Evaluation of Lipid Profile in H. Pylori Infected Coronary Artery Disease Patients: Evaluation of Lipid Profile in Coronary Artery Disease Patients

Mehk  Memon; Nosheen  Aghani; Waseem  Akram; Ghulam  Qadir; Mehwish  Memon; Mahrish  Memon

doi:10.54393/pbmj.v6i07.903

Authors

Mehk Memon Department of Biochemistry, Peoples University of Medical and Health Sciences for Women, Nawabshah, Pakistan
Nosheen Aghani Department of Biochemistry, Peoples University of Medical and Health Sciences for Women, Nawabshah, Pakistan
Waseem Akram Department of Pathology, Peoples University of Medical and Health Sciences for Women, Nawabshah, Pakistan
Ghulam Qadir Department of Surgery, Peoples University of Medical and Health Sciences for Women, Nawabshah, Pakistan
Mehwish Memon Bakhtawar Ameen Medical College, Multan, Pakistan
Mahrish Memon Institute of Physiotherapy and Rehabilitation Sciences, Peoples University of Medical and Health Sciences for Women, Nawabshah, Pakistan

DOI:

https://doi.org/10.54393/pbmj.v6i07.903

Keywords:

Triglycerides (TG), Low Density Lipoprotein (LDL), High Density Lipoprotein (HDL), Total Cholesterol (TG)

Abstract

Increase in low density lipoprotein level and decrease in high density lipoprotein level result to coronary artery disease. Metabolism of lipids regulated during host response to H. pylori infection. Objective: To analyze the serum levels of lipid profile in H. pylori infected coronary artery disease patients. Methods: It was a comparative Cross-Sectional study. This study was done at the Department of Biochemistry, Peoples University of Medical Health Sciences for Women (PUMHSW) from 1^st July 2022 to 15^th December 2022. A sample of 60 subjects was divided into 2 groups. Group A (Control) comprised of 30 subjects and group B (cases) of 30 subjects. 5 mL of blood from each participant was collected under aseptic conditions. For the Lipid profile, 2 mL of the blood was collected in the Gel test tubes. A Spectrophotometer was used to perform the lipid profile. For the data analyzes SPSS Version-22.0 was used. Results: In this study we found that Helicobacter pylori positive subjects have higher levels of serum LDL.C, Triglycerides and total cholesterol. The outcomes of present research showed that H. pylori is associated with low level of HDL-C. The present study results shown an association among H. pylori infection and coronary artery possibility influence. Conclusions: We concluded in this study that serum levels of lipid profile become worse in positive H. pylori infected patients as compared to the control group participants which were negative H. pylori with coronary artery disease.

References

Vafaeimanesh J, Hejazi SF, Damanpak V, Vahedian M, Sattari M, Seyyedmajidi M. Association of Helicobacter pylori infection with coronary artery disease: is Helicobacter pylori a risk factor? The Scientific World Journal. 2014 Jan; 2014: 516354. doi: 10.1155/2014/516354. DOI: https://doi.org/10.1155/2014/516354

Haeri M, Parham M, Habibi N, Vafaeimanesh J. Effect of Helicobacter pylori infection on serum lipid profile. Journal of Lipids. 2018 Jun; 2018: 6734809. doi: 10.1155/2018/6734809. DOI: https://doi.org/10.1155/2018/6734809

Al-Ghamdi A, Jiman-Fatani AA, El-Banna H. Role of Chlamydia pneumoniae, Helicobacter pylori and cytomegalovirus in coronary artery disease. Pakistan Journal of Pharmaceutical Sciences. 2011 Apr; 24(2): 95-101.

Temesgen GB, Menon M, Gizaw ST, Yimenu BW, Agidew MM. Evaluation of lipid profile and inflammatory marker in patients with gastric Helicobacter pylori infection, Ethiopia. International Journal of General Medicine. 2022 Jan; 15: 271-8. doi: 10.2147/IJGM.S345649. DOI: https://doi.org/10.2147/IJGM.S345649

Abdu A, Cheneke W, Adem M, Belete R, Getachew A. Dyslipidemia and associated factors among patients suspected to have Helicobacter pylori infection at Jimma University Medical Center, Jimma, Ethiopia. International Journal of General Medicine. 2020 Jun; 13: 311-21. doi: 10.2147/IJGM.S243848.

Nam SY, Ryu KH, Park BJ, Park S. Effects of Helicobacter pylori infection and its eradication on lipid profiles and cardiovascular diseases. Helicobacter. 2015 Apr; 20(2): 125-32. doi: 10.1111/hel.12182.

