Pervasiveness and determinants assessment of chronic kidney disease in Pakistani population: A 2-years cross sectional study

Hafiz Muhammad Attaullah; Aqib  Razzaq; Sundus  Rashid; Sania  Hafeez; Qurat ul Ain; Umama  Hassan; Seemab  Rafiq; Jafir Hussain  Shirazi; Qazi  Adnan

doi:10.54393/pbmj.v5i1.208

Authors

Hafiz Muhammad Attaullah The Islamia University of Bahawalpur
Aqib Razzaq Department of Pharmaceutics, Faculty of Pharmacy, The Islamia University of Bahawalpur, Pakistan
Sundus Rashid Islamic International Medical College, Riphah University, Islamabad, Pakistan
Sania Hafeez Department of Pharmaceutics, Faculty of Pharmacy, The Islamia University of Bahawalpur, Pakistan
Qurat ul Ain Department of Pharmaceutics, Faculty of Pharmacy, The Islamia University of Bahawalpur, Pakistan
Umama Hassan Department of Pharmaceutics, Faculty of Pharmacy, The Islamia University of Bahawalpur, Pakistan
Seemab Rafiq Department of Pharmaceutics, Faculty of Pharmacy, The Islamia University of Bahawalpur, Pakistan
Jafir Hussain Shirazi Department of Pharmaceutics, Faculty of Pharmacy, The Islamia University of Bahawalpur, Pakistan
Qazi Adnan Department of Pharmaceutics, Faculty of Pharmacy, The Islamia University of Bahawalpur, Pakistan

DOI:

https://doi.org/10.54393/pbmj.v5i1.208

Keywords:

Keywords CKD, eGFR, Kidney disease, Kidney failure.

Abstract

Chronic Kidney Disease (CKD) prevalence studies has been carried out in various parts of the world including Pakistan. Unluckily, the majority of these studies focused on the urban settings, neglecting the rural areas. current study has found very serious outcomes about CKD prevalence in remote areas. CKD was found gender specificity as well as geo-specificity in prevalence of CKD. PURPOSE: Aim of this study was to assess CKD prevalence in the least accessed and underdeveloped areas of Pakistan. METHODS: The area of study was Bahawalpur Victoria Hospital (BVH). Bahawalpur. The study was carried out between January 1, 2018- December 31, 2019. STATISTICS: All statistical parameters were calculated with the help of MS Office 360, GraphPad Prism 8, and SPSS 16. RESULTS: The most vulnerable locales were hinterland and underdeveloped regions. When we demarcate our studies putting focus on the gender, we found that male gender was more susceptible to the disease than the female one. Quinquagenarians were found to be among those most affected. Whereas octogenarians were among those with the least affected ratio. CONCLUSIONS: We reach the conclusion that since rural areas being the ones most affected, there is dire need to enhance the gambit of research to a higher level.

References

Appel, Lawrence J, Jackson T Wright, Tom Greene, John W Kusek, Julia B Lewis, Xuelei Wang, Michael S Lipkowitz, et al. "Long-Term Effects of Renin-Angiotensin System-Blocking Therapy and a Low Blood Pressure Goal on Progression of Hypertensive Chronic Kidney Disease in African Americans." Archives of Internal Medicine 168, no. 8 (2008): 832-39.

https://doi.org/10.1001/archinte.168.8.832

Control, Centers for Disease, and Prevention. "Prevalence of Chronic Kidney Disease and Associated Risk Factors--United States, 1999-2004." MMWR. Morbidity and mortality weekly report 56, no. 8 (2007): 161.

Hossain, Mohammed P, Elizabeth C Goyder, Jan E Rigby, and Meguid El Nahas. "Ckd and Poverty: A Growing Global Challenge." American Journal of Kidney Diseases 53, no. 1 (2009): 166-74.

https://doi.org/10.1053/j.ajkd.2007.10.047

Islam, Tareq M., Caroline S. Fox, Devin Mann, and Paul Muntner. "Age-Related Associations of Hypertension and Diabetes Mellitus with Chronic Kidney Disease." BMC Nephrology 10, no. 1 (2009/06/30 2009): 17. https://doi.org/10.1186/1471-2369-10-17. https://doi.org/10.1186/1471-2369-10-17.

https://doi.org/10.1186/1471-2369-10-17

Jafar, Tazeen H, Andrew S Levey, Fahim H Jafary, Franklin White, Asma Gul, Mohammad H Rahbar, Abdul Q Khan, et al. "Ethnic Subgroup Differences in Hypertension in Pakistan." Journal of hypertension 21, no. 5 (2003): 905-12.

https://doi.org/10.1097/00004872-200305000-00014

Jessani, Saleem, Rasool Bux, and Tazeen H Jafar. "Prevalence, Determinants, and Management of Chronic Kidney Disease in Karachi, Pakistan-a Community Based Cross-Sectional Study." BMC nephrology 15, no. 1 (2014): 90.

https://doi.org/10.1186/1471-2369-15-90

Kim, Suhnggwon, Chun Soo Lim, Dong Cheol Han, Gyo Sun Kim, Ho Jun Chin, Seung-Jung Kim, Won Yong Cho, Yeong Hoon Kim, and Yon-Su Kim. "The Prevalence of Chronic Kidney Disease (Ckd) and the Associated Factors to Ckd in Urban Korea: A Population-Based Cross-Sectional Epidemiologic Study." Journal of Korean medical science 24, no. Suppl 1 (2009): S11.

