephalography in epilepsy evaluation. Continuum (Minneapolis, Minn.), 2019,25(2), 431–453. doi:10.1212/CON.0000000000000705

Rana KS. Rational use of EEG in childhood epilepsy. Indian Journal of Pediatrics, 2000,67(1 Suppl), S22-31.

Eze CO, Afolabi OF et al. Electroencephalography: Experience at Abakaliki Nigeria. 2021, 13(9): 1-71.

Sillanpää M & Helen Cross J. The psychosocial impact of epilepsy in childhood. Epilepsy & Behavior: E&B,2009, 15 Suppl 1(2), S5-10. doi:10.1016/j.yebeh.2009.03.007

Asadi-Pooya AA & Homayoun M. Sex differences in characteristics of idiopathic generalized epilepsies. Neurological Sciences: Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2021,42(6), 2421–2424. doi:10.1007/s10072-020-04834-3

Bihege CJ, Langer T, Jenke ACW, Bast T & Borusiak P. Prevalence of epileptiform discharges in healthy infants. Journal of Child Neurology, 2015,30(11), 1409–1413. doi:10.1177/0883073814565457

Chen H and Koubeissi MZ. Electroencephalography in Epilepsy Evaluation. Continuum (Minneap Minn). 2019 Apr;25(2):431-453. doi: 10.1212/CON.0000000000000705.

Hani AJ. T20. EEG characteristics affecting response to therapy in selected patients with infantile spasms and hypsarrhythmia. Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology, 2018,129, e9. doi:10.1016/j.clinph.2018.04.021

Beghi EJN. The epidemiology of epilepsy. 2020, 54(2): 185-191.

Stafstrom CE and Carmant L. Seizures and epilepsy: an overview for neuroscientists. Cold Spring Harbor perspectives in medicine, 2015, 5(6): a022426.

. Falco-Walter JJ, Scheffer IE et al. The new definition and classification of seizures and epilepsy. Epilepsy research, 2018, 139: 73-79.

Das JC. Electroencephalogram (EEG) in the management of epilepsy in children. Mymensingh Medical Journal: MMJ, 2014,23(2), 406–411.

Doose H & Sitepu B. Childhood epilepsy in a German city. Neuropediatrics, 1983, 14(4), 220–224. doi:10.1055/s-2008-1059582

Smith SJM. EEG in the diagnosis, classification, and management of patients with epilepsy. Journal of Neurology, Neurosurgery, and Psychiatry, 2005,76 Suppl 2(suppl_2), ii2-7. doi:10.1136/jnnp.2005.069245

Seneviratne U, Cook MJ et al. Electroencephalography in the Diagnosis of Genetic Generalized Epilepsy Syndromes. Frontiers in Neurology, 2017,8: 499-499

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Published

2022-06-30
CITATION
DOI: 10.54393/pbmj.v5i6.565
Published: 2022-06-30

How to Cite

Hassan, F. ., Ali , S. ., Munir, M. ., Masood, A. ., Suharwardy Obaid, M. ., Urooj Baig, R. ., & Zakaria, F. . (2022). Assessment Of Frequency of EEG Findings in Children with Epilepsy in A Tertiary Care Hospital in Karachi, Pakistan: Frequency of EEG Findings in Children With Epilepsy. Pakistan BioMedical Journal, 5(6), 258–261. https://doi.org/10.54393/pbmj.v5i6.565

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