Prevalence of Helicobacter pylori Infection in Patients with Type 2 Diabetes Mellitus in Hyderabad, Pakistan: Helicobacter pylori Infection in Type 2 Diabetic Patients

Waqar Ahmed; Beenish Khanzada; Ramsha Zaman; Sadia Ansari; Kainat Mustafa; Autif Hussain Mangi; Ali Asghar

doi:10.54393/pbmj.v7i08.1124

Authors

Waqar Ahmed Institute of Biochemistry, University of Sindh, Jamshoro, Pakistan
Beenish Khanzada Institute of Biochemistry, University of Sindh, Jamshoro, Pakistan
Ramsha Zaman Institute of Biochemistry, University of Sindh, Jamshoro, Pakistan
Sadia Ansari Institute of Biochemistry, University of Sindh, Jamshoro, Pakistan
Kainat Mustafa Institute of Biochemistry, University of Sindh, Jamshoro, Pakistan
Autif Hussain Mangi Institute of Biochemistry, University of Sindh, Jamshoro, Pakistan
Ali Asghar Institute of Biochemistry, University of Sindh, Jamshoro, Pakistan

DOI:

https://doi.org/10.54393/pbmj.v7i08.1124

Keywords:

Epigastric Burning, Betel Nut Chewing, Glycated Hemoglobin, Body Mass Index, Diabetes Mellitus

Abstract

Type 2 diabetes mellitus occurs due to high blood glucose levels owing to insulin resistance or insufficiency. The uncontrolled glycemic levels could impact gastrointestinal inflammation indicating a potential link between T2DM and Helicobacter pylori infection. Objective: To study the risk factors and prevalence related to Helicobacter pylori in T2DM and non-diabetic mellitus patients in Hyderabad Pakistan. Methods: A case-control study with a cross-sectional design was done by including 146 participants from Hyderabad, divided into two groups, one with type 2 diabetes mellitus and the other healthy individuals. A 5 mL blood sample was taken to analyze HbA1C levels and Helicobacter pylori infection. A questionnaire was used to collect other demographic and clinical information. The significance of differences in the data were evaluated using t-test and chi-square. Results: Out of 146 participants, Helicobacter pylori was detected in 39.7% (29) of diabetic patients and 45.2% (33) of non-diabetic participants with no statistical significance (p-value > 0.05). Helicobacter pylori positive diabetic patients had higher BMI values and were found to be obese as compared to Non-DM Helicobacter pylori positive participants. In Helicobacter pylori positive non-diabetic patients, it was found statistically significant differences (p-value <0.05) among fast food consumption. Diabetic patients on prolonged use of medications were found to have significant incidence of Helicobacter pylori as compared to non-diabetics. Conclusion: This study revealed that Helicobacter pylori infection was significantly higher in non-diabetic control group than in diabetic patients.

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