Iron deficiency and risk of oral squamous cell carcinoma: Iron expression in oral carcinoma

Imrana  Tanvir; RizwanUllah  Khan; Amber  Hassan; SamiUllah  Mumtaz

doi:10.52229/pbmj.v4i1.53

Authors

Imrana Tanvir Pathology Department, King Abdul Aziz University, Rabigh, Saudi Arabia
RizwanUllah Khan Pathology Department, Prince Faisal Cancer Center, King Fahad Specialist Hospital, Buraidah, Saudi Arabia
Amber Hassan Research Unit, Faculty of Allied Health Sciences, The University of Lahore, Lahore, Pakistan
SamiUllah Mumtaz North Medical Ward, King Edward Medical University/ Mayo hospital, Lahore, Pakistan

DOI:

https://doi.org/10.52229/pbmj.v4i1.53

Abstract

Oral squamous cell carcinoma (OSCC) is a subset of head and neck squamous cell carcinoma caused by excessive substance abuse like alcohol, tobacco etc. Objectives:Aim of the present study was to evaluate the iron expression in different grades of OSCC and potential of iron staining as a prognostic marker and its importance as an essential nutrient in diet.Methods and Patients:It was a cross sectional study.A total of 40 oral biopsies were evaluated and the mean age of patients was 53.5 years with age range 23-80 years. 14 cases were well differentiated, 14 moderately differentiated and there were 12 poorly differentiated case. Iron staining was performed for all these cases. Results:Iron positivity was observed in 11 (27.5%) of OSCC patients with maximum iron positivity in well differentiated group (64.28%) of age range 20-40 years (70%). More patients had tongue as site of cancer. There was no genderwise difference in iron expression. Iron deficiency was associated with poor prognosis indicating iron as an important nutrient which can prevent OSCC if adequately present in our routine diet. Conclusions:Prevalence of iron positivity in young patients and initial stage of OSCC, indicates the protective effect of iron against oral squamous cell carcinoma

References

Allen, C. T., Law, J. H., Dunn, G. P., & Uppaluri, R. (2013). Emerging insights into head and neck cancer metastasis. [Review]. Head Neck, 35(11), 1669-1678. doi: 10.1002/hed.23202

Bose, K. S., Gokhale, P. V., Dwivedi, S., & Singh, M. (2013). Quantitative evaluation and correlation of serum glycoconjugates: Protein bound hexoses, sialic acid and fucose in leukoplakia, oral sub mucous fibrosis and oral cancer. J Nat Sci Biol Med, 4(1), 122-125. doi: 10.4103/0976-9668.107275

Diallo, A., Deschasaux, M., Partula, V., Latino-Martel, P., Srour, B., Hercberg, S., . . . Touvier, M. (2016). Dietary iron intake and breast cancer risk: modulation by an antioxidant supplementation. [Clinical Trial]. Oncotarget, 7(48), 79008-79016. doi: 10.18632/oncotarget.12592

Dreyer, J. H., Hauck, F., Oliveira-Silva, M., Barros, M. H., & Niedobitek, G. (2013). Detection of HPV infection in head and neck squamous cell carcinoma: a practical proposal. [Research Support, Non-U.S. Gov't]. Virchows Arch, 462(4), 381-389. doi: 10.1007/s00428-013-1393-5

Hallberg, L., Bengtsson, C., Garby, L., Lennartsson, J., Rossander, L., & Tibblin, E. (1979). An analysis of factors leading to a reduction in iron deficiency in Swedish women. Bull World Health Organ, 57(6), 947-954.

Li, S. Y., Hu, J. A., & Wang, H. M. (2013). Expression of Yes-associated protein 1 gene and protein in oral squamous cell carcinoma. Chin Med J (Engl), 126(4), 655-658.

Ludwig, H., Evstatiev, R., Kornek, G., Aapro, M., Bauernhofer, T., Buxhofer-Ausch, V., . . . Link, H. (2015a). Erratum to: Iron metabolism and iron supplementation in cancer patients. [Published Erratum]. Wien Klin Wochenschr, 127(23-24), 920-921. doi: 10.1007/s00508-015-0893-5

Ludwig, H., Evstatiev, R., Kornek, G., Aapro, M., Bauernhofer, T., Buxhofer-Ausch, V., . . . Link, H. (2015b). Iron metabolism and iron supplementation in cancer patients. [Review]. Wien Klin Wochenschr, 127(23-24), 907-919. doi: 10.1007/s00508-015-0842-3

Macfarlane, G. J., Boyle, P., & Scully, C. (1992). Oral cancer in Scotland: changing incidence and mortality. BMJ, 305(6862), 1121-1123.

Mafi, N., Kadivar, M., Hosseini, N., Ahmadi, S., & Zare-Mirzaie, A. (2012). Head and neck squamous cell carcinoma in Iranian patients and risk factors in young adults: a fifteen-year study. Asian Pac J Cancer Prev, 13(7), 3373-3378.

Mehboob, R., Tanvir, I., Warraich, R. A., Perveen, S., Yasmeen, S., & Ahmad, F. J. (2015). Role of neurotransmitter Substance P in progression of oral squamous cell carcinoma. [Research Support, Non-U.S. Gov't]. Pathol Res Pract, 211(3), 203-207. doi: 10.1016/j.prp.2014.09.016

Munoz, M., Gomez-Ramirez, S., Besser, M., Pavia, J., Gomollon, F., Liumbruno, G. M., . . . Auerbach, M. (2017). Current misconceptions in diagnosis and management of iron deficiency. [Review]. Blood Transfus, 15(5), 422-437. doi: 10.2450/2017.0113-17

Musallam, K. M., & Taher, A. T. (2018). Iron deficiency beyond erythropoiesis: should we be concerned? [Review]. Curr Med Res Opin, 34(1), 81-93. doi: 10.1080/03007995.2017.1394833

Neville, B. W. (2007). Update on current trends in oral and maxillofacial pathology. [Congresses]. Head Neck Pathol, 1(1), 75-80. doi: 10.1007/s12105-007-0007-4

Parkin, D. M., Bray, F., Ferlay, J., & Pisani, P. (2005). Global cancer statistics, 2002. CA Cancer J Clin, 55(2), 74-108.

Stein, J., Connor, S., Virgin, G., Ong, D. E., & Pereyra, L. (2016). Anemia and iron deficiency in gastrointestinal and liver conditions. [Review]. World J Gastroenterol, 22(35), 7908-7925. doi: 10.3748/wjg.v22.i35.7908

Strojan, P., Corry, J., Eisbruch, A., Vermorken, J. B., Mendenhall, W. M., Lee, A. W., . . . Ferlito, A. (2015). Recurrent and second primary squamous cell carcinoma of the head and neck: when and how to reirradiate. [Review]. Head Neck, 37(1), 134-150. doi: 10.1002/hed.23542

Termine, N., Panzarella, V., Falaschini, S., Russo, A., Matranga, D., Lo Muzio, L., & Campisi, G. (2008). HPV in oral squamous cell carcinoma vs head and neck squamous cell carcinoma biopsies: a meta-analysis (1988-2007). [Meta-Analysis

Review]. Ann Oncol, 19(10), 1681-1690. doi: 10.1093/annonc/mdn372

Wilson, M. J., Dekker, J. W. T., Harlaar, J. J., Jeekel, J., Schipperus, M., & Zwaginga, J. J. (2017). The role of preoperative iron deficiency in colorectal cancer patients: prevalence and treatment. Int J Colorectal Dis, 32(11), 1617-1624. doi: 10.1007/s00384-017-2898-1