Hematological, Biochemical and Etiological factors of Chronic Liver Disease in a tertiary care Hospital of Lahore

Sami Ullah  Mumtaz; Amna  Akbar; Humaira  Waseem; Tayyeba  Komal; Somia  Iqtadar; Sajid  Abaidullah

doi:10.52229/pbmj.v1i1.48

Authors

Sami Ullah Mumtaz North Medical Ward, King Edward Medical University/ Mayo Hospital, Lahore, Pakistan
Amna Akbar Center for research in Molecular Medicine, University of Lahore, Lahore, Pakistan
Humaira Waseem Research Unit, Faculty of Allied Health Sciences, University of Lahore, Pakistan
Tayyeba Komal Pathology Department, King Edward Medical University, Lahore, Pakistan
Somia Iqtadar North Medical Ward, King Edward Medical University/ Mayo Hospital, Lahore, Pakistan
Sajid Abaidullah North Medical Ward, King Edward Medical University/ Mayo Hospital, Lahore, Pakistan

DOI:

https://doi.org/10.52229/pbmj.v1i1.48

Abstract

Chronic Liver Disease (CLD) progresses from hepatocyte inflammation to fibrosis, regeneration, cirrhosis and in some cases to Hepatocellular Carcinoma (HCC). In general, the main etiologies of Liver Cirrhosis (LC) are viral infections (hepatitis C and B viruses), chronic alcohol abuse and Non-Alcoholic Fatty Liver Disease (NAFLD), including Non-Alcoholic SteatoHepatitis (NASH). Major complications of CLD are ascites, upper gastrointestinal bleeding, jaundice (acute or chronic) and hepatic encephalopathy. Objectives:This study assesses the etiological factors and complications of CLDin a tertiary care hospital of Lahore,Pakistan. Study Design: Cross-sectional. Methods: Study was carried out in indoor and Accident & Emergency Departments of Mayo Hospital Lahore. 100 clinically diagnosed CLD cases were chosen through “Convenient Sampling” technique during 3 months. Observations:Most common complications of CLD were upper GI variceal Bleeding (48%) & hepatic encephalopathy (34%) and acute or chronic hepatitis (AVH) (33%). Other less common complications observed were hepatorenal syndrome (10%), Spontaneous bacterial peritonitis (15%), Ascites (5%) and HCC (10%).Conclusions:Hepatitis C was found as main etiological factor of CLD. Bleeding andhepatic encephalopathy are the common complications.Awareness programmes regarding CLD and its complications are mandatory in our society to improve human health.

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