Correlation of Red Blood Cell Distribution Width with The Severity of Coronary Artery Disease

Red Blood Cell Distribution Width With The Severity Of Coronary Artery Disease

Authors

  • Mohsin Shabir Department of Cardiology, Rehman Medical Institute, Peshawar, Pakistan
  • Ikram ul Haq Department of medicine Letterkenny University Hospital, Ireland
  • Muhammad Kashif Iltaf Department of Cardiology, Qazi Hussain Ahmad Medical Complex, Nowshera
  • Ahsan Shabir Department of Cardiac Anesthesia, Rehman Medical Institute, Peshawar, Pakistan
  • Muhammad Shehram Department of Cardiology, Armed Forces Institute Of Cardiology, Rawalpindi, Pakistan
  • Naseer Ahmed Department of medicine, Rehman medical institute, Peshawar, Pakistan

DOI:

https://doi.org/10.54393/pbmj.v5i4.420

Keywords:

Modified Genisi Score(MGS), Coronary Artery Disease(CAD),Red Cell Distribution Width (RDW),Anemia

Abstract

Atherosclerosis causing occlusion of coronary vessels by building up of plaque leading to narrowing of vessels supplying heart and causing coronary artery disease, which is the leading and common cause of mortality around the globe. Objective:   To find the correlation of Red Cell Distribution Width (RDW) and severity of Coronary Artery Disease (CAD) lesions Methods:  A number of   280 patients in total, admitted to cardiology department who presented with chest pain and diagnosed as angina, positive treadmill test and who underwent angiography and were found to have CAD, were enrolled in the study over a period of one year. Modified Gensini score (MGS) is used for assessment of severity of CAD. Each patient was assessed in relation to severity of CAD using MGS scoring system. Results: Out of 280 patients, 218 were assigned to Group A and 70 were assigned to Group B. Mean age of presentation were (52.34± 13.90 vs 50.8± 11.63 years). Male subjects were predominant overall with ratio of 2.63:1. RDW was assessed and was seen to be significantly elevated in Group A in comparison to Group B (14.98± 1.59 vs 13.82 ± 0.91p= <0.0001). After assessing MGS in relation to severity of CAD, significant correlation was observed. RDW was found to be increasing as MGS score increased (14.46± 0.65 vs 14.98± 1.00 vs 15.02± 0.88, p= <0.0001) Conclusions: It was concluded that RDW is a parameter which is cost effective, very easy, readily and urgently available for the assessment and stratification of patients presenting with coronary artery disease.

References

Cardiovascular diseases (CVDs) (who.int)

Perkins SL. Examination of blood and bone marrow. In: Greer JP, Foerester J, Lukens JN, Rodgers GM, Paraksevas F, Glader BE, eds. Wintrobe’s Clinical Hematology. 11th ed. Salt Lake City: Utah: Lippincott Wilkins & Williams; 2003:5–25.

Tonelli M, Sacks F, Arnold M, Moye L, Davis B, Pfeffer M. For the Cholesterol and Recurrent Events (CARE) Trial Investigators. Relation Between Red Blood Cell Distribution Width and Cardiovascular Event Rate in People With Coronary Disease. Circulation. 2008 Jan 15;117(2):163-168. doi: 10.1161/CIRCULATIONAHA.107.727545.

Allen LA, Felker GM, Mehra MR, Chiong JR, Dunlap SH, Ghali JK et al. Validation and potential mechanisms of red cell distribution width as a prognostic marker in heart failure. J Card Fail. 2010 Mar;16(3):230-8. doi: 10.1016/j.cardfail.2009.11.003.

Beutler, Ernest, and Jill Waalen. The definition of anemia: what is the lower limit of normal of the blood hemoglobin concentration?. Blood vol. 107,5 (2006): 1747-50. doi:10.1182/blood-2005-07-3046

Tuttolomondo A, Di Raimondo D, Pecoraro R, Arnao V, Pinto A, Licata G. Atherosclerosis is an inflammatory disease. Curr Pharm Des. 2012;18 (28):4266–4268.

Heyman S, Hirsch E, Anker SD, et al. Inflammation as a therapeutic target in heart failure: a scientific statement from the Translational Research Committee of the Heart Failure Association of the European Society of Cardiology. Eur J Heart Fail. 2009;11:119–129.

