Bacteriological Profile and Drug Resistance Pattern of Isolates of ICU Patients In Hospital Of Peshawar: Bacteriological Profile and Drug Resistance Pattern

Muhammad  Nabi; Shah  Zaman; Amna  Umar; Erum  Rehman; Zakia  Subhan; Nighat  Aziz; Nabiha  Naeem; Ambreen  Anjum; Irfan Ullah

doi:10.54393/pbmj.v5i6.603

Authors

Muhammad Nabi Institute of Pharmaceutical Sciences, Khyber Medical University,(IPS-KMU), Peshawar, Pakistan
Shah Zaman Department of Pharmacology, Peshawar Medical and Dental College, Peshawar, Pakistan
Amna Umar Department of Pharmacology, Peshawar Medical and Dental College, Peshawar, Pakistan
Erum Rehman Department of Pharmacology, Peshawar Medical and Dental College, Peshawar, Pakistan
Zakia Subhan Department of Pharmacology, Khyber Medical University Institute of Medical Sciences (KMU-IMS), Kohat, Pakistan
Nighat Aziz Department of Pharmacology, Gomal Medical College, Medical Teaching Institute, Dera Ismail Khan, Pakistan
Nabiha Naeem Department of Life Sciences, School of Science, University of Management and Technology (UMT), Lahore, Pakistan
Ambreen Anjum Department of Psychology, Virtual University of Pakistan
Irfan Ullah Department of Life Sciences, School of Science, University of Management and Technology (UMT), Lahore, Pakistan

DOI:

https://doi.org/10.54393/pbmj.v5i6.603

Keywords:

Multidrug-resistant, infectious diseases, morbidity, death, intensive care units

Abstract

Multidrug-resistant infectious diseases are one of the top causes of death and morbidity among hospitalized patients worldwide. Objective: This study’s aim was to assess the frequency of common bacterial pathogens, as well as their antibiotic sensitivity & resistance, in various Intensive care unit tertiary care hospitals. Methods: The current investigation was conducted from February to May 2021 in multiple ICU at a primary care hospital in Peshawar. Patients who were admitted to any of the hospital's four intensive care units (ICUs) and patients medically speculated of having an infection within 48 hours of arrival were included. Patients' laboratory samples were selected based on clinical suspicion. Antibiotic sensitivity testing was performed on the samples. Result: E. coli 33(26) was the most commonly isolated bacteria across all samples. “In NICU, CONS 17(67.78), in 7(28.28), in MICU, PICU E. coli, E. coli, Pseudomonas spp and Acinetobacter spp.11(22.39), and in E. coli, SICU 17(46.82) were predominantly isolated” “Amikacin 29(88.6), Cefuroxime 21(65), Klebsiella sp. to Cefoperazone+Salbactum 15(79), Pseudomonas to Tazobactum+Piperacillin 12(66), and Acinetobacter sp. to Sulbactum+Cefoperazone 12(66) are commonly used antibiotics against E. coli 12(56)”. Citrobacter spp. (67.8) was observed more followed by Proteus spp. (34.4) and Enterococcus (34.4). Conclusion: In the ICUs, infectious diseases and antimicrobial resistance are key barriers to patient outcome multidrug-resistant as well as expenditure. All intensive care units throughout the world face the issue of lowering the same.

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