Therapeutic and Nutritional Effect of clove: A miracle spice
Therapeutic and Nutritional Effect of Clove
Keywords:Clove, essential oil, phytochemical, pharmacological activity
Clove, also known as Syzygium aromaticum (Family Myrtaceace), is the most important and second-most precious spice traded worldwide. Clove is a rich source of nutrients. Eugenol was discovered to exist in clove essential oil as a significant component. An examination of the essential oil's phytochemistry revealed the presence of steroids, glycosides, alkaloids, flavanoids, saponins, and flavonoids. Numerous pharmacological actions, including antihyperlipidemic, antibacterial, antifungal, anticancer, and anti-inflammatory, are present in clove.
Wankhede TB. Evaluation of antioxidant and antimicrobial activity of the Indian clove Syzygium aromaticum L. Merr. and Perr. International Research Journal of Science and Engineering. 2015; 3:166-72.
Shukla V, Mendiratta S, Zende R, Badhe S. Evaluation of the in-vitro antimicrobial activity of clove and oregano essential oils against foodborne microbes and its comparison with antibiotics. The Pharma Innovation Journal. 2022; 11:732-8.
Picanço JMA, Limberger RP, Apel MA. Where should I start? A scoping review about the publications on clove cigarettes. Critical Reviews in Toxicology. 2022 Apr; 52(4):259-293. doi: 10.1080/10408444.2022.2097053
Adebisi AA, Olumide MD, Akintunde AO. Nutritive value and phytochemical screening of turmeric and clove as a potential phyto-additive in livestock production. Nigerian Journal of Animal Science. 2021 Dec; 23(2):142-52.
Soh WK and Parnell J. A revision of Syzygium gaerth (Myrtaceace) in Indochina (Cambodia, Laos and Vietnam). Adansonia. 2015; 37:179-275. doi: 10.5252/a2015n2a1
Kaur K and Kaushal S. Phytochemistry and pharmacological aspects of Syzygium aromaticum: A review. Journal of Pharmacognosy and Phytochemistry. 2019; 8:398-406.
Danthu P, Simanjuntak R, Fawbush F, Tsy JL, Razaϐimamonjison G, Abdillahi MM, et al. The clove tree and its products (clove bud, clove oil, eugenol): prosperous today but what of tomorrow’s restrictions?. World. 2020; 161(58,172):52-915.
ByNg JW, Barthelat F, SNoW N, BerNardINI B. Revision of Eugenia and Syzygium (Myrtaceae) from the Comoros archipelago. Phytotaxa. 2016 Mar; 252(3):163-84. doi: 10.11646/phytotaxa.252.3.1
Kumar V, Mishra D, Joshi MC, Mishra P, Tanwar M. Herbs and Spices—New Processing Technologies. Syzygium aromaticum: Medicinal Properties and Phytochemical Screening. InHerbs and Spices-New Processing Technologies 2021 Nov 2. IntechOpen.
Vitalini S, Orlando F, Iriti M. Selective phytotoxic activity of eugenol towards monocot and dicot target species. Natural Product Research. 2022 Mar; 36(6):1659-1662. doi: 10.1080/14786419.2021.1897810
Parham S and Zargar Kharazi A. Cellulosic textile/clove nanocomposite as an antimicrobial wound dressing: In vitro and in vivo study. Colloidal and Surfaces B Biointerfaces. 2022 Sep; 217:112659. doi: 10.1016/j.colsurfb.2022.112659
Boughendjioua H. Essential oil composition of Syzygium aromaticum (L.). IRJPMS. 2018; 11:26-8.
Alma MH, Ertas M, Nitz S, Kollmannsberger H. Chemical composition and content of essential oil from the bud of cultivated Turkish clove (Syzygium aromaticum L.). BioResources. 2007 May; 2(2):265-9. doi: 10.15376/biores.2.2.265-269
Venkadeswaran K, Muralidharan AR, Annadurai T, Ruban VV, Sundararajan M, Anandhi R, et al. Antihypercholesterolemic and Antioxidative Potential of an Extract of the Plant, Piper betle, and Its Active Constituent, Eugenol, in Triton WR-1339-Induced Hypercholesterolemia in Experimental Rats. Evidence Based Complementary and Alternative Medicine. 2014; 2014:478973. doi: 10.1155/2014/478973
Yan Y, Wang S, Gu J, Min Z, Wang R. Effect of Nano-Oleanolic Acid Combined with Lipid-Lowering Ketones on Insulin Resistance in Rats with Gestational Diabetes. Journal of Biomedicine Nanotechnology. 2022 Feb; 18(2):474-480. doi: 10.1166/jbn.2022.3262
Djeziri FZ, Belarbi M, Murtaza B, Hichami A, Benammar C, Khan NA. Oleanolic acid improves diet-induced obesity by modulating fat preference and inflammation in mice. Biochimie. 2018 Sep; 152:110-120. doi: 10.1016/j.biochi.2018.06.025
Fernández-Aparicio Á, Correa-Rodríguez M, Castellano JM, Schmidt-RioValle J, Perona JS, González-Jiménez E. Potential Molecular Targets of Oleanolic Acid in Insulin Resistance and Underlying Oxidative Stress: A Systematic Review. Antioxidants. 2022 Aug; 11(8):1517. doi: 10.3390/antiox11081517
Su S, Wu G, Cheng X, Fan J, Peng J, Su H, et al. Oleanolic acid attenuates PCBs-induced adiposity and insulin resistance via HNF1b-mediated regulation of redox and PPARγ signaling. Free Radical Biology and Medicine. 2018 Aug; 124:122-34. doi: 10.1016/j.freeradbiomed.2018.06.003.
