Comparative Efficacy of Magnesium and Potassium Towards CKMB and Quality of Life in Type 2 Diabetes Mellitus Patients: Magnesium and Potassium Towards CKMB and Quality of Life in T2DM Patients

Mudassir Aziz; Uzma Rafi; Sidra Khalid; Sajid Hameed; Neelam Iqbal; Rana Hammad Ullah; Aiman Zulfiqar

doi:10.54393/pbmj.v7i08.1300

Authors

Mudassir Aziz Department of Biology, Lahore Garrison University, Lahore, Pakistan
Uzma Rafi Department of Biology, Lahore Garrison University, Lahore, Pakistan
Sidra Khalid Institute of Diet and Nutritional Sciences, The University of Lahore, Lahore, Pakistan
Sajid Hameed Department of Public Health, Green International University, Lahore, Pakistan
Neelam Iqbal Institute of Molecular Biology and Biotechnology, The University of Lahore, Lahore, Pakistan
Rana Hammad Ullah Pak Red Crescent Medical and Dental College, Lahore, Pakistan
Aiman Zulfiqar New York University, New York, United States of America

DOI:

https://doi.org/10.54393/pbmj.v7i08.1300

Keywords:

Cardiovascular Diseases, Creatine Kinase Myocardial Band, Potassium, Magnesium, Diabetes

Abstract

Cardiovascular diseases like myocardial infarction and acute coronary syndrome are common complications in diabetes that can be diagnosed by performing various lab tests, like the Creatine Kinase Myocardial Band (CKMB) test, which is used to evaluate the cardiovascular risks in patients. Objectives: To compare the effects of magnesium and potassium supplementation on CKMB levels and quality of life in type 2 diabetes mellitus patients, focusing on their role in electrolyte balance and cardiovascular risk reduction. Methods: A randomized controlled trial (single-blind) was conducted at Lahore Garrison University, Lahore. Additionally, parameters related to diabetes management, such as blood glucose levels, HbA1c levels, magnesium, and potassium, were also evaluated. The study comprised 80 patients asked to check the effect of magnesium and potassium before and after a two-month dose of two months. Four groups were formed named T1, T2, T3, and T4, which were given a placebo, magnesium, potassium, and a combination of magnesium-potassium, respectively. Results: The Mean age of the participants was 49.675 ± 10.8660. Out of 80 participants, 28 (35%) were female and 52 (65%) were male. Potassium supplements significantly lowered the CKMB value in Type 2 Diabetes Mellitus (T2DM) patients, with the largest decrease in the T3 group. Quality of life was also improved significantly after using supplementation. Conclusions: The treatment positively affected the level of CKMB in the T3 group, which was provided with potassium supplements, suggesting that potassium is effective for lowering the CKMB values. This means that this supplement minimizes the risk of cardiac problems in T2DM.

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