Relationship Between Microalbuminuria and Activity of The Disease in Patients Suffering from Ulcerative Colitis: Microalbuminuria and Activity of the Disease in Patients Suffering from UC

Murad  Ali; Maryam  Ashfaq; Tariq  Tahir Butt; Bushra  Gohar Shah; Hammad Ur Rehman  Bhatti

doi:10.54393/pbmj.v5i6.531

Authors

Murad Ali Bacha Khan Medical College, MTI Mardan Medical Complex Mardan KPK
Maryam Ashfaq Pakistan Institute of Medical Sciences, Islamabad
Tariq Tahir Butt Sialkot Medical College, Sialkot
Bushra Gohar Shah Sahara Medical College, Narowal
Hammad Ur Rehman Bhatti Islam Medical and Dental College Sialkot

DOI:

https://doi.org/10.54393/pbmj.v5i6.531

Keywords:

CRP, ESR, Microalbuminuria, IBD, UC, Calprotectin

Abstract

Ulcerative Colitis (UC) is a gastrointestinal issue, in which inflammation of the tract takes place. The disease level may be severe, moderate, or mild, so the detection method was selected according to the disease level. Finding the disease level and diagnostic method of UC is challenging. Objective: To find out a non-interfering way for the assessment of the activity of the disease, which is particularly important for the detection of UC. Therefore, the main goal of this study is to find a safe method for the determination of disease severity in the patients suffering from UC. Methods: For this study, 93 patients were selected suffering from UC (UC). For the assessment of all the specific parameters, C-Reactive Protein (CRP), Rate of erythrocytes sedimentation (ESR) and calprotectin in fecal, commonly used turbidimetric-immunoassay, Enzyme-linked immunosorbent assay (ELISA) and Westergren technique was used. A partial clinical score was used for the estimation of disease severity and the level of microalbuminuria was used determined by the immuno-turbidimetric way. Results: Among 93 patients suffering from UC, 37 patients were male and 56 patients were female. The average age of the patients was 40 plus. Microalbuminuria was present in more than 52 % of the patients. The presence of microalbuminuria depends upon the severity level of the disease, the most severe patients with Inflammatory bowel disease (IBD) have a large amount of microalbuminuria. The CRP, rate of sedimentation of erythrocytes, and other proteins level also vary with disease level. Conclusion: To measure the activity or severity level of the UC, microalbuminuria is considered a safe or non-interfering marker

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