https://doi.org/10.3346/jkms.2009.24.S1.S11

Kuo, Hsin-Wei, Shang-Shyue Tsai, Mao-Meng Tiao, and Chun-Yuh Yang. "Epidemiological Features of Ckd in Taiwan." American journal of kidney diseases 49, no. 1 (2007): 46-55.

https://doi.org/10.1053/j.ajkd.2006.10.007

Levey, Andrew S, and Josef Coresh. "Chronic Kidney Disease." The lancet 379, no. 9811 (2012): 165-80.

https://doi.org/10.1016/S0140-6736(11)60178-5

Levey, Andrew S, Kai-Uwe Eckardt, Yusuke Tsukamoto, Adeera Levin, Josef Coresh, Jerome Rossert, Dick DE Zeeuw, et al. "Definition and Classification of Chronic Kidney Disease: A Position Statement from Kidney Disease: Improving Global Outcomes (Kdigo)." Kidney international 67, no. 6 (2005): 2089-100.

https://doi.org/10.1111/j.1523-1755.2005.00365.x

Levey, Andrew S., Sharon P. Andreoli, Thomas DuBose, Robert Provenzano, and Allan J. Collins. "Chronic Kidney Disease: Common, Harmful and Treatable-World Kidney Day 2007." American journal of nephrology 27, no. 1 (2007): 108-12.

https://doi.org/10.1159/000099801

Neugarten, Joel, and Ladan Golestaneh. "Gender and the Prevalence and Progression of Renal Disease." Advances in chronic kidney disease 20, no. 5 (2013): 390-95.

https://doi.org/10.1053/j.ackd.2013.05.004

O'Hare, Ann M., Daniel Bertenthal, Kenneth E. Covinsky, C. Seth Landefeld, Saunak Sen, Kala Mehta, Michael A. Steinman, Ann Borzecki, and Louise C. Walter. "Mortality Risk Stratification in Chronic Kidney Disease: One Size for All Ages?". Journal of the American Society of Nephrology 17, no. 3 (2006): 846-53.

https://doi.org/10.1681/ASN.2005090986

Oh, Kook-Hwan, Sue Kyung Park, Hayne Cho Park, Ho Jun Chin, Dong Wan Chae, Kyu Hun Choi, Seung Hyeok Han, et al. "Know-Ckd (Korean Cohort Study for Outcome in Patients with Chronic Kidney Disease): Design and Methods." BMC nephrology 15, no. 1 (2014): 80.

https://doi.org/10.1186/1471-2369-15-80

Peterson, John C, Sharon Adler, John M Burkart, Tom Greene, Lee A Hebert, Lawrence G Hunsicker, Andrew J King, et al. "Blood Pressure Control, Proteinuria, and the Progression of Renal Disease: The Modification of Diet in Renal Disease Study." Annals of internal medicine 123, no. 10 (1995): 754-62.

https://doi.org/10.7326/0003-4819-123-10-199511150-00003

Rahman, Mahboob, and Michael C Smith. "Chronic Renal Insufficiency: A Diagnostic and Therapeutic Approach." Archives of internal Medicine 158, no. 16 (1998): 1743-52.

https://doi.org/10.1001/archinte.158.16.1743

Redmon, Jennifer Hoponick, Myles F Elledge, Donna S Womack, Rajitha Wickremashinghe, Kamani P Wanigasuriya, Roshini J Peiris-John, Joseph Lunyera, et al. "Additional Perspectives on Chronic Kidney Disease of Unknown Aetiology (Ckdu) in Sri Lanka-Lessons Learned from the Who Ckdu Population Prevalence Study." BMC nephrology 15, no. 1 (2014): 1-10.

https://doi.org/10.1186/1471-2369-15-125

Ritz, Eberhard, and Vedat Schwenger. "Lifestyle Modification and Progressive Renal Failure." Nephrology 10, no. 4 (2005): 387-92.

https://doi.org/10.1111/j.1440-1797.2005.00439.x

Shera, AS, F Jawad, and A Maqsood. "Prevalence of Diabetes in Pakistan." Diabetes research and clinical practice 76, no. 2 (2007): 219-22.

https://doi.org/10.1016/j.diabres.2006.08.011

Tiao, Jim Yu-Hsiang, James B. Semmens, John R. L. Masarei, and Michael M. D. Lawrence-Brown. "The Effect of Age on Serum Creatinine Levels in an Aging Population: Relevance to Vascular Surgery." Cardiovascular surgery 10, no. 5 (2002): 445-51.

https://doi.org/10.1016/S0967-2109(02)00056-X

van den Brand, Jan AJG, Gerben AJ van Boekel, Hans L Willems, Lambertus ALM Kiemeney, Martin den Heijer, and Jack FM Wetzels. "Introduction of the Ckd-Epi Equation to Estimate Glomerular Filtration Rate in a Caucasian Population." Nephrology Dialysis Transplantation 26, no. 10 (2011): 3176-81.

https://doi.org/10.1093/ndt/gfr003