Evaluation OF Novel Hormone Asprosin And Its Role In Insulin Resistance In Neonatal Cord Blood Of Preeclamptic And Healthy Pregnant Mothers: Novel Hormone Asprosin And Its Role In Insulin Resistance In Neonatal Cord Blood

Nida Shafi; Rehana  Mushtaq; Farhat  Bano

doi:10.54393/pbmj.v4i2.94

Authors

Nida Shafi Department of Biochemistry, University of Health Science Lahore, Punjab, Pakistan
Rehana Mushtaq Obs & Gynae Department, National Medical College and Teaching Hospital, Parsa, Birgunj, Nepal
Farhat Bano Department of Biochemistry, University of Health Science Lahore, Punjab, Pakistan

DOI:

https://doi.org/10.54393/pbmj.v4i2.94

Keywords:

Preeclampsia, insulin resistance, asprosin, insulin, HOMA-IR, Agouti-related protein (AgRP)

Abstract

Asprosin, a novel glucogenic adipokine, plays a complex role in central nervous tissue, peripheral tissues and other organs. It is involved in glucose metabolism, appetite, insulin resistance, cell apoptosis etc. This study aimed to find relationship between asprosin and other insulin resistance related-hormones in neonates of preeclamptic mothers. A comparative cross-sectional study was conducted on 42 neonates of preeclamptic pregnant mothers and 42 neonates of healthy pregnant mothers. Samples were taken from placentas at the time of delivery and were processed for estimation of asprosin, insulin, C-peptide and glucose hormones. Data was analysed using SPSS 21. Normality of the data was checked and Independent t-test was applied. A p-value of ≤0.05 was considered significant. P-values of asprosin, insulin, C-peptide, glucose and HOMA-IR index were 0.020, 0.550, 0.360, 0.310 and 0.740, respectively when compared between neonates of preeclamptic pregnant mothers and healthy pregnant mothers.

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