Molecular Insight of Mangiferin in Cancer Chemoprevention: A Review Article: Molecular Insight of Mangiferin in Cancer Chemoprevention

Muhammad Ateeb; Muhammad Subhan Nazar; Shahbaz Ahmad Zakki; Asim Raza; Ussama Hafeez

doi:10.54393/pbmj.v9i3.1342

Authors

Muhammad Ateeb Department of Research Innovation and Commercialization, The University of Faisalabad, Faisalabad, Pakistan
Muhammad Subhan Nazar Department of Public Administration, Gomal University, Dera Ismail Khan, Pakistan
Shahbaz Ahmad Zakki Department of Public Health, The University of Haripur, Haripur, Pakistan
Asim Raza Department of Public Health, The University of Haripur, Haripur, Pakistan
Ussama Hafeez Department of Public Health, The University of Haripur, Haripur, Pakistan

DOI:

https://doi.org/10.54393/pbmj.v9i3.1342

Keywords:

Mangiferin, Chemopreventive, Antioxidant, Chemotherapeutic, Cancer Medicine, Anti-angiogenesis, Anti-VEGF

Abstract

Cancer is a public health problem causing one in six deaths globally. Fighting cancer has always been challenging, leading to an evolution in cancer therapies. Mangiferin, a bioactive component found in honeybush tea and mangoes, is a chemotherapeutic and chemopreventive drug against many cancers. This review addresses the critical need for alternative and cost-effective cancer treatments in developing countries, which bear 57% of new cancer cases and 65% of cancer-related deaths globally. A non-systematic search was conducted using research engines such as MEDLINE, Scopus, PMC, Embase, PubMed, Web of Science, and Google Scholar. More than 250 studies have been carried out on Mangiferin between 2001 and 2021, including clinical trials for cancer treatment. Mangiferin demonstrates significant anticancer activity by suppressing malignant proliferation across multiple cancer cell lines, including CCD-18Co, LNCaP, MCF-7, OVCAR3, HeLa, HepG2, MDA-MB-231, A549, and others. The compound targets diverse molecular pathways involved in proliferation, apoptosis evasion, metastasis, and angiogenesis, including NF-kB, MMPs, COX-2, FGF, VEGF, and ICAM. Additionally, Mangiferin exhibits chemopreventive properties and synergizes with conventional anticancer agents. However, its clinical translation is hindered by poor oral bioavailability (<2%), necessitating advanced drug delivery strategies due to its synergistic effect with other anticancer drugs. This review highlights the manifold anti-cancer benefits of Mangiferin and proposes a robust methodology for validating animal studies through quantitative and qualitative analyses. These findings offer valuable insights for researchers to investigate the diverse pharmacological properties of Mangiferin in cancer, paving the way for promising avenues in cancer chemoprevention.

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