Recent Progress on Carotenoids Production from Microalgae: A review

Progress in Carotenoids Production from Microalgae

Authors

  • Mariam Waseem Department of Biotechnology, Kinnaird College for Women, Lahore, Pakistan

DOI:

https://doi.org/10.54393/pbmj.v5i10.811

Keywords:

Carotenoids, Microalgae, Lipochromes, Food colorant, β-carotene

Abstract

The color of fruits and green vegetables is attributed to a pigment known as carotenoids. On the basis of presence and absence of oxygen, carotenoids are divided into two categories; carotenes which do not contain oxygen and xanthophylls which are oxygen carrier. Carotenoids are not only good anti-oxidant agents; they also exhibit anti-tumor properties. The structure of carotenoids consists of eight isoprene units, which forms a chain consisting of conjugated double bonds. The presence of conjugated double bond in carotenoids neutralize free radicals by accepting electrons from them. Till now, most of the carotenoids commercially available are produced chemically however, microalgae are a good source of carotenoids. Microalgae can produce the carotenoids in abundance using two-stage cultivation strategies. In first phase, microalgae are given with optimal growth conditions for maximum production of biomass, on the other hand, keeping the second phase for the storage of lipids or carotenoids in unfavorable conditions. The production of carotenoids in two-stage approach is increased by many times than the conventional single phase cultivation method. Carotenoids have many industrial applications.

References

Park SC, Kim SH, Park S, Lee HU, Lee JS, Park WS, et al. Enhanced accumulation of carotenoids in sweet potato plants overexpressing IbOr-Ins gene in purple-fleshed sweet potato cultivar. Plant Physiology and Biochemistry. 2015 Jan; 86:82-90. doi: 10.1016/j.plaphy.2014.11.017.

Britton G, Liaaen-Jensen S, Pfander H. Carotenoids: a colourful history. Carote Nature. 2017.

Zheng X, Giuliano G, Al-Babili S. Carotenoid biofortification in crop plants: citius, altius, fortius. Biochimica et Biophysica Acta (BBA)-Molecular and Cell Biology of Lipids. 2020 Nov; 1865(11):158664. doi: 10.1016/j.bbalip.2020.158664.

Rodriguez-Concepcion M, Avalos J, Bonet ML, Boronat A, Gomez-Gomez L, Hornero-Mendez D, et al. A global perspective on carotenoids: Metabolism, biotechnology, and benefits for nutrition and health. Progress in Lipid Research. 2018 Apr; 70:62-93. doi: 10.1016/j.plipres.2018.04.004.

Yuan H, Zhang J, Nageswaran D, Li L. Carotenoid metabolism and regulation in horticultural crops. Horticulture Research. 2015 Aug; 2:15036. doi: 10.1038/hortres.2015.36

Giuliano G, Al-Babili S, von Lintig J. Carotenoid oxygenases: cleave it or leave it. Trends in Plant Sciences. 2003 Apr; 8(4):145-9. doi: 10.1016/S1360-1385(03)00053-0.

Sasso S, Pohnert G, Lohr M, Mittag M, Hertweck C. Microalgae in the postgenomic era: a blooming reservoir for new natural products. FEMS Microbiology Reviews. 2012 Jul; 36(4):761-85. doi: 10.1111/j.1574-6976.2011.00304.x.

Saini RK and Keum YS. Progress in Microbial Carotenoids Production. Indian Journal of Microbiology. 2017 Mar; 57(1):129-130. doi: 10.1007/s12088-016-0637-x.

Varela JC, Pereira H, Vila M, León R. Production of carotenoids by microalgae: achievements and challenges. Photosynthesis Research. 2015 Sep; 125(3):423-36. doi: 10.1007/s11120-015-0149-2.

Eggersdorfer M and Wyss A. Carotenoids in human nutrition and health. Archives of Biochemistry and Biophysics. 2018 Aug; 652:18-26. doi: 10.1016/j.abb.2018.06.001.

