Immuno-histochemical Expression of Cyclin D1 in Oral Squamous Cell Carcinoma, Oral Potentially Malignant Disorders, and Normal Oral Mucosa: Cyclin D1 in Oral Squamous Cell Carcinoma

Shabana  Bakhtiar; Sabeen  Nasir; Sara  Zia; Hoor  Maryam; Natasha  Kamran; Karishma  Ali

doi:10.54393/pbmj.v5i7.674

Authors

Shabana Bakhtiar Department of Oral Pathology, Peshawar Medical and Dental College, Peshawar (Affiliated with Riphah International University, Islamabad
Sabeen Nasir Department of Histopathology, Peshawar Medical College, Peshawar (Affiliated with Riphah International University, Islamabad)
Sara Zia Department of Histopathology, Peshawar Medical College, Peshawar (Affiliated with Riphah International University, Islamabad)
Hoor Maryam Department of Oral Pathology, Peshawar Medical and Dental College, Peshawar (Affiliated with Riphah International University, Islamabad)
Natasha Kamran Department of Oral Pathology, Peshawar Medical and Dental College, Peshawar (Affiliated with Riphah International University, Islamabad)
Karishma Ali Department of Oral Pathology, Peshawar Medical and Dental College, Peshawar (Affiliated with Riphah International University, Islamabad)

DOI:

https://doi.org/10.54393/pbmj.v5i7.674

Keywords:

Oral Potentially Malignant Disorders, Oral Squamous Cell Carcinoma, Cyclin D1 Immuno-histochemisrty

Abstract

Due to a high risk and tendency of OPMDs towards OSCC, its early detection is essential for better survival rate. Several molecular markers are available for diagnosis and prognostic assessments of OPMDs, also evaluating aggressiveness of OSCC. Objectives: To assess the immuno-histochemical expression of Cyclin D1 in OSCC, OPMDs, and normal healthy oral mucosa. Cyclin D1 has a significant role in cell cycle control and also strongly linked with the metastatic and poorly differentiated tumour cells. Methods: The study comprised of already diagnosed 20 cases of OSCC, 20 cases of OPMDs, and 20 normal oral mucosa cells, as a control. Results: Cyclin D1 immuno-reactivity was found positive in 100% cases of OPMDs, and 100% in OSCC but not in normal oral mucosa cells. Conclusion: A statistically significant expression of Cyclin D1 was observed in OPMDs which may indicate the probability of their transformation to OSCC.

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