Berliner JA, Navab M, Fogelman AM, et al. Atherosclerosis basic mechanism. Oxidation, inflammation and genetics. Circulation. 1995;91:2488–2496.

Heyman S, Hirsch E, Anker SD. Inflammation as a therapeutic target in heart failure: a scientific statement from the Translational Research Committee of the Heart Failure Association of the European Society of Cardiology. Eur J Heart Fail. 2009;11:119–129

Merle U, Fein E, Gehrke SG, Stremmel W, Kulaksiz H. The iron regulatory peptide hepcidin is expressed in the heart and regulated by hypoxia and inflammation. Endocrinology. 2007;148:2663–2668.

Bujak K, J. Wasilewski, T. Osadnik, et al. The Prognostic role of Red blood cell distribution width in coronary artery disease: a review of pathophysiology Disease Markers. Hindawi Publishing Corporation; 2015 .

Yusuf S, Hawken S, Ounpuu S, Dans T, Avezum A, Lanas F, et al. INTERHEART Study Investigators. Effect of potentially modifiable risk factors associated with myocardial infarction in 52 countries (the INTERHEART study): case-control study. Lancet. 2004;364:937–5

Cavusoglu E, Chopra V, Gupta A, et al. Relation between red blood cell distribution width (RDW) and all cause mortality at two years in an unselected population referred for coronary angiography. Int J Cardiol. 2010;141(2):141– 146.

Lippi G, Filippozzi L, Montagnana M, et al. Clinical usefulness of measuring red blood cell distribution width on admission in patients with acute coronary syndromes. Clin Chem Lab Med. 2009;47(3):353–357.

Tenekecioglu E, Yilmaz M, Can Yontar Osman, et al. Red blood cell distribution width is associated with myocardial injury in non ST elevation acute coronary syndrome. Clinics. 2015;70(1):18–23

Dabbah S, Hammerman H, Markiewicz W, Aronson D. Relation between red cell distribution width and clinical outcomes after acute myocardial infarction. Am J Cardiol. 2010 Feb 1;105(3):312-7. doi: 10.1016/j.amjcard.2009.09.027.

Nabais S, Losa N, Gaspar A, Rocha S, Costa J, Azevedo P et al. Association between red blood cell distribution width and outcomes at six months in patients with acute coronary syndromes. Rev Port Cardiol. 2009 Sep;28(9):905-24. English, Portuguese.

Celis R, Torre-Martinez G, Torre-Amione G. Evidence for activation of immune system in heart failure: is there a role for anti-inflammatory therapy? Curr Opin Cardiol. 2008 May;23(3):254-60. doi: 10.1097/HCO.0b013e3282fbfbc7.

Hofmann U, Frantz S. How can we cure a heart "in flame"? A translational view on inflammation in heart failure. Basic Res Cardiol. 2013 Jul;108(4):356. doi: 10.1007/s00395-013-0356-y.

Parizadeh SM, Jafarzadeh-Esfehani R, Bahreyni A, Ghandehari M, Shafiee M, Rahmani F et al. The diagnostic and prognostic value of red cell distribution width in cardiovascular disease; current status and prospective. Biofactors. 2019 Jul;45(4):507-516. doi: 10.1002/biof.1518.

Babes EE, Zaha DC, Tit DM, Nechifor AC, Bungau S, Andronie-Cioara FL et al. Value of Hematological and Coagulation Parameters as Prognostic Factors in Acute Coronary Syndromes. Diagnostics (Basel). 2021 May 9;11(5):850. doi: 10.3390/diagnostics11050850.

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Published

2022-04-30
CITATION
DOI: 10.54393/pbmj.v5i4.420
Published: 2022-04-30

How to Cite

Shabir, M. ., Haq , I. ul ., Iltaf, M. K., Shabir, A. ., Shehram, M. ., & Ahmed, N. . (2022). Correlation of Red Blood Cell Distribution Width with The Severity of Coronary Artery Disease : Red Blood Cell Distribution Width With The Severity Of Coronary Artery Disease. Pakistan BioMedical Journal, 5(4), 252–256. https://doi.org/10.54393/pbmj.v5i4.420

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