Pérez-Jiménez A, Rufino-Palomares EE, Fernández-Gallego N, Ortuño-Costela MC, Reyes-Zurita FJ, Peragón J, et al. Target molecules in 3T3-L1 adipocytes differentiation are regulated by maslinic acid, a natural triterpene from Olea europaea. Phytomedicine. 2016 Nov; 23(12):1301-11. doi: 10.1016/j.phymed.2016.07.001.
Gosavi NS, Koli SS, Jire DS, Shaikh AZ. Clove (Syzygium Aromaticum): A Miraculous Spice.
Abdullah BH, Hatem SF, Jumaa W. A comparative study of the antibacterial activity of clove and rosemary essential oils on multidrug resistant bacteria. Pharmaceutical and Biosciences Journal. 2015 Feb 27:18-22. doi: 10.20510/ukjpb/3/i1/89220
Pérez Gutiérrez RM, Arrioja MW. Rapid Model to Evaluate the Anti-Obesity Potential of a Combination of Syzygium aromaticum (Clove) and Cuminun cyminum (Cumin) on C57BL6/j Mice Fed High-Fat Diet. Journal of Visualized Experiments. 2021 Jul; (173). doi: 10.3791/62087
Saxena A, Mukhopadhyay AK, Nandi SP. Antibacterial activity of selected plants extract against pathogenic bacteria and detection of phytochemicals. Journal of Environmental Biology. 2020 Nov 1;41(6):1486-92. doi: 10.22438/jeb/41/6/MRN-1550
Nelson S. The antibacterial activity of essential oils from Tagetes erecta and Thuja occidentalis. Cantarus. 2019; 27:29-33.
Jannuzzi A. Eugenol aggravates UVA-induced cytotoxic and genotoxic response in HaCaT human keratinocytes. Journal of Research in Pharmacy. 2022; 26(2). doi: 10.29228/jrp.133
Ghadermazi R, Keramat J, Goli SA. Antioxidant activity of clove (Eugenia caryophyllata Thunb), oregano (Oringanum vulgare L) and sage (Salvia officinalis L) essential oils in various model systems. International Food Research Journal. 2017 Jul; 24(4):1628.
Batiha GE, Beshbishy AM, El-Mleeh A, Abdel-Daim MM, Devkota HP. Traditional uses, bioactive chemical constituents, and pharmacological and toxicological activities of Glycyrrhiza glabra L.(Fabaceae). Biomolecules. 2020 Mar; 10(3). doi: 10.3390/biom10030352
Nerdy N and Ritarwan K. Hepatoprotective activity and nephroprotective activity of peel extract from three varieties of the passion fruit (Passiflora sp.) in the albino rat. Open access Macedonian Journal of Medical Sciences. 2019 Feb 28;7(4):536. doi: 10.3889/oamjms.2019.153
Hassan HA, Geniady MM, Abdelwahab SF, Abd-Elghany MI, Sarhan HA, Abdelghany AA, et al. Topical Eugenol Successfully Treats Experimental Candida albicans-Induced Keratitis. Ophthalmic Research. 2018; 60(2):69-79. doi: 10.1159/000488907
Sedigh Bazkiagourab M, Sattari M, Imanpour Namin J. Anesthetic effects of valerian extract (Valeriana officinalis), lemongrass extract (Cymbopogon citratus) and clove powder (Eugenia caryophyllata) on Sterlet sturgeon (Acipenser ruthenus). Aquatics Physiology and Biotechnology. 2021 Sep 22;9(2):59-86. doi: 10.22124/japb.2021.6718.1141
Guldiken B, Catalkaya G, Ozkan G, Ceylan FD, Capanoglu E. Toxicological effects of commonly used herbs and spices. InToxicology. Academic Press. 2021 Jan: 201-13.
How to Cite
Copyright (c) 2022 Pakistan BioMedical Journal
This work is licensed under a Creative Commons Attribution 4.0 International License.
This is an open-access journal and all the published articles / items are distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. For comments firstname.lastname@example.org