Fiedor J and Burda K. Potential role of carotenoids as antioxidants in human health and disease. Nutrients. 2014 Jan; 6(2):466-88. doi: 10.3390/nu6020466.

Nunes M, Vieira AAH, Pinto E, Carneiro RL, Monteiro AC. Carotenogênese em células de Haematococcus pluvialis induzidas pelos estresses luminoso e nutricional. Pesquisa Agropecuária Brasileira. 2013 Aug; 48:825-832. doi: 10.1590/S0100-204X201300080

Safafar H, van Wagenen J, Møller P, Jacobsen C. Carotenoids, Phenolic Compounds and Tocopherols Contribute to the Antioxidative Properties of Some Microalgae Species Grown on Industrial Wastewater. Marine Drugs. 2015 Dec; 13(12):7339-56. doi: 10.3390/md13127069.

Henríquez V, Escobar C, Galarza J, Gimpel J. Carotenoids in Microalgae. Subcellular Biochemistry. 2016 Aug; 79:219-37. doi: 10.1007/978-3-319-39126-7_8.

Borowitzka MA. High-value products from microalgae—their development and commercialisation. Journal of applied phsycology. 2013 Jan; 25(3), 743-756. doi: 10.1007/s10811-013-9983-9

Minhas AK, Hodgson P, Barrow CJ, Adholeya A. A review on the assessment of stress conditions for simultaneous production of microalgal lipids and carotenoids. Frontiers in microbiology. 2016 May; 7:546. doi: 10.3389/fmicb.2016.00546

Meléndez‐Martínez AJ. (2019). An overview of carotenoids, apocarotenoids, and vitamin A in agro‐food, nutrition, health, and disease. Molecular nutrition & food research. 2019 Aug; 63(15):e1801045. doi: 10.1002/mnfr.201801045.

Young AJ and Lowe GL. Carotenoids-Antioxidant Properties. Antioxidants (Basel). 2018 Feb; 7(2):28. doi: 10.3390/antiox7020028.

Donhowe EG and Kong F. Beta-carotene: digestion, microencapsulation, and in vitro bioavailability. Food and Bioprocess Technology. 2014 Mar; 7(2), 338-354.

Rinninella E, Mele MC, Merendino N, Cintoni M, Anselmi G, Caporossi A, et al. The Role of Diet, Micronutrients and the Gut Microbiota in Age-Related Macular Degeneration: New Perspectives from the Gut⁻Retina Axis. Nutrients. 2018 Nov; 10(11):1677. doi: 10.3390/nu10111677.

Rodriguez-Amaya, D. B. (2015a). Food carotenoids: chemistry, biology and technology: John Wiley & Sons. 2015 Nov.

Campestrini LH, Melo PS, Peres LEP, Calhelha RC, Ferreira ICFR, Alencar SM. A new variety of purple tomato as a rich source of bioactive carotenoids and its potential health benefits. Heliyon. 2019 Nov; 5(11):e02831. doi: 10.1016/j.heliyon.2019.e02831.

Barreiro C and Barredo JL. Carotenoids Production: A Healthy and Profitable Industry. Methods in Molecular Biology. 2018 Aug; 1852:45-55. doi: 10.1007/978-1-4939-8742-9_2.

Saini RK, Nile SH, Park SW. Carotenoids from fruits and vegetables: Chemistry, analysis, occurrence, bioavailability and biological activities. Food Research International. 2015 Oct; 76(3):735-750. doi: 10.1016/j.foodres.2015.07.047.

Merhan, O. The biochemistry and antioxidant properties of carotenoids. Carotenoids. 2015 Sep; 5:51. doi: 10.5772/67592

Rutz JK, Borges CD, Zambiazi RC, da Rosa CG, da Silva MM. Elaboration of microparticles of carotenoids from natural and synthetic sources for applications in food. Food Chemistry. 2016 Jul; 202:324-33. doi: 10.1016/j.foodchem.2016.01.140.