Jukic A, Bozic D, Kardum D, Becic T, Luksic B, Vrsalovic M, et al. Helicobacter pylori infection and severity of coronary atherosclerosis in patients with chronic coronary artery disease. Therapeutics and Clinical Risk Management. 2017 Jul; 13: 933-8. doi: 10.2147/TCRM.S142193. DOI: https://doi.org/10.2147/TCRM.S142193

Ndebi ME, Guimtsop YA, Tamokou JD. The assessment of risk factors, lipid profile, uric acid and alanine aminotransferase in Helicobacter pylori-positive subjects. International Journal of Research in Medical Sciences. 2018 Sep; 6(9): 2889. doi: 10.18203/2320-6012.ijrms20183623. DOI: https://doi.org/10.18203/2320-6012.ijrms20183623

Sharma V and Aggarwal A. Helicobacter pylori: Does it add to risk of coronary artery disease. World Journal of Cardiology. 2015 Jan; 7(1): 19. doi: 10.4330/wjc.v7.i1.19. DOI: https://doi.org/10.4330/wjc.v7.i1.19

Kucukazman M, Yavuz B, Sacikara M, Asilturk Z, Ata N, Ertugrul DT, et al. The relationship between updated Sydney System score and LDL cholesterol levels in patients infected with Helicobacter pylori. Digestive Diseases and Sciences. 2009 Mar; 54(3): 604-7. doi: 10.1007/s10620-008-0391-y. DOI: https://doi.org/10.1007/s10620-008-0391-y

Sung KC, Rhee EJ, Ryu SH, Beck SH. Prevalence of Helicobacter pylori infection and its association with cardiovascular risk factors in Korean adults. International Journal of Cardiology. 2005 Jul; 102(3): 411-7. doi: 10.1016/j.ijcard.2004.05.040. DOI: https://doi.org/10.1016/j.ijcard.2004.05.040

Hoffmeister A, Rothenbacher D, Bode G, Persson K, März W, Nauck MA, et al. Current infection with Helicobacter pylori, but not seropositivity to Chlamydia pneumoniae or cytomegalovirus, is associated with an atherogenic, modified lipid profile. Arteriosclerosis, Thrombosis, and Vascular Biology. 2001 Mar; 21(3): 427-32. doi: 10.1161/01.ATV.21.3.427. DOI: https://doi.org/10.1161/01.ATV.21.3.427

Takashima T, Adachi K, Kawamura A, Yuki M, Fujishiro H, Rumi MA, et al. Cardiovascular risk factors in subjects with Helicobacter pylori infection. Helicobacter. 2002 Apr; 7(2): 86-90. doi: 10.1046/j.1083-4389.2002.00064.x. DOI: https://doi.org/10.1046/j.1083-4389.2002.00064.x

Maleki VS, Zarkesh EH, Behjati M. Helicobacter pylori’s evasion of the immune system could establish an inflammatory environment that potentially induces the development of coronary artery disease. Jundishapur Journal of Microbiology. 2013Jan; 6(3): 242-7. doi:10.5812/jjm.5038. DOI: https://doi.org/10.5812/jjm.5038

Shimamoto T, Yamamichi N, Gondo K, Takahashi Y, Takeuchi C, Wada R, et al. The association of Helicobacter pylori infection with serum lipid profiles: An evaluation based on a combination of meta-analysis and a propensity score-based observational approach. PLoS One. 2020 Jun; 15(6): e0234433. doi: 10.1371/journal.pone.0234433. DOI: https://doi.org/10.1371/journal.pone.0234433

Guzman E, Montes P, Monge E. Relation between Patients with Gastric Helicobacter Pylori Infection and Dyslipidemia. Journal of Gastrointestinal Disorders and Liver Function. 2015 Oct, 1(1): 1-4. doi: 10.15436/2471-0601.15.004. DOI: https://doi.org/10.15436/2471-0601.15.004

Hissun Y, Modawe GA, Abdrabo AE. Association between H. pylori and coronary heart disease among Sudanese patients. International Journal of Informative Research and Review. 2016 Jan; 3: 1589-93.

Nam SY, Ryu KH, Park BJ, Park S. Effects of Helicobacter pylori infection and its eradication on lipid profiles and cardiovascular diseases. Helicobacter. 2015 Apr; 20(2): 125-32. doi: 10.1111/hel.12182. DOI: https://doi.org/10.1111/hel.12182

Abdu A, Cheneke W, Adem M, Belete R, Getachew A. Dyslipidemia and associated factors among patients suspected to have Helicobacter pylori infection at Jimma University Medical Center, Jimma, Ethiopia. International Journal of General Medicine. 2020 Jun; 13: 311-21. doi: 10.2147/IJGM.S243848. DOI: https://doi.org/10.2147/IJGM.S243848

Longo-Mbenza B, Nsenga JN, Ngoma DV. Prevention of the metabolic syndrome insulin resistance and the atherosclerotic diseases in Africans infected by Helicobacter pylori infection and treated by antibiotics. International Journal of Cardiology. 2007 Oct; 121(3): 229-38. doi: 10.1016/j.ijcard.2006.12.003. DOI: https://doi.org/10.1016/j.ijcard.2006.12.003