A Prospective Cohort Study on Suspected COVID-19 Patients undergoing Nasopharyngeal Swab PCR and HRCT

Nasopharyngeal Swab PCR and HRCT in COVID-19 Patients

Authors

  • Akash John University Institute of Radiological and Medical Imaging Sciences, The University of Lahore, Gujrat Campus
  • Tallat Anwar Faridi University Institute of Public Health, The University of Lahore
  • Kubra Samreen Medical Imaging Technologist, Sharif Medical City Hospital, Lahore
  • Anil Gill Gujranwala Institute of Medical and Emerging Sciences, Gujranwala
  • Sofia Noor Operation Theatre Technologist, District Head Quarter (DHQ Hospital), Okara
  • Neelam Iqbal Institute of Molecular Biology and Biotechnology, The University of Lahore
  • Nayab John University Institute of Physical therapy, University of Lahore, Gujrat campus

DOI:

https://doi.org/10.54393/pbmj.v4i1.82

Abstract

Objective:To Determine the Specificity, Accuracy and Sensitivity of HRCT in Diagnosis of Covi-19.

Methods: Prospective cohort study was done with 181 participants who were suspected for COVID-19 infection and were followed to evaluate PCR and HRCT reporting in patients with clinical symptoms.

Results: 86.8% of patients had a dry cough, followed most commonly with shortness of breath. 65 (35.9%) of patients had ground-glass opacities of haze on HRCT followed by 47 (26 %). who had consolidations present. 147 (81.2)patients had a positive PCR whereas 34 (18.7%) was negative had an HRCT that was suggestive of having COVID-19 pneumonia.

Conclusion:In conclusion clinical symptomatology, HRCT findings and PCR all should be used in a triple examination. It is concluded that a positive PCR test is very specific and used to make diagnosis for Covid-19. CT has a higher sensitivity but a lower specificity, thus helping with disease diagnosis and therapy.

References

Fanelli D, Piazza F. Analysis and forecast of COVID-19 spreading in China, Italy and France. Chaos, Solitons & Fractals. 2020;134:109761.

Mo P, Xing Y, Xiao Y, Deng L, Zhao Q, Wang H, et al. Clinical characteristics of refractory COVID-19 pneumonia in Wuhan, China. Clin Infect Dis. 2020.

Pascarella G, Strumia A, Piliego C, Bruno F, Del Buono R, Costa F, et al. COVID‐19 diagnosis and management: a comprehensive review. Journal of internal medicine. 2020;288(2):192-206.

Abbasi-Oshaghi E, Mirzaei F, Farahani F, Khodadadi I, Tayebinia H. Diagnosis and treatment of coronavirus disease 2019 (COVID-19): Laboratory, PCR, and chest CT imaging findings. International Journal of Surgery. 2020;79:143-53.

Bénézit F, Le Turnier P, Declerck C, Paillé C, Revest M, Dubée V, et al. Utility of hyposmia and hypogeusia for the diagnosis of COVID-19. The Lancet Infectious Diseases. 2020;20(9):1014-5.

Long C, Xu H, Shen Q, Zhang X, Fan B, Wang C, et al. Diagnosis of the Coronavirus disease (COVID-19): rRT-PCR or CT? European journal of radiology. 2020;126:108961.

Majidi H, Niksolat F. Chest CT in patients suspected of COVID-19 infection: A reliable alternative for RT-PCR. The American journal of emergency medicine. 2020;38(12):2730-2.

Zhai P, Ding Y, Wu X, Long J, Zhong Y, Li Y. The epidemiology, diagnosis and treatment of COVID-19. International journal of antimicrobial agents. 2020;55(5):105955.

Kovács A, Palásti P, Veréb D, Bozsik B, Palkó A, Kincses ZT. The sensitivity and specificity of chest CT in the diagnosis of COVID-19. European Radiology. 2021;31(5):2819-24.

Waris A, Atta U, Ali M, Asmat A, Baset A. COVID-19 outbreak: current scenario of Pakistan. New Microbes and New Infections. 2020;35:100681.

Caruso D, Zerunian M, Polici M, Pucciarelli F, Polidori T, Rucci C, et al. Chest CT features of COVID-19 in Rome, Italy. Radiology. 2020;296(2):E79-E85.

Xie X, Zhong Z, Zhao W, Zheng C, Wang F, Liu J. Chest CT for typical coronavirus disease 2019 (COVID-19) pneumonia: relationship to negative RT-PCR testing. Radiology. 2020;296(2):E41-E5.

Fang Y, Zhang H, Xie J, Lin M, Ying L, Pang P, et al. Sensitivity of chest CT for COVID-19: comparison to RT-PCR. Radiology. 2020;296(2):E115-E7.

Wong HYF, Lam HYS, Fong AH-T, Leung ST, Chin TW-Y, Lo CSY, et al. Frequency and distribution of chest radiographic findings in patients positive for COVID-19. Radiology. 2020;296(2):E72-E8.

Wang Y, Hou H, Wang W, Wang W. Combination of CT and RT-PCR in the screening or diagnosis of COVID-19. Journal of global health. 2020;10(1).

Ng M-Y, Lee EY, Yang J, Yang F, Li X, Wang H, et al. Imaging profile of the COVID-19 infection: radiologic findings and literature review. Radiology: Cardiothoracic Imaging. 2020;2(1):e200034.

He J-L, Luo L, Luo Z-D, Lyu J-X, Ng M-Y, Shen X-P, et al. Diagnostic performance between CT and initial real-time RT-PCR for clinically suspected 2019 coronavirus disease (COVID-19) patients outside Wuhan, China. Respiratory medicine. 2020;168:105980.

Khatami F, Saatchi M, Zadeh SST, Aghamir ZS, Shabestari AN, Reis LO, et al. A meta-analysis of accuracy and sensitivity of chest CT and RT-PCR in COVID-19 diagnosis. Scientific reports. 2020;10(1):1-12.

Lan L, Xu D, Ye G, Xia C, Wang S, Li Y, et al. Positive RT-PCR test results in patients recovered from COVID-19. Jama. 2020;323(15):1502-3.

Oudkerk M, Büller HR, Kuijpers D, van Es N, Oudkerk SF, McLoud T, et al. Diagnosis, prevention, and treatment of thromboembolic complications in COVID-19: report of the National Institute for Public Health of the Netherlands. Radiology. 2020;297(1):E216-E22.

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Published

2021-06-25
CITATION
DOI: 10.54393/pbmj.v4i1.82
Published: 2021-06-25

How to Cite

John, A. ., Faridi, T. A. ., Samreen, K. ., Gill, A., Noor, S. ., Iqbal, N. ., & John, N. . (2021). A Prospective Cohort Study on Suspected COVID-19 Patients undergoing Nasopharyngeal Swab PCR and HRCT: Nasopharyngeal Swab PCR and HRCT in COVID-19 Patients. Pakistan BioMedical Journal, 4(1). https://doi.org/10.54393/pbmj.v4i1.82

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