Long SP, Marshall-Colon A, Zhu XG. Meeting the global food demand of the future by engineering crop photosynthesis and yield potential. Cell. 2015 Mar;161(1):56-66. doi: 10.1016/j.cell.2015.03.019.

Zakynthinos G and Varzakas T. Carotenoids: From plants to food industry. Current Research in Nutrition and Food Science. 2016 Apr; 4(Special Issue), 38. doi: 10.12944/CRNFSJ.4.Special-Issue1.04

Harrison EH, Curley RW Jr. Carotenoids and Retinoids: Nomenclature, Chemistry, and Analysis. Subcellular Biochemistry. 2016 Jan; 81:1-19. doi: 10.1007/978-94-024-0945-1_1.

Pangestuti R, Siahaan EA, Kim SK. Photoprotective Substances Derived from Marine Algae. Marine Drugs. 2018 Oct; 16(11):399. doi: 10.3390/md16110399.

Onwude D, Hashim N, Janius R, Nawi N, Abdan K. Color change kinetics and total carotenoid content of pumpkin as affected by drying temperature. Italian Journal of Food Science. 2017 Sep; 29(1):1. doi: 10.14674/1120-1770/ijfs.v398

Bechoff A, Chijioke U, Tomlins KI, Govinden P, Ilona P, Westby A, et al. (2015). Carotenoid stability during storage of yellow gari made from biofortified cassava or with palm oil. Journal of Food Composition and Analysis. 2015 Dec; 44:36-44. doi: 10.1016/j.jfca.2015.06.002

Rizwan M, Mujtaba G, Memon SA, Lee K, Rashid N. (2018). Exploring the potential of microalgae for new biotechnology applications and beyond: a review. Renewable and Sustainable Energy Reviews. 2018 May; 92:394-404. doi: 10.1016/j.rser.2018.04.034

Radakovits R, Jinkerson RE, Fuerstenberg SI, Tae H, Settlage RE, Boore JL, et al. Draft genome sequence and genetic transformation of the oleaginous alga Nannochloropis gaditana. Nature Communications. 2012 Feb; 3:686. doi: 10.1038/ncomms1688.

Rauytanapanit M, Janchot K, Kusolkumbot P, Sirisattha S, Waditee-Sirisattha R, Praneenararat T. Nutrient Deprivation-Associated Changes in Green Microalga Coelastrum sp. TISTR 9501RE Enhanced Potent Antioxidant Carotenoids. Marine Drugs. 2019 Jun; 17(6):328. doi: 10.3390/md17060328.

Hosseini SRP, Tavakoli O, Sarrafzadeh MH. Experimental optimization of SC-CO2 extraction of carotenoids from Dunaliella salina. The Journal of Supercritical Fluids. 2017 Jan; 121, 89-95. doi: 10.1016/j.supflu.2016.11.006

Ng IS, Tan SI, Kao PH, Chang YK, Chang JS. Recent Developments on Genetic Engineering of Microalgae for Biofuels and Bio-Based Chemicals. Biotechnology Journal. 2017 Oct; 12(10):1600644. doi: 10.1002/biot.201600644.

Rodrigues DB, Flores ÉM, Barin JS, Mercadante AZ, Jacob-Lopes E, Zepka LQ. Production of carotenoids from microalgae cultivated using agroindustrial wastes. Food Research International. 2014 Nov; 65:144-148. doi: 10.1016/j.foodres.2014.06.037

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Published

2022-10-31
CITATION
DOI: 10.54393/pbmj.v5i10.811
Published: 2022-10-31

How to Cite

Waseem, M. . (2022). Recent Progress on Carotenoids Production from Microalgae: A review : Progress in Carotenoids Production from Microalgae. Pakistan BioMedical Journal, 5(10), 14–18. https://doi.org/10.54393/pbmj.v5i10.811

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