Influence of Lithium On Micro-Hardness of Dental Tissues: Lithium On Micro-Hardness of Dental Tissues

Shakila Nazir; Arsalan Mirza

doi:10.54393/pbmj.v8i3.1165

Authors

Shakila Nazir Faculty of Dentistry, Baqai Medical University, Karachi, Pakistan
Arsalan Mirza Department of Oral Biology, Baqai Dental College, Karachi, Pakistan

DOI:

https://doi.org/10.54393/pbmj.v8i3.1165

Keywords:

Developing Defects, Female Rabbits, Lithium, Micro-Hardness

Abstract

Lithium in pregnancy is related to the risk of preterm birth. The study is related to the influence of Lithium in which female rabbits were involved as an experimental model, the drug was given during pregnancy which might instigate the defects of teeth in their developing offspring which were utilized as a sample to evaluate the micro-hardness of dental tissues i.e. enamel and dentine. Objective: To evaluate the influence of lithium on the micro-hardness of dental tissues. Methods: The subjects were divided into two sets i.e. investigational and regulator, containing seven subjects per cluster (n=7), the sum of 168 samples. Micro-hardness was estimated on two tissues of teeth. Vickers Hardness gradation was tested by taking three indentations on each sample for enamel and dentine, distinctly with 50 gm of weight for 15 sec. Results: The statistical analysis was done by applying Student’s t-tests using SPSS version 25. A noteworthy decline occurred in maxillary incisors, premolars, and molars, with p-values of 0.001, 0.012, and 0.003, separately. Comparatively, mandibular teeth, affected the incisors and molars, with p-values 0.003 and 0.011. Hardness affected the dentine of maxillary incisors, premolars, and molars, with p-values of 0.006, 0.005, and 0.004 individually. Micro-hardness in dentine was lowered in all the maxillary and mandibular teeth except mandibular molars. Conclusions: It was concluded that the tested values indicated the drug’s effect on maxillary and mandibular teeth by reduced standards. The clinicians should therefore be careful prescribing the medication, particularly during pregnancy, eluding the unfortunate consequence of neonate’s teeth.

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