Frequency of Renal Diseases in Diabetic Patients: Renal diseases in diabetic patients

Misbah  Arshad; Mamoona  Ashfaq; Zainab  Sharmeen; Zargham  Mazhar; Kashifa  Ehsan

doi:10.52229/pbmj.v2i1.29

Authors

Misbah Arshad 1University Institute of Diet and Nutritional Sciences, Faculty of Allied Health Sciences, The University of Lahore, Lahore, Pakistan
Mamoona Ashfaq University Institute of Diet and Nutritional Sciences, Faculty of Allied Health Sciences, The University of Lahore, Lahore, Pakistan
Zainab Sharmeen University Institute of Diet and Nutritional Sciences, Faculty of Allied Health Sciences, The University of Lahore, Lahore, Pakistan
Zargham Mazhar University Institute of Diet and Nutritional Sciences, Faculty of Allied Health Sciences, The University of Lahore, Lahore, Pakistan
Kashifa Ehsan Shukat Khanum Memorial Hospital, Lahore, Pakistan

DOI:

https://doi.org/10.52229/pbmj.v2i1.29

Abstract

Diabetic nephropathy, also known as diabetic kidney disease is the chronic loss of kidney function occurring in those with diabetes mellitus. Diabetic nephropathy is one of the leading causes of chronic kidney disease (CKD) and end-stage renal disease (ESRD) globally. Protein loss in the urine due to damage to the glomeruli may become massive, and cause a low serum albumin with resulting generalized body swelling (edema) and result in the nephrotic syndrome. Objective: The aim of this study was to determine the frequency of renal disease in diabetic patients and its complications in Pakistan. Methods: A cross sectional study was conducted at Renal and Diabetic Departments of the Sir Ganga Ram Hospital, Lahore, over a period of 3 months, after obtaining the ethical approval from the The University of Lahore. A total number of 100 Diabetic patients were selected through non probability convenient sampling technique. Patients of both sexes and all age groups were included. Results: In this study 60% were male and 40% were female. About 41% diabetic patients were 1-6 month of age, 42% were 1-5 years old and 1% of 18-23 years old who had renal diseases while 9% patients were without any renal disease. whereas the prevalence of diabetes is more in infants than others which is 35%. But there was not significant association between onset of renal diseases with the onset of diabetes mellitus with p-value 0.24.

Conclusions: Results of current study showed that diabetes mellitus effecting individuals of all ages equally but there was not significant association between diabetes and renal diseases.

References

Andersen AR, Christiansen JS, Andersen JK, Kreiner S, Deckert T. (1983). Diabetic nephropathy in type 1 (insulin-dependent) diabetes: an epidemiological study. Diabetologia, 25(6): 496-501.

Krolewski AS, Warram JH, Christlieb AR, Busick EJ, Kahn CR. (1985). The changing natural history of nephropathy in Type I diabetes. Am J Med.78(5): 785-794.

Bojestig M, Arnqvist H, Hermansson G, Karlberg B, Ludvigsson J. (1994). Declining incidence of nephropathy in insulin-dependent diabetes mellitus. New England Journal of Medicine, 330(1): 15-18.

Diabetes Control and Complications Trial Research Group. (1993). The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. New England Journal of Medicine, 329(14): 977-986.

Deckert T, Poulsen J. (1981). Diabetic nephropathy: fault or destiny? Diabetologia.21(3): 178±83.

Tarnow L, Fagerud J, Rossing P, Nielsen FS, Cambien F, Parving HH. (1998). Cardiovascular morbidity and early mortality clusters in parents of IDDM patientswith diabetic nephropathy. Diabetologia.41(Suppl 1): A291-A291. 175 FIFTH AVE, NEW YORK, NY 10010 USA: SPRINGER VERLAG.

Earle K, Walker J, Hill C, Viberti G. (1992). Familial clustering of cardiovascular disease in patients with insulin-dependent diabetes and nephropathy. N Engl J Med.326(10):673±7.

Seaquist E, Goetz F, Rich S, Barbosa J. (1989). Familial clustering of diabetic kidney disease. Evidence for genetic susceptibility to diabetic nephropathy. N Engl J Med.320(18):1161±4.

National Institutes of Health. (2005). National Institute of Diabetes and Digestive and Kidney Diseases. US Renal Data System, USRDS 2004 annual data report. Am J Kidney Dis.45(Suppl 1):8-280.

Gregg EW, Beckles GL, Williamson DF, Leveille SG, Langlois JA, Engelgau MM, Narayan KM. (2000). Diabetes and physical disability among older U.S. adults. Diabetes Care,23(9):1272-7.

International Diabetes Federation (IDF): Diabetes Atlas: http://www.diabetesatlas.org/.

World Health Organization (WHO): Diabetes Facts and Figures: http://www.who.int/diabetes/facts/en./.

Ramachandran A, Mary S, Yamuna A, Murugesan N, Snehalatha C. (2008). High prevalence of diabetes and cardiovascular risk factors associated with urbanization in India. Diabetes Care. 31(5): 893–8.

Wild S, Roglic G, Green A, Sicree R, King H. (2004). Global prevalence of diabetes: estimates for the year 2000 and projections for 2030. Diabetes Care.27(5): 1047-53.

Adler S. (2004) Diabetic nephropathy: linking histology, cell biology, and genetics. Kidney Int.66(5):2095–106.

Alberti G, Zimmet P, Shaw J, Bloomgarden Z, Kaufman F, Silink M. (2004). Type 2 diabetes in the young: The evolving epidemic: The International Diabetes Federation ConsensusWorkshop. Diabetes Care.27(7):1798-811.

Zimmet P, Alberti KG, Kaufman F, Tajima N, Silink M, Arslanian S, Wong G, Bennett P, Shaw J, Caprio S, IDF Consensus Group. (2007). The metabolic syndrome in children and adolescents–an IDF consensus report. Pediatric diabetes. 8(5):299-306.

Alwakeel JS, Sulimani R, Al-Asaad H, Al-Harbi A, Tarif N, Al-Suwaida A, Al-Mohaya S, Isnani AC, Alam A, Hammad D. (2008). Diabetes complications in 1,952 type 2 diabetes mellitus patients managed in a single institution in Saudi Arabia. Ann Saudi Med.28(4):260-6.

Al Wakeel JS, Alsuwaida A, Isnani AC, Alharbi A, Alam A. (2009). Concomitant macro- and microvascular complications in diabetic nephropathy

Boutayeb A, Boutayeb S, Boutayeb W. (2013). Multi-morbidity of non communicable diseases and equity in WHO Eastern Mediterranean countries. International journal for equity in health, 12(1